{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:03:29Z","timestamp":1791576209359,"version":"4.3.4"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5]]},"abstract":"\n Study Design:<\/jats:title>\n Comparative evaluation of in vitro and in vivo biomechanics, resulting fusion and histomorphometric aspects of polyetheretherketone (PEEK) versus titanium (Ti) interbody fusion devices in an animal model with similar volumes of bone graft.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n Identify differences in the characteristics of fusion and biomechanics immediately following implantation (time 0) and at 26 weeks with each interbody implant.<\/jats:p>\n <\/jats:sec>\n \n Summary of Background Data:<\/jats:title>\n PEEK has been well accepted in spinal surgery, it provides a closer match to the mechanical properties of bone than metallic implants such as Ti. This is thought to reduce graft stress shielding and subsidence of interbody fusion devices. There remains controversy as to the overall influence of this as a factor influencing resultant fusion and initial stability. Although material modulus is 1 factor of importance, other design factors are likely to play a large role determining overall performance of an interbody implant.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A Ti and PEEK device of similar size with a central void to accommodate graft material were compared. The PEEK device had a ridged surface on the caudal and cephalad surfaces, whereas Ti device allowed axial compliance and had bone ingrowth endplates and polished internal surfaces. A 2-level ALIF was performed in 9 sheep and fusion, biomechanics, and bone apposition were evaluated at 26 weeks. Time 0 in vitro biomechanical tests were performed to establish initial stability immediately after implantation.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n No differences were detected in the biomechanical measures of each of the devices in in vitro time 0 tests. All levels were fused by 26 weeks with considerably lower range of motion when compared with in vitro tests. Range of motion in all modes of bending was reduced by over 70% when compared with intact values for axial rotation (Ti-74%, PEEK-71%), lateral bending (Ti-90%, PEEK-88%), and flexion\/extension (Ti-92%, PEEK-91%). Mechanical properties of fusions formed with each implant did not differ; however, bone apposition was variable with polished internal Ti surfaces being lower than PEEK and treated Ti endplates showing the greatest levels. Graft material displayed axial trabecular alignment with both implants.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Although material properties and surface characteristics resulted in differing amounts of biological integration from the host, both implants were capable of producing excellent fusion results using similar volumes of bone graft.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/bsd.0b013e31826851a4","type":"journal-article","created":{"date-parts":[[2012,7,17]],"date-time":"2012-07-17T13:30:04Z","timestamp":1342531804000},"page":"E208-E214","source":"Crossref","is-referenced-by-count":60,"title":["PEEK Versus Ti Interbody Fusion Devices"],"prefix":"10.1097","volume":"29","author":[{"given":"Matthew Henry","family":"Pelletier","sequence":"first","affiliation":[{"name":"Surgical & Orthopaedic Research Laboratories Level 1, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Cordaro","sequence":"additional","affiliation":[{"name":"SeaSpine Inc., Vista, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhav M.","family":"Punjabi","sequence":"additional","affiliation":[{"name":"Surgical & Orthopaedic Research Laboratories Level 1, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Waites","sequence":"additional","affiliation":[{"name":"Surgical & Orthopaedic Research Laboratories Level 1, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abe","family":"Lau","sequence":"additional","affiliation":[{"name":"Surgical & Orthopaedic Research Laboratories Level 1, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Surgical & Orthopaedic Research Laboratories Level 1, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230831","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1016\/j.biomaterials.2007.07.013","article-title":"PEEK biomaterials in trauma, orthopedic, and spinal implants","volume":"28","author":"Kurtz","year":"2007","journal-title":"Biomaterials"},{"key":"R2-20230831","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.biomaterials.2005.07.011","article-title":"Polyetheretherketone as a biomaterial for spinal applications","volume":"27","author":"Toth","year":"2006","journal-title":"Biomaterials"},{"key":"R3-20230831","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/jor.1100140513","article-title":"Altered load history affects periprosthetic bone loss following cementless total hip arthroplasty","volume":"14","author":"Bryan","year":"1996","journal-title":"J Orthop Res"},{"key":"R4-20230831","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/BSD.0b013e3181af3a84","article-title":"Outcomes of interbody fusion cages used in 1 and 2-levels anterior cervical discectomy and fusion: titanium cages versus polyetheretherketone (PEEK) cages","volume":"23","author":"Niu","year":"2010","journal-title":"J Spinal Disord Tech"},{"key":"R5-20230831","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.spinee.2005.08.020","article-title":"The multidirectional bending properties of the human lumbar intervertebral disc","volume":"6","author":"Spenciner","year":"2006","journal-title":"Spine J"},{"key":"R6-20230831","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1007\/s00586-005-0961-z","article-title":"The in vitro stabilising effect of polyetheretherketone cages versus a titanium cage of similar design for anterior lumbar interbody fusion","volume":"14","author":"Spruit","year":"2005","journal-title":"Eur Spine J"},{"key":"R7-20230831","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s007010100017","article-title":"Resistance of the lumbar spine against axial compression forces after implantation of three different posterior lumbar interbody cages","volume":"143","author":"Krammer","year":"2001","journal-title":"Acta Neurochir (Wien)"},{"key":"R8-20230831","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s00104-002-0489-2","article-title":"Experimental fusion of the sheep cervical spine. 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