{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:28:25Z","timestamp":1791102505877,"version":"4.1.0"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1097\/cad.0b013e32835dc7c5","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T10:47:32Z","timestamp":1358333252000},"page":"415-421","source":"Crossref","is-referenced-by-count":15,"title":["Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors"],"prefix":"10.1097","volume":"24","author":[{"given":"Don W.","family":"Coulter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Walko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billie M.","family":"Moats-Staats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McFadden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott V.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasiuddin A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene S.","family":"Bridges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison M.","family":"Deal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Oesterheld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Blatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R5-10-20210227","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/CAD.0b013e3283442074","article-title":"Temsirolimus in advanced leiomyosarcomas: patterns of response and correlation with the activation of the mammalian target of rapamycin pathway.","volume":"22","author":"Italiano","year":"2011","journal-title":"Anticancer Drugs"},{"key":"R10-10-20210227","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1055\/s-2004-814153","article-title":"Insulin-like growth factor binding protein-6 and CCI-779, an ester analogue of rapamycin, additively inhibit rhabdomyosarcoma growth.","volume":"35","author":"Gallicchio","year":"2003","journal-title":"Horm Metab Res"},{"key":"R12-10-20210227","first-page":"1509","article-title":"IGF-I receptor inhibition combined with rapamycin or temsirolimus inhibits neuroblastoma cell growth.","volume":"28","author":"Coulter","year":"2008","journal-title":"Anticancer Res"},{"key":"R15-10-20210227","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1002\/ijc.22401","article-title":"Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood.","volume":"120","author":"Furchert","year":"2007","journal-title":"Int J Cancer"},{"key":"R17-10-20210227","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/med.10017","article-title":"Anti-tumor mechanisms of valproate: a novel role for an old drug.","volume":"22","author":"Blaheta","year":"2002","journal-title":"Med Res Rev"},{"key":"R24-10-20210227","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1212\/WNL.63.10_suppl_4.S3","article-title":"Pharmacogenetics and enzyme inductioninhibition properties of antiepileptic drugs.","volume":"63","author":"Anderson","year":"2004","journal-title":"Neurology"},{"key":"R26-10-20210227","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10637-010-9570-8","article-title":"A phase I study of temsirolimus and metformin in advanced solid tumours.","volume":"30","author":"Mackenzie","year":"2012","journal-title":"Invest New Drugs"}],"container-title":["Anti-Cancer Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/CAD.0b013e32835dc7c5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T23:18:00Z","timestamp":1620947880000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00001813-201304000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/cad.0b013e32835dc7c5","relation":{},"ISSN":["0959-4973"],"issn-type":[{"value":"0959-4973","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}