{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:19:28Z","timestamp":1786119568253,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>To ascertain the potential effects of hypoxemia and race on pulse oximetry in a population of patients, including those for whom hypoxemia is a normal state secondary to intracardiac mixing in an ICU setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN:<\/jats:title>\n                    <jats:p>Retrospective, observational, cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING:<\/jats:title>\n                    <jats:p>A single center\u2019s pediatric cardiac ICU (CICU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS:<\/jats:title>\n                    <jats:p>Eight hundred forty-one patients undergoing bypass operations during a 52-month period (June 2019\u2013October 2023). Predominantly, patients with congenital heart disease. The median age was 7.1 months with 58% younger than 1 year old and 88% younger than 10 years old.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>INTERVENTIONS:<\/jats:title>\n                    <jats:p>Arterial blood saturations, as measured by a hemoximeter, were recorded for all patients after bypass operations. These were time-matched, with high-fidelity, to pulse oximeter values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MEASUREMENTS AND MAIN RESULTS:<\/jats:title>\n                    <jats:p>\n                      The mean oximetric difference, or \u201cpulse oximetry overestimation,\u201d was defined as arterial oxygen saturation minus that predicted by pulse oximetry, was greater for Black than for White patients (\u20133.18% vs. \u20132.19%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.006). Regression shows a significant effect of Sa\n                      <jats:sc>o<\/jats:sc>\n                      <jats:sub>2<\/jats:sub>\n                      on oximetric difference (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) and mildly significant trend for the categorical race (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.03) as well as their composite interaction term (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.047). Oximetric difference was exaggerated with increasing hypoxemia. At normal oxygen saturations, the oximetric difference was greater for Black when compared with White patients (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.002 for patients with Sa\n                      <jats:sc>o<\/jats:sc>\n                      <jats:sub>2<\/jats:sub>\n                      &gt; 94%). This effect if race is not statistically significant at other Sa\n                      <jats:sc>o<\/jats:sc>\n                      <jats:sub>2<\/jats:sub>\n                      ranges that are clinically important in patients with intracardiac mixing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>This study redemonstrates effect of increasing hypoxemia on oximetric difference. Race may have an independent effect on oximetric difference. This adds to the body of literature that has previously suggested that pulse oximetry, relied upon as a vital sign, may introduce explicit race-related bias into the bedside interpretation of a patient\u2019s clinical state.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/cce.0000000000001237","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T21:25:00Z","timestamp":1742851500000},"page":"e1237","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Race and the Inaccuracy of Pulse Oximetry With Hypoxemia in a Pediatric Cardiac ICU"],"prefix":"10.1097","volume":"7","author":[{"given":"Matthew T.","family":"Coghill","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology, Section of Cardiac Critical Care, University of Alabama at Birmingham, Birmingham, AL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Section of Cardiac Critical Care, University of Alabama at Birmingham, Birmingham, AL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lece V.","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Pediatric Critical Care, Section of Cardiac Critical Care, University of Alabama at Birmingham, Birmingham, AL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Asfari","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Section of Cardiac Critical Care, University of Alabama at Birmingham, Birmingham, AL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Borasino","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Section of Cardiac Critical Care, University of Alabama at Birmingham, Birmingham, 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