{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:02:48Z","timestamp":1777874568613,"version":"3.51.4"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To identify factors associated with short-term mortality among patients receiving microaxial flow pump (mAFP) therapy for acute myocardial infarction-related cardiogenic shock (AMI-CS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources:<\/jats:title>\n                    <jats:p>We searched four databases (MEDLINE, Embase, CENTRAL, and Scopus) from January 1, 2004, to January 1, 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection:<\/jats:title>\n                    <jats:p>We selected English-language studies that included adults with AMI-CS receiving mAFP and evaluated factors associated with short-term mortality. We excluded patients receiving concurrent venoarterial extracorporeal membrane oxygenation, as well as studies that solely included patients presenting with out-of-hospital cardiac arrest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction:<\/jats:title>\n                    <jats:p>Two authors performed citation screening and data extraction. For each factor evaluated in at least two studies, we performed meta-analyses of adjusted odds ratios (aORs) using a random-effects model. Risk of bias was evaluated using the Quality in Prognosis Studies tool, and the certainty of evidence was evaluated using Grading of Recommendations, Assessment, Development, and Evaluations methodology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis:<\/jats:title>\n                    <jats:p>Our primary analysis included 18 studies, encompassing 20,617 patients. Median short-term mortality across studies was 50.7% (interquartile range 38.4\u201355.3%). Factors associated with short-term mortality based on high-certainty evidence included: increased age (aOR, 1.04 per year [95% CI, 1.03\u20131.05 per year] or \u2265 65 yr (aOR, 2.42 yr [95% CI, 0.77\u20137.64 yr]), female sex (aOR, 1.26 [95% CI, 1.09\u20131.45]), higher body mass index (aOR, 1.05 per point [95% CI, 1.04\u20131.07 per point]), higher heart rate (aOR, 1.02 per beats\/min [95% CI, 1.01\u20131.02 per beats\/min]), higher serum creatinine (aOR, 1.35 per mg\/dL [95% CI, 1.08\u20131.70 per mg\/dL]), mechanical ventilation (aOR, 2.53 [95% CI, 1.82\u20133.53]), vasopressors (aOR, 1.52 [95% CI, 1.11\u20132.08] for any vasopressors and aOR, 1.37 [95% CI, 1.18\u20131.58] per each vasopressor), presentation with ST-elevation myocardial infarction (aOR, 1.59 [95% CI, 1.11\u20132.26]), cardiac arrest (aOR, 2.85 [95% CI, 2.22\u20133.64]), and hypoxic-ischemic brain injury (aOR, 5.36 [95% CI, 3.03\u20139.47]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We identified several prognostic factors associated with short-term mortality in AMI-CS patients receiving mAFP support. This work may help inform clinicians, patients, and families regarding utilization of mAFP in AMI-CS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/ccm.0000000000007013","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T15:00:14Z","timestamp":1767884414000},"page":"584-593","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Factors Among Patients Receiving Microaxial Flow Pump for Acute Myocardial Infarction-Related Cardiogenic Shock: A Systematic Review and Meta-Analysis"],"prefix":"10.1097","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9294-4268","authenticated-orcid":false,"given":"Simon","family":"Parlow","sequence":"first","affiliation":[{"name":"CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, ON, Canada."},{"name":"Department of Critical Care Medicine, University of Ottawa, Ottawa, ON, Canada."},{"name":"Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard G.","family":"Jung","sequence":"additional","affiliation":[{"name":"CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, ON, Canada."},{"name":"Department of Medicine, University of Ottawa, Ottawa, ON, Canada."},{"name":"Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayed Abdulmotaleb","family":"Almoosawy","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa, Ottawa, ON, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa Fay","family":"Lepage-Ratte","sequence":"additional","affiliation":[{"name":"CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, ON, Canada."},{"name":"Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Durr","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa, Ottawa, ON, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Eve","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa, Ottawa, ON, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Di Santo","sequence":"additional","affiliation":[{"name":"CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, ON, Canada."},{"name":"Department of Critical Care Medicine, University of Ottawa, Ottawa, ON, Canada."},{"name":"Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada."},{"name":"School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pouya","family":"Motazedian","sequence":"additional","affiliation":[{"name":"CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, ON, Canada."},{"name":"Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee H.","family":"Sterling","sequence":"additional","affiliation":[{"name":"CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, ON, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Abdel-Razek","sequence":"additional","affiliation":[{"name":"CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, ON, Canada."},{"name":"Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eddy","family":"Fan","sequence":"additional","affiliation":[{"name":"Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada."},{"name":"Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada."},{"name":"Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Center Leipzig at Leipzig University and Leipzig Heart Science, Leipzig, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Price","sequence":"additional","affiliation":[{"name":"Adult Intensive Care Unit, Royal Brompton & Harefield Hospitals, London, United Kingdom."},{"name":"National Heart and Lung Institute, Imperial College, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"van Diepen","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine and Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada."},{"name":"Canadian dVIGOUR Centre, University of Alberta, Edmonton, AB, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Visintini","sequence":"additional","affiliation":[{"name":"Berkman Library, University of Ottawa Heart Institute, Ottawa, ON, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mir B.","family":"Basir","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Henry Ford Hospital, Detroit, MI."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navin K.","family":"Kapur","sequence":"additional","affiliation":[{"name":"The Cardiovascular Center, Tufts Medical Center, Boston, MA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Hibbert","sequence":"additional","affiliation":[{"name":"CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, ON, Canada."},{"name":"Department of Cardiovascular Diseases, Mayo Clinic School of Medicine, Rochester, MN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, University of Ottawa, Ottawa, ON, Canada."},{"name":"Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada."},{"name":"Department of Surgery, University of Ottawa, Ottawa, ON, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob E.","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet, Copenhagen, Denmark."},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bram","family":"Rochwerg","sequence":"additional","affiliation":[{"name":"Division of Critical Care, Department of Medicine, McMaster University, Hamilton, ON, Canada."},{"name":"Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Mathew","sequence":"additional","affiliation":[{"name":"CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, ON, Canada."},{"name":"Department of Critical Care Medicine, University of Ottawa, Ottawa, ON, Canada."},{"name":"Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4549-4289","authenticated-orcid":false,"given":"Shannon M.","family":"Fernando","sequence":"additional","affiliation":[{"name":"CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, ON, Canada."},{"name":"Department of Critical Care, Lakeridge Health, Oshawa, ON, Canada."},{"name":"Department of Critical Care Medicine, Queen\u2019s University, Kingston, ON, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"R1-20260430","doi-asserted-by":"crossref","first-page":"e232","DOI":"10.1161\/CIR.0000000000000525","article-title":"Contemporary management of cardiogenic shock: A scientific statement from the American Heart Association.","volume":"136","author":"Van 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