{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:58:27Z","timestamp":1767164307117,"version":"build-2238731810"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>To identify COVID-19-associated immunophenotyping patterns at hospital admission and to determine if some patterns could predict the need for mechanical ventilation (MV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN:<\/jats:title>\n                    <jats:p>Prospective observational monocentric cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING:<\/jats:title>\n                    <jats:p>A university-affiliated hospital in Marseille, France.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS:<\/jats:title>\n                    <jats:p>Thirty patients presenting with laboratory-confirmed COVID-19 pneumonia were enrolled within the first 48 hours of hospital admission and compared with 18 healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>INTERVENTIONS:<\/jats:title>\n                    <jats:p>None.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MEASUREMENTS AND MAIN RESULTS:<\/jats:title>\n                    <jats:p>\n                      Whole-blood leukocytes were immunophenotyped with a rapid and simplified one-step flow cytometry method. Thirty-eight immune and five laboratory parameters were compared first between COVID-19 patients and controls and then between the COVID-19 patients who received or not MV during their stays. The variables that significantly discriminated MV from non-MV patients in univariate analysis were entered into a multiple stepwise logistic regression analysis. The COVID-19 patients were predominantly male (87%), aged 61 years (50\u201371 yr), and 93% received early corticosteroid therapy. Sixteen patients (53%) were managed with noninvasive respiratory support, and 14 (47%) required MV. Compared with controls, COVID-19 patients were characterized by an immune signature featuring: 1) decreased HLA-DR expression on monocytes; 2) reduced basophils, eosinophils, T-cells, NK cells, and nonclassical monocyte count; and 3) up regulation of CD169 on monocytes, CD64 on neutrophils, the adhesion\/migration markers (CD62L and CD11b), and the checkpoint inhibitor CD274 on myeloid cells. Among the COVID-19 patients, those who received MV had lower level of CD4 and HLA-DR on monocytes, lower CD8+ T-cell count, and higher lactate dehydrogenase at hospital admission. In multivariate analysis, only CD4 on monocytes (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.032) and CD8+ T-cell count (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.026) were associated with MV requirement. The model combining these two variables provided an area under curve of 0.97 (95% CI, 0.83\u20130.99).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The association of low CD4 on monocytes and low CD8+ T-cell count at hospital admission was highly predictive of the need for MV in hospitalized patients with COVID-19 pneumonia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/cce.0000000000000810","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T11:01:51Z","timestamp":1670410911000},"page":"e0810","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["The Association of Low CD4 Expression on Monocytes and Low CD8+ T-Cell Count at Hospital Admission Predicts the Need for Mechanical Ventilation in Patients With COVID-19 Pneumonia: A Prospective Monocentric Cohort Study"],"prefix":"10.1097","volume":"4","author":[{"given":"J\u00e9r\u00f4me","family":"Allardet-Servent","sequence":"first","affiliation":[{"name":"Service de R\u00e9animation, H\u00f4pital Europ\u00e9en, Marseille, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Ait Belkacem","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, Centre d\u2019Immunologie de Marseille-Luminy, Marseille, France."},{"name":"Department of Research and Development, Beckman Coulter Life Sciences-Immunotech, Marseille, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tewfik","family":"Miloud","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Beckman Coulter Life Sciences-Immunotech, Marseille, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Benarous","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation, H\u00f4pital Europ\u00e9en, Marseille, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franck","family":"Galland","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, Centre d\u2019Immunologie de Marseille-Luminy, Marseille, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Halfon","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et M\u00e9decine Interne, H\u00f4pital Europ\u00e9en, Marseille, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"M\u00e8ge","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Immunologie, Institut Hospitalo-Universitaire de Maladies Infectieuses, APHM, Marseille, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Penaranda","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Alphabio 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