{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:18:49Z","timestamp":1790403529171,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1097\/cad.0b013e3283592da8","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T03:35:43Z","timestamp":1346988943000},"page":"73-83","source":"Crossref","is-referenced-by-count":18,"title":["The pterocarpanquinone LQB 118 induces apoptosis in tumor cells through the intrinsic pathway and the endoplasmic reticulum stress pathway"],"prefix":"10.1097","volume":"24","author":[{"given":"Thiago","family":"de S\u00e1 Bacelar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alcides J.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo R.R.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian M.","family":"Rumjanek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20210227","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.bmc.2009.12.073","article-title":"New pterocarpanquinones: synthesis, antineoplasic activity on cultured human malignant cell lines and TNF- modulation in human PBMC.","volume":"18","author":"Netto","year":"2010","journal-title":"Bioorg Med Chem"},{"key":"R2-8-20210227","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s10637-010-9453-z","article-title":"LQB-118, a pterocarpanquinone structurally related to lapachol 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphtoquinone: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells.","volume":"29","author":"Maia","year":"2011","journal-title":"Invest New Drugs"},{"key":"R4-8-20210227","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1177\/1534735405276191","article-title":"Coenzyme Q10 for prevention of anthracycline-induced cardiotoxicity.","volume":"4","author":"Conklin","year":"2005","journal-title":"Integr Cancer Ther"},{"key":"R5-8-20210227","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/1074-5521(95)90120-5","article-title":"Small, fast and deadly (but very selective).","volume":"2","author":"Tomasz","year":"1995","journal-title":"Chem Biol"},{"key":"R6-8-20210227","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/toxsci\/kfq150","article-title":"Benzoapyrene increases the Nrf2 content by downregulating the Keap1 message.","volume":"116","author":"Nguyen","year":"2010","journal-title":"Toxicol Sci"},{"key":"R7-8-20210227","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.freeradbiomed.2009.11.016","article-title":"Evidence for NAD(p)H: quinone oxidoreductase 1 (NQO1)-mediated quinone-dependent redox cycling via plasma membrane electron transport: a sensitive cellular assay for NQO1.","volume":"48","author":"Tan","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"R9-8-20210227","first-page":"81","article-title":"Imunocytochemical study of Bcr and Bcr-Abl localization in K562 cells.","volume":"32","author":"Telegeev","year":"2010","journal-title":"Exp Oncol"},{"key":"R10-8-20210227","doi-asserted-by":"crossref","first-page":"14337","DOI":"10.1074\/jbc.M611019200","article-title":"Gluthathione export during apoptosis requires functional multidrug resistance-associated proteins.","volume":"282","author":"Hammond","year":"2007","journal-title":"J Biol Chem"},{"key":"R11-8-20210227","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1038\/sj.onc.1201704","article-title":"BAX frameshift mutations in cell lines derived from human haemopoietic malignancies associated with resistance to apoptosis and microsatellite instability.","volume":"16","author":"Brimmell","year":"1998","journal-title":"Oncogene"},{"key":"R12-8-20210227","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1182\/blood.V91.3.991.991_991_1000","article-title":"Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse.","volume":"91","author":"Kaufmann","year":"1998","journal-title":"Blood"},{"key":"R13-8-20210227","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1182\/blood-2008-05-157842","article-title":"Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells.","volume":"113","author":"Hulleman","year":"2009","journal-title":"Blood"},{"key":"R14-8-20210227","first-page":"1299","article-title":"Involvement of endoplasmic reticulum stress and activation of MAP kinases in beta-lapachone-induced human prostate cancer cell apoptosis.","volume":"23","author":"Lien","year":"2008","journal-title":"Histol Histopathol"},{"key":"R15-8-20210227","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.abb.2010.03.019","article-title":"NAD(P)H: quinone aceptor oxidoreductase 1 (NQO1), a multifunctional antioxidante enzyme and exceptionally versatile cytoprotector.","volume":"501","author":"Dinkova-Kostova","year":"2010","journal-title":"Arch Biochem Biophys"},{"key":"R16-8-20210227","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00689804","article-title":"NAD(P)H: quinone oxidoreductase 1 (DT-diaphorase) expression in normal and tumor tissues.","volume":"12","author":"Belinsky","year":"1993","journal-title":"Cancer Metastasis Rev"},{"key":"R17-8-20210227","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0009-2797(00)00199-X","article-title":"NAD(P)H: quinone oxidoreductase 1 (NQO1) chemoprotection, bioactivation, gene regulation and genetic polymorphisms.","volume":"1","author":"Ross","year":"2000","journal-title":"Chem Biol Interact"},{"key":"R18-8-20210227","first-page":"45","article-title":"Mitomycin C.","volume":"14","author":"Gibson","year":"1993","journal-title":"Cancer Chemother Biol Response Modif"},{"key":"R19-8-20210227","doi-asserted-by":"crossref","first-page":"8350","DOI":"10.1021\/jo991301y","article-title":"A Novel class of CC-1065 and duocarmycin analogues subject to mitomycin-related reductive activation.","volume":"64","author":"Boger","year":"1999","journal-title":"J Org Chem"},{"key":"R20-8-20210227","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1042\/BSR20110062","article-title":"Requirement for store-operated calcium entry in sodium butyrate-induced apoptosis in human colon cancer cells.","volume":"32","author":"Sun","year":"2011","journal-title":"Biosci Rep"},{"key":"R21-8-20210227","doi-asserted-by":"crossref","first-page":"13638","DOI":"10.1074\/jbc.M110.201889","article-title":"Endoplasmic reticulum stress-induced apoptosis in Leishmania through Ca2-dependent and caspase-independent mechanism.","volume":"286","author":"Dolai","year":"2011","journal-title":"J Biol Chem"},{"key":"R22-8-20210227","doi-asserted-by":"crossref","first-page":"13935","DOI":"10.1074\/jbc.M010677200","article-title":"Activation of caspase-12, an endoplasmic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated fator-2-dependent mechanism in response to the ER stress.","volume":"276","author":"Yoneda","year":"2001","journal-title":"J Biol Chem"},{"key":"R23-8-20210227","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3858\/emm.2010.42.5.040","article-title":"Induction of the unfolded protein response and cell death pathway in Alzheimers disease, but not in aged Tg2576 mice.","volume":"42","author":"Lee","year":"2010","journal-title":"Exp Mol Med"},{"key":"R24-8-20210227","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00592-009-0170-z","article-title":"The role of endoplasmic reticulum stress in the early stage of diabetic retinopathy.","volume":"48","author":"Li","year":"2011","journal-title":"Acta Diabetol"},{"key":"R25-8-20210227","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.febslet.2009.04.007","article-title":"Endoplasmic reticulum is implicated in retinal inflammation and diabetic retinopathy.","volume":"583","author":"Li","year":"2009","journal-title":"FEBS Lett"},{"key":"R26-8-20210227","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/jcb.22927","article-title":"FPTB, a novel CA-4 derivative, induces cell apoptosis of human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress pathways.","volume":"112","author":"Liu","year":"2011","journal-title":"J Cell Biochem"},{"key":"R27-8-20210227","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.taap.2009.08.024","article-title":"Mollugin induces apoptosis in human Jurkat T cells through endoplasmic reticulum stress-mediated activation of JNK and caspase-12 and subsequent activation of mitochondria-dependent caspase cascade regulated by Bcl-xL.","volume":"241","author":"Kim","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"R28-8-20210227","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/sj.cdd.4401378","article-title":"Coupling endoplasmic reticulum stress to the cell death program.","volume":"11","author":"Bredesen","year":"2004","journal-title":"Cell Death Differ"},{"key":"R29-8-20210227","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bbamcr.2010.09.016","article-title":"Involvement of caspase-9 in autophagy-mediated cell survival pathway.","volume":"1813","author":"Jeong","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"R30-8-20210227","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11010-011-1033-9","article-title":"Lysosomal membrane permeabilization is involved in curcumin-induced apoptosis of A549 lung carcinoma cells.","volume":"359","author":"Chen","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"R31-8-20210227","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s11064-011-0620-1","article-title":"Synergistic effect of arsenic trioxide and silibinin on apoptosis and invasion in human glioblastoma U87MG cell line.","volume":"37","author":"Dizaji","year":"2012","journal-title":"Neurochem Res"}],"container-title":["Anti-Cancer Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/CAD.0b013e3283592da8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:00:15Z","timestamp":1786039215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001813-201301000-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/cad.0b013e3283592da8","relation":{},"ISSN":["0959-4973"],"issn-type":[{"value":"0959-4973","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}