{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:23:48Z","timestamp":1782948228813,"version":"3.54.5"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n            <jats:title>Objectives:<\/jats:title>\n            <jats:p>To describe an unusual complication on extracorporeal membrane oxygenation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Data Sources:<\/jats:title>\n            <jats:p>Clinical observation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Study Selection:<\/jats:title>\n            <jats:p>Case report.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Data Extraction:<\/jats:title>\n            <jats:p>Relevant clinical information.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Data Synthesis:<\/jats:title>\n            <jats:p>We report the cases of three young patients who developed extensive myocardial calcifications on prolonged extracorporeal membrane oxygenation support for severe acute respiratory distress syndrome with septic cardiomyopathy, postresuscitation cardiogenic shock, and septic shock complicating severe acute respiratory distress syndrome, respectively. Extensive myocardial calcifications were confirmed by echocardiography, CT, and cardiac biopsy. The combination of multiple factors, for example, prolonged hemodynamic failure, profound acidosis, high vasopressor doses, and renal failure, may lead to this unusual and severe complication.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Intensivists should be aware of this rare but rapid complication on extracorporeal membrane oxygenation support that may directly impact outcome. The precise role of extracorporeal membrane oxygenation support in the timing and frequency of new-onset diffuse myocardial calcification deserves further investigation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/ccm.0000000000003130","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T11:29:32Z","timestamp":1521718172000},"page":"e702-e706","source":"Crossref","is-referenced-by-count":16,"title":["Extensive Myocardial Calcification in Critically Ill Patients"],"prefix":"10.1097","volume":"46","author":[{"given":"Natacha","family":"Kapandji","sequence":"first","affiliation":[{"name":"Medical Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Redheuil","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Paris, France."},{"name":"Department of Cardiovascular Imaging, Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Fouret","sequence":"additional","affiliation":[{"name":"Department of Anatomopathology, Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"H\u00e9kimian","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France."},{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Lebreton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Br\u00e9chot","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France."},{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles-Edouard","family":"Luyt","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France."},{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Cluzel","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Paris, France."},{"name":"Department of Cardiovascular Imaging, Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Combes","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France."},{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France."},{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230728","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s00134-016-4273-z","article-title":"Extracorporeal membrane oxygenation: Evolving epidemiology and mortality.","volume":"42","author":"Karagiannidis","year":"2016","journal-title":"Intensive Care Med"},{"key":"R2-20230728","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jcct.2014.10.004","article-title":"Myocardial calcifications: Pathophysiology, etiologies, differential diagnoses, and imaging findings.","volume":"9","author":"Nance","year":"2015","journal-title":"J Cardiovasc Comput 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