{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:02:54Z","timestamp":1762506174968},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8]]},"abstract":"\n Study Design:<\/jats:title>\n Retrospective study.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n Assessment of the impact of cement placement and leakage in osteoporotic vertebral compression fractures (OVCFs) followed by percutaneous vertebroplasty (PVP) on patient pain relief and new vertebral fracture occurrence.<\/jats:p>\n <\/jats:sec>\n \n Summary of Background Data:<\/jats:title>\n Previous studies have not specifically addressed cement placement in the context of pain outcomes and subsequent vertebral fracture.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We included a total of 192 patients who underwent PVP for OVCFs. We assessed imaging data, and patients rated their pain over a 24-month period. The patients were divided into 3 groups based on image analysis: group 1 [31 cases: 5 thoracic, 15 thoracolumbar (TL) junction, 11 lumbar] included patients with no cement extension to the endplate(s), group 2 (121 cases: 19 thoracic, 64 TL junction, 38 lumbar) was comprised of patients with cement extension to the endplate(s) but no leakage into the disk space, and group 3 (40 cases: 8 thoracic, 21 TL junction, 11 lumbar) included patients with cement extension to the endplate(s) and leakage into the disk space(s). We assessed the correlation between cement location and pain ratings and changes in pain scores, as well as the proportions of new fracture.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Postprocedure pain numeric scores and changes in pain scores were similar among the 3 groups (P<\/jats:italic>>0.05). Cement location did not significantly correlate with pain ratings or changes in pain scores for any follow-up points. There was no significant difference in new adjacent fracture rate among the groups (P<\/jats:italic>>0.05).<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Neither extension of cement to the endplate nor cement leakage into the disk space had a significant impact on postprocedural pain. Furthermore, intradisk cement leakage was not a risk factor for new fracture after PVP in patients with OVCF. However, lower fill volumes should be used to lessen the risk of leakage.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/bsd.0b013e3182aa28d6","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T17:53:47Z","timestamp":1378317227000},"page":"E365-E370","source":"Crossref","is-referenced-by-count":13,"title":["Impact of Cement Placement and Leakage in Osteoporotic Vertebral Compression Fractures Followed by Percutaneous Vertebroplasty"],"prefix":"10.1097","volume":"29","author":[{"given":"Xiaobin","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jixin","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230831","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1097\/01.brs.0000229254.89952.6b","article-title":"Vertebroplasty and kyphoplasty: a systematic review of 69 clinical studies","volume":"31","author":"Hulme","year":"2006","journal-title":"Spine"},{"key":"R2-20230831","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1148\/radiol.2261011911","article-title":"Occurrence of new vertebral body fracture after percutaneous vertebroplasty in patients with osteoporosis","volume":"226","author":"Uppin","year":"2003","journal-title":"Radiology"},{"key":"R3-20230831","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pain.2004.09.012","article-title":"Core outcome measures for chronic pain clinical trials: IMMPACT recommendations","volume":"113","author":"Dworkin","year":"2005","journal-title":"Pain"},{"key":"R4-20230831","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s001980170086","article-title":"Treatment of painful osteoporotic vertebral fractures with percutaneous vertebroplasty or kyphoplasty","volume":"12","author":"Watts","year":"2001","journal-title":"Osteoporos Int"},{"issue":"suppl","key":"R5-20230831","first-page":"90","article-title":"Surgical removal of epidural and intradural polymethylmethacrylate extravasation complicating percutaneous vertebroplasty for an osteoporotic lumbar compression fracture. Case report","volume":"98","author":"Shapiro","year":"2003","journal-title":"J Neurosurg"},{"key":"R6-20230831","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1097\/00007632-200107150-00002","article-title":"New technologies in spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures","volume":"26","author":"Garfin","year":"2001","journal-title":"Spine"},{"key":"R7-20230831","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1097\/01.brs.0000216461.48751.d6","article-title":"Intradiscal cement leak following percutaneous vertebroplasty","volume":"31","author":"Mirovsky","year":"2006","journal-title":"Spine"},{"key":"R8-20230831","doi-asserted-by":"crossref","first-page":"E419","DOI":"10.1097\/BRS.0b013e318074d4b9","article-title":"The influence of endplate- to endplate cement augmentation on vertebral strength and stiffness in vertebroplasty","volume":"32","author":"Steens","year":"2007","journal-title":"Spine"},{"key":"R9-20230831","first-page":"175","article-title":"Vertebroplasty: cement leakage into the disc increases the risk of new fracture of adjacent vertebral body","volume":"25","author":"Lin","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"R10-20230831","first-page":"2397","article-title":"Intradiskal extravasation with low-volume cement filling in percutaneous vertebroplasty","volume":"26","author":"Syed","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"R11-20230831","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00330-007-0694-y","article-title":"CT-guided vertebroplasty in osteoporotic vertebral fractures: incidence of secondary fractures and impact of intradiscal cement leakages during follow-up","volume":"18","author":"Pitton","year":"2008","journal-title":"Eur Radiol"},{"key":"R12-20230831","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3171\/SPI\/2008\/9\/8\/129","article-title":"Predictive factors for subsequent vertebral fracture after percutaneous vertebroplasty","volume":"9","author":"Ahn","year":"2008","journal-title":"J Neurosurg Spine"},{"key":"R13-20230831","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s00586-004-0839-5","article-title":"Cement leakage during vertebroplasty: an underestimated problem","volume":"14","author":"Schmidt","year":"2005","journal-title":"Eur Spine J"},{"key":"R14-20230831","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1148\/radiol.2231010234","article-title":"Percutaneous vertebroplasty for severe osteoporotic vertebral compression fractures","volume":"223","author":"Peh","year":"2002","journal-title":"Radiology"}],"container-title":["Clinical Spine Surgery: A Spine Publication"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/01933606-201608000-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T18:22:21Z","timestamp":1693506141000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01933606-201608000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1097\/bsd.0b013e3182aa28d6","relation":{},"ISSN":["2380-0186"],"issn-type":[{"value":"2380-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]}}}