{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:20:46Z","timestamp":1791141646046,"version":"4.1.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Critical Care Medicine"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1097\/ccm.0b013e3181b4a76b","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T08:34:32Z","timestamp":1261038872000},"page":"223-241","source":"Crossref","is-referenced-by-count":37,"title":["Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses"],"prefix":"10.1097","volume":"38","author":[{"given":"Kevin W.","family":"McConnell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan E.","family":"McDunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Michael","family":"Dunne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaiah R.","family":"Turnbull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"DiPasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Osberghaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Sherman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Perren","family":"Cobb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy G.","family":"Buchman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Hotchkiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig M.","family":"Coopersmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-33-20160304","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJM200103083441001","volume":"344","author":"Bernard","year":"2001","journal-title":"N Engl J Med"},{"key":"R3-33-20160304","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1182\/blood-2006-06-032961","volume":"109","author":"Elson","year":"2007","journal-title":"Blood"},{"key":"R4-33-20160304","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1189\/jlb.0306170","volume":"81","author":"Foell","year":"2007","journal-title":"J Leukoc Biol"},{"key":"R5-33-20160304","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ni1004-971","volume":"5","author":"Hoebe","year":"2004","journal-title":"Nat Immunol"},{"key":"R6-33-20160304","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1097\/CCM.0b013e3181692c0b","volume":"36","author":"Tang","year":"2008","journal-title":"Crit Care Med"},{"key":"R7-33-20160304","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1097\/CCM.0b013e31819b52fd","volume":"37","author":"Tang","year":"2009","journal-title":"Crit Care Med"},{"key":"R8-33-20160304","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1001\/archsurg.1987.01400130027003","volume":"122","author":"Deutschman","year":"1987","journal-title":"Arch Surg"},{"key":"R9-33-20160304","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1001\/archsurg.1980.01380020006003","volume":"115","author":"Fry","year":"1980","journal-title":"Arch Surg"},{"key":"R10-33-20160304","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1097\/CCM.0b013e31816a11e9","volume":"36","author":"Fry","year":"2008","journal-title":"Crit Care Med"},{"key":"R11-33-20160304","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1189\/jlb.0806542","volume":"81","author":"Rittirsch","year":"2007","journal-title":"J Leukoc Biol"},{"key":"R12-33-20160304","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1164\/rccm.200211-1278OC","volume":"169","author":"Yu","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"R13-33-20160304","doi-asserted-by":"crossref","first-page":"5803","DOI":"10.1128\/IAI.71.10.5803-5813.2003","volume":"71","author":"Feezor","year":"2003","journal-title":"Infect Immun"},{"key":"R14-33-20160304","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/01.sla.0000251619.10648.32","volume":"245","author":"Johnson","year":"2007","journal-title":"Ann Surg"},{"key":"R15-33-20160304","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1182\/blood-2006-02-002477","volume":"109","author":"Ramilo","year":"2007","journal-title":"Blood"},{"key":"R16-33-20160304","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/nature03985","volume":"437","author":"Calvano","year":"2005","journal-title":"Nature"},{"key":"R17-33-20160304","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S0196-6553(99)70031-3","volume":"27","author":"","year":"1999","journal-title":"Am J Infect Control"},{"key":"R18-33-20160304","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/rccm.200405-644ST","volume":"171","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"R19-33-20160304","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1097\/01.CCM.0000055385.29232.11","volume":"31","author":"Coopersmith","year":"2003","journal-title":"Crit Care Med"},{"key":"R20-33-20160304","first-page":"623","volume":"22","author":"Vyas","year":"2007","journal-title":"Histol Histopathol"},{"key":"R21-33-20160304","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1001\/jama.287.13.1716","volume":"287","author":"Coopersmith","year":"2002","journal-title":"JAMA"},{"key":"R22-33-20160304","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.4049\/jimmunol.142.11.3884","volume":"142","author":"Sheehan","year":"1989","journal-title":"J Immunol"},{"key":"R23-33-20160304","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/01.shk.0000101668.49265.19","volume":"21","author":"Knight","year":"2004","journal-title":"Shock"},{"key":"R24-33-20160304","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/01.shk.0000145935.24344.2d","volume":"22","author":"Wells","year":"2004","journal-title":"Shock"},{"key":"R25-33-20160304","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/00000658-199810000-00008","volume":"228","author":"Magnotti","year":"1998","journal-title":"Ann Surg"},{"key":"R26-33-20160304","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"R27-33-20160304","doi-asserted-by":"crossref","first-page":"e1564","DOI":"10.1371\/journal.pone.0001564","volume":"3","author":"McDunn","year":"2008","journal-title":"PLoS ONE"},{"key":"R28-33-20160304","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1164\/rccm.200204-302OC","volume":"166","author":"Eichacker","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"R29-33-20160304","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1097\/01.CCM.0000145229.59014.6C","volume":"32","author":"Panacek","year":"2004","journal-title":"Crit Care Med"},{"key":"R30-33-20160304","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1097\/00003246-200104000-00015","volume":"29","author":"Reinhart","year":"2001","journal-title":"Crit Care Med"},{"key":"R31-33-20160304","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/00000542-200307000-00016","volume":"99","author":"Karzai","year":"2003","journal-title":"Anesthesiology"},{"key":"R32-33-20160304","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/01.shk.0000228801.56223.92","volume":"26","author":"Gomes","year":"2006","journal-title":"Shock"},{"key":"R33-33-20160304","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.femsim.2005.01.001","volume":"44","author":"Nau","year":"2005","journal-title":"FEMS Immunol Med Microbiol"},{"key":"R34-33-20160304","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/01.shk.0000054370.24363.ee","volume":"19","author":"Coopersmith","year":"2003","journal-title":"Shock"},{"key":"R35-33-20160304","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMra021333","volume":"348","author":"Hotchkiss","year":"2003","journal-title":"N Engl J Med"},{"key":"R36-33-20160304","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1128\/IAI.72.2.788-794.2004","volume":"72","author":"Branger","year":"2004","journal-title":"Infect Immun"},{"key":"R37-33-20160304","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1128\/IAI.69.1.426-434.2001","volume":"69","author":"Gingles","year":"2001","journal-title":"Infect Immun"},{"key":"R38-33-20160304","doi-asserted-by":"crossref","first-page":"L297","DOI":"10.1152\/ajplung.00138.2006","volume":"291","author":"Prince","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"R39-33-20160304","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1097\/CCM.0b013e318183f3f8","volume":"36","author":"Zhuo","year":"2008","journal-title":"Crit Care Med"}],"container-title":["Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00003246-201001000-00033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:11:04Z","timestamp":1786039864000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00003246-201001000-00033"}},"subtitle":[""],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":38,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1097\/ccm.0b013e3181b4a76b","relation":{},"ISSN":["0090-3493"],"issn-type":[{"value":"0090-3493","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}