{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:51:14Z","timestamp":1761519074075},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11]]},"abstract":"\n Study Design:<\/jats:title>\n In vivo porcine model utilized to evaluate the influence of an intravertebral fusionless growth modulating device (hemi-staple) on intervertebral disks and growth plates.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n To evaluate the radiographic and histologic changes in disks and growth plates with the purpose of measuring influence of the explored hemi-staple.<\/jats:p>\n <\/jats:sec>\n \n Summary of Background Data:<\/jats:title>\n Fusionless growth modulation for the early treatment of scoliosis should insure the long-term viability of the intervertebral disk and successfully reduce or arrest local growth. A novel hemi-staple that proved effective in the control of coronal spinal alignment warranted further analyses of its influence on the disk health and growth-plate morphology.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A hemi-staple that inhibited local vertebral growth exclusive of the disk was introduced over T5\u2013T8 in 4 immature pigs (16 vertebrae; experimental), whereas 3 underwent surgery without instrumentation (sham) and 2 had no intervention (control). Three-month follow-up before animal euthanasia provided radiographic (disk height and health) and histologic (growth plate morphology, disk health, and type X collagen distribution) analyses.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n No postoperative complications were experienced. Radiographic data returned inverse disk wedging (greater disk height adjacent to device, 2.6\u00b10.7 mm compared with the noninstrumented side, 1.8\u00b10.5 mm) in experimental segments and suggested disk viability. Histologic data confirmed device growth modulation through significant local reduction of growth plate hypertrophic zone (125.64\u00b116.61 \u03bcm and 61.16\u00b18.25 \u03bcm in noninstrumented and instrumented sections, respectively) and cell height (16.14\u00b11.87 \u03bcm and 9.22\u00b11.57 \u03bcm in noninstrumented and instrumented sections, respectively). A variability of disk health, dependant of device insertion location, was observed. Type X collagen was consistently identified in experimental growth plates and absent from intervertebral disks.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Hemi-staples decreased growth plate hypertrophic zone and cell height, and, depending on device insertion site, showed positive signs of disk health sustainability. Spinal growth modulation achieved exclusive of disk compression, as practiced by this method, offers unique advantages over other fusionless techniques. This technique may provide a suitable and attractive alternative for the early treatment of idiopathic scoliosis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/bsd.0b013e31828b2f15","type":"journal-article","created":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T22:26:28Z","timestamp":1363991188000},"page":"457-464","source":"Crossref","is-referenced-by-count":8,"title":["Novel Hemi-Staple for the Fusionless Correction of Pediatric Scoliosis"],"prefix":"10.1097","volume":"29","author":[{"given":"Mark","family":"Driscoll","sequence":"first","affiliation":[{"name":"\u00c9cole Polytechnique de Montr\u00e9al, Biomedical Engineering Institute"},{"name":"Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl-\u00c9ric","family":"Aubin","sequence":"additional","affiliation":[{"name":"\u00c9cole Polytechnique de Montr\u00e9al, Biomedical Engineering Institute"},{"name":"Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Moreau","sequence":"additional","affiliation":[{"name":"Laboratory in Molecular Genetics of Musculoskeletal Diseases, Sainte-Justine University Hospital Center"},{"name":"Stomatology, Faculty of Dentistry"},{"name":"Biochemistry, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaroslav","family":"Wakula","sequence":"additional","affiliation":[{"name":"Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira","family":"Amini","sequence":"additional","affiliation":[{"name":"Research Center"},{"name":"Laboratory in Molecular Genetics of Musculoskeletal Diseases, Sainte-Justine University Hospital Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Parent","sequence":"additional","affiliation":[{"name":"Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230831","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1097\/00007632-199605150-00007","article-title":"Mechanical modulation of vertebral body growth. 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