{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:48:23Z","timestamp":1769168903548,"version":"3.49.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1097\/bsd.0b013e318287f2e2","type":"journal-article","created":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T10:10:43Z","timestamp":1361355043000},"page":"E277-E283","source":"Crossref","is-referenced-by-count":16,"title":["Adverse Events With the Use of rhBMP-2 in Thoracolumbar and Lumbar Spine Fusions"],"prefix":"10.1097","volume":"28","author":[{"given":"Daniel","family":"Lubelski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalil G.","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Steinmetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew D.","family":"Alvin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy S.","family":"Nowacki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srita","family":"Chakka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward C.","family":"Benzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Mroz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-12-20210204","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/00007632-200002010-00020","article-title":". The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans: a preliminary report.","volume":"25","author":"Boden","year":"2000","journal-title":"Spine"},{"key":"R2-12-20210204","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/00024720-200210000-00001","article-title":". Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages.","volume":"15","author":"Burkus","year":"2002","journal-title":"J Spinal Disord Tech"},{"key":"R3-12-20210204","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1097\/00007632-200112150-00026","article-title":"Laparoscopic anterior lumbar interbody fusion with rhBMP-2: a prospective study of clinical and radiographic outcomes.","volume":"26","author":"Kleeman","year":"2001","journal-title":"Spine"},{"key":"R6-12-20210204","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.spinee.2011.06.001","article-title":". A challenge to integrity in spine publications: years of living dangerously with the promotion of bone growth factors.","volume":"11","author":"Carragee","year":"2011","journal-title":"Spine J"},{"key":"R7-12-20210204","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.spinee.2011.04.023","article-title":"A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned.","volume":"11","author":"Carragee","year":"2011","journal-title":"Spine J"},{"key":"R8-12-20210204","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.spinee.2011.05.002","article-title":"Bone morphogenetic protein-2 and spinal arthrodesis: the basic science perspective on protein interaction with the nervous system.","volume":"11","author":"Dmitriev","year":"2011","journal-title":"Spine J"},{"key":"R9-12-20210204","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.spinee.2011.01.017","article-title":". Adjacent vertebral body osteolysis with bone morphogenetic protein use in transforaminal lumbar interbody fusion.","volume":"11","author":"Helgeson","year":"2011","journal-title":"Spine J"},{"key":"R10-12-20210204","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.spinee.2010.09.001","article-title":"Posterior iliac crest pain after posterolateral fusion with or without iliac crest graft harvest.","volume":"11","author":"Howard","year":"2011","journal-title":"Spine J"},{"key":"R11-12-20210204","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":". Research electronic data capture (REDCap)A metadata-driven methodology and workflow process for providing translational research informatics support.","volume":"42","author":"Harris","year":"2009","journal-title":"Journal of Biomedical Informatics"},{"key":"R13-12-20210204","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/BSD.0b013e31815ea897","article-title":". Complications in the use of rhBMP-2 in PEEK cages for interbody spinal fusions.","volume":"21","author":"Vaidya","year":"2008","journal-title":"J Spinal Disord Tech"},{"key":"R14-12-20210204","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1097\/BRS.0b013e31814b1bd8","article-title":". Posterior lumbar interbody fusion versus posterolateral fusion in adult isthmic spondylolisthesis.","volume":"32","author":"Ekman","year":"2007","journal-title":"Spine"},{"key":"R15-12-20210204","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/BSD.0b013e31802c1462","article-title":". Bone dowels in anterior lumbar interbody fusion.","volume":"20","author":"Lekovic","year":"2007","journal-title":"J Spinal Disord Tech"},{"key":"R16-12-20210204","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/00002517-200112000-00013","article-title":". Anteriorposterior lumbar fusion versus transforaminal lumbar interbody fusion: analysis of complications and predictive factors.","volume":"14","author":"Hee","year":"2001","journal-title":"J Spinal Disord"},{"key":"R17-12-20210204","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.spinee.2009.04.004","article-title":". Complications associated with single-level transforaminal lumbar interbody fusion.","volume":"9","author":"Rihn","year":"2009","journal-title":"Spine J"},{"key":"R18-12-20210204","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1097\/BRS.0b013e3181a396a1","article-title":"Recombinant human bone morphogenetic protein-2-induced radiculitis in elective minimally invasive transforaminal lumbar interbody fusions: a series review.","volume":"34","author":"Mindea","year":"2009","journal-title":"Spine"},{"key":"R19-12-20210204","first-page":"488","article-title":". L5-S1 laparoscopic anterior interbody fusion.","volume":"10","author":"Frantzides","year":"2006","journal-title":"JSLS"},{"key":"R20-12-20210204","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.neuchi.2008.09.003","article-title":". Anterior lumbar interbody fusion for treatment of failed back surgery syndrome: a retrospective study of 46 cases.","volume":"55","author":"Simon","year":"2009","journal-title":"Neurochirurgie"},{"key":"R22-12-20210204","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.jocn.2010.10.012","article-title":". Outcome of posterior lumbar interbody fusion versus posterolateral fusion in lumbar degenerative disease.","volume":"18","author":"Wu","year":"2011","journal-title":"J Clin Neurosci"},{"key":"R23-12-20210204","doi-asserted-by":"crossref","first-page":"E1564","DOI":"10.1097\/BRS.0b013e3181ef5c14","article-title":". A multicenter study to evaluate the safety and efficacy of a stand-alone anterior carbon IF Cage for anterior lumbar interbody fusion: two-year results from a Food and Drug Administration investigational device exemption clinical trial.","volume":"35","author":"Li","year":"2010","journal-title":"Spine"},{"key":"R24-12-20210204","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00586-008-0845-0","article-title":". Clinical and radiological outcome of anterior-posterior fusion versus transforaminal lumbar interbody fusion for symptomatic disc degeneration: a retrospective comparative study of 133 patients.","volume":"18","author":"Faundez","year":"2009","journal-title":"Eur Spine J"},{"key":"R26-12-20210204","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00264-008-0588-x","article-title":"Posterior lumbar interbody fusion versus posterolateral fusion in spondylolisthesis: a prospective controlled study in the Han nationality.","volume":"33","author":"Cheng","year":"2009","journal-title":"Int Orthop"},{"key":"R27-12-20210204","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00024720-200304000-00001","article-title":". Is INFUSE bone graft superior to autograft bone An integrated analysis of clinical trials using the LT-CAGE lumbar tapered fusion device.","volume":"16","author":"Burkus","year":"2003","journal-title":"J Spinal Disord Tech"},{"key":"R28-12-20210204","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.spinee.2008.01.008","article-title":"The use of bone morphogenetic protein in spine fusion.","volume":"8","author":"Hsu","year":"2008","journal-title":"Spine J"},{"key":"R29-12-20210204","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/01.brs.0000153392.74639.ea","article-title":". Pseudarthrosis in primary fusions for adult idiopathic scoliosis: incidence, risk factors, and outcome analysis.","volume":"30","author":"Kim","year":"2005","journal-title":"Spine"},{"key":"R30-12-20210204","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1097\/00007632-199306150-00006","article-title":"A prospective, randomized study of lumbar fusion. Preliminary results.","volume":"18","author":"Zdeblick","year":"1993","journal-title":"Spine"},{"key":"R31-12-20210204","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3171\/2011.4.SPINE10822","article-title":". Long-term outcomes of revision fusion for lumbar pseudarthrosis.","volume":"15","author":"Adogwa","year":"2011","journal-title":"J Neurosurg Spine"},{"key":"R33-12-20210204","doi-asserted-by":"crossref","first-page":"E680","DOI":"10.1097\/BRS.0b013e3181844eca","article-title":". Efficacy of autologous iliac crest bone graft and bone morphogenetic proteins for posterolateral fusion of lumbar spine: a meta-analysis of the results.","volume":"33","author":"Papakostidis","year":"2008","journal-title":"Spine"},{"key":"R34-12-20210204","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1097\/00007632-200206010-00002","article-title":". Chronic low back pain and fusion: a comparison of three surgical techniques: a prospective multicenter randomized study from the Swedish lumbar spine study group.","volume":"27","author":"Fritzell","year":"2002","journal-title":"Spine"},{"key":"R35-12-20210204","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1097\/00007632-200212010-00005","article-title":". Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies.","volume":"27","author":"Boden","year":"2002","journal-title":"Spine"},{"key":"R36-12-20210204","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/01.brs.0000206357.88287.5a","article-title":"Influence of rhBMP-2 on the healing patterns associated with allograft interbody constructs in comparison with autograft.","volume":"31","author":"Burkus","year":"2006","journal-title":"Spine"},{"key":"R37-12-20210204","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.spinee.2006.10.015","article-title":"Accelerating lumbar fusions by combining rhBMP-2 with allograft bone: a prospective analysis of interbody fusion rates and clinical outcomes.","volume":"7","author":"Slosar","year":"2007","journal-title":"Spine J"},{"key":"R38-12-20210204","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3171\/spi.2005.3.6.0436","article-title":". Safety of transforaminal lumbar interbody fusion and intervertebral recombinant human bone morphogenetic protein-2.","volume":"3","author":"Villavicencio","year":"2005","journal-title":"J Neurosurg Spine"},{"key":"R40-12-20210204","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1097\/BRS.0b013e31814b2d3c","article-title":". Complications in posterior fusion and instrumentation for degenerative lumbar scoliosis.","volume":"32","author":"Cho","year":"2007","journal-title":"Spine"},{"key":"R41-12-20210204","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1227\/NEU.0b013e3182338b2b","article-title":"Surgical treatment of low-grade isthmic spondylolisthesis with transsacral fibular strut grafts.","volume":"70","author":"Passias","year":"2012","journal-title":"Neurosurgery"},{"key":"R42-12-20210204","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/00007632-199004000-00014","article-title":"Simultaneous combined anterior and posterior fusion. An independent analysis of a treatment for the disabled low-back pain patient.","volume":"15","author":"Kozak","year":"1990","journal-title":"Spine"},{"key":"R43-12-20210204","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/00002517-199812000-00004","article-title":". Analysis of circumferential lumbar fusion outcome in the treatment of degenerative disc disease of the lumbar spine.","volume":"11","author":"Gertzbein","year":"1998","journal-title":"J Spinal Disord"}],"container-title":["Journal of Spinal Disorders & Techniques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/BSD.0b013e318287f2e2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T23:41:04Z","timestamp":1620949264000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00024720-201506000-00012"}},"subtitle":["A 9-Year Institutional Analysis"],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1097\/bsd.0b013e318287f2e2","relation":{},"ISSN":["1536-0652"],"issn-type":[{"value":"1536-0652","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]}}}