{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:13:26Z","timestamp":1789658006713,"version":"4.0.1"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4]]},"abstract":"\n Study Design:<\/jats:title>\n Eleven patients with painful osteoporotic vertebral fractures who underwent kyphoplasty using calcium phosphate (CaP) cement were followed up for 1 week, 1, 2, and 3 years in a monocentric, nonrandomized, noncontrolled retrospective trial.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n This study investigates long-term radiomorphologic features of intraosseous CaP cement implants and of extraosseous CaP cement leakages for up to 3 years after implantation by kyphoplasty.<\/jats:p>\n <\/jats:sec>\n \n Summary of Background Data:<\/jats:title>\n Kyphoplasty is frequently used for the treatment of painful osteoporotic fractures. Of the materials available, CaP is frequently used as a filling material. Resorption of this material is frequently observed, although clinical outcome is comparable with other cements.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Kyphoplasty utilizing CaP cement was performed in 11 patients with painful osteoporotic vertebral fractures. All patients received a pharmacological antiosteoporosis treatment consisting of calcium, vitamin D, and a standard dose of oral bisphosphonates. Radiomorphologic measurements, pain, and mobility were assessed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Intraosseous and extraosseous CaP cement volumes decreased significantly over 3 years. However, vertebral stability as determined by a constant vertebral body height and the sagittal index was not impaired. Pain improved significantly 2 years after implantation and the mobility scores 1 year after kyphoplasty at least until the third year.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Intravertebral CaP cement implants are resorbed slowly over time without jeopardizing stability and clinical outcomes most likely because of a slowly progressing osseous replacement. Extraosseous CaP cement material because of leakages during the kyphoplasty procedure is almost completely resorbed as early as 2 years after the leakage occurred. Therefore, CaP cement is an important alternative to PMMA-based cement materials utilized for kyphoplasty of osteoporotic vertebral fractures.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/bsd.0b013e3182aab2df","type":"journal-article","created":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T07:11:41Z","timestamp":1380611501000},"page":"E291-E296","source":"Crossref","is-referenced-by-count":17,"title":["Osteointegration and Resorption of Intravertebral and Extravertebral Calcium Phosphate Cement"],"prefix":"10.1097","volume":"30","author":[{"given":"Roman","family":"Klein","sequence":"first","affiliation":[{"name":"Medicine I and Clinical Chemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Tetzlaff","sequence":"additional","affiliation":[{"name":"Radiology, University of Heidelberg, Heidelberg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Weiss","sequence":"additional","affiliation":[{"name":"Institute of 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