{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:11:22Z","timestamp":1790518282184,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Critical Care Medicine"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1097\/ccm.0b013e3181b755d5","type":"journal-article","created":{"date-parts":[[2009,9,18]],"date-time":"2009-09-18T11:46:37Z","timestamp":1253274397000},"page":"2767-2774","source":"Crossref","is-referenced-by-count":15,"title":["Effect of acute inflammatory brain injury on accumulation of morphine and morphine 3- and 6-glucuronide in the human brain*"],"prefix":"10.1097","volume":"37","author":[{"given":"Derek J.","family":"Roberts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry B.","family":"Goralski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Renton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa C.","family":"Julien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Webber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lekha","family":"Sleno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich A.","family":"Volmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard I.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-14-20160304","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0031-6997(24)01320-6","volume":"49","author":"de Vries","year":"1997","journal-title":"Pharmacol Rev"},{"key":"R2-14-20160304","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s11095-007-9374-5","volume":"24","author":"Ohtsuki","year":"2007","journal-title":"Pharm Res"},{"key":"R3-14-20160304","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0092-8674(94)90212-7","volume":"77","author":"Schinkel","year":"1994","journal-title":"Cell"},{"key":"R4-14-20160304","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1172\/JCI118214","volume":"96","author":"Schinkel","year":"1995","journal-title":"J Clin Invest"},{"key":"R5-14-20160304","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/sj.bjp.0705227","volume":"139","author":"Goralski","year":"2003","journal-title":"Br J Pharmacol"},{"key":"R6-14-20160304","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1517\/17425255.4.10.1245","volume":"4","author":"Roberts","year":"2008","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"R7-14-20160304","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1023\/A:1011938112599","volume":"15","author":"Letrent","year":"1998","journal-title":"Pharm Res"},{"key":"R8-14-20160304","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1097\/00000542-200005000-00030","volume":"92","author":"Thompson","year":"2000","journal-title":"Anesthesiology"},{"key":"R9-14-20160304","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0304-3959(97)00142-5","volume":"74","author":"Faura","year":"1998","journal-title":"Pain"},{"key":"R10-14-20160304","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0006-8993(79)90849-7","volume":"174","author":"Labella","year":"1979","journal-title":"Brain Res"},{"key":"R11-14-20160304","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0024-3205(94)00552-4","volume":"54","author":"Bartlett","year":"1994","journal-title":"Life Sci"},{"key":"R12-14-20160304","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1038\/sj.bjp.0703759","volume":"131","author":"Xie","year":"2000","journal-title":"Br J Pharmacol"},{"key":"R13-14-20160304","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1038\/sj.bjp.0704406","volume":"134","author":"Bouw","year":"2001","journal-title":"Br J Pharmacol"},{"key":"R14-14-20160304","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1046\/j.1471-4159.2003.01990.x","volume":"86","author":"Bourasset","year":"2003","journal-title":"J Neurochem"},{"key":"R15-14-20160304","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1097\/00000542-200412000-00020","volume":"101","author":"Skarke","year":"2004","journal-title":"Anesthesiology"},{"key":"R16-14-20160304","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s007010050197","volume":"140","author":"Osuka","year":"1998","journal-title":"Acta Neurochir (Wien)"},{"key":"R17-14-20160304","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3171\/jns.2007.106.5.820","volume":"106","author":"Hillman","year":"2007","journal-title":"J Neurosurg"},{"key":"R18-14-20160304","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(02)00169-2","volume":"55","author":"Schinkel","year":"2003","journal-title":"Adv Drug Deliv Rev"},{"key":"R19-14-20160304","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0006-2952(03)00340-X","volume":"66","author":"Theron","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"R20-14-20160304","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1124\/mol.105.017954","volume":"69","author":"Hartz","year":"2006","journal-title":"Mol Pharmacol"},{"key":"R21-14-20160304","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1124\/mol.106.029512","volume":"71","author":"Bauer","year":"2007","journal-title":"Mol Pharmacol"},{"key":"R22-14-20160304","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/85115","volume":"4","author":"King","year":"2001","journal-title":"Nat Neurosci"},{"key":"R23-14-20160304","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1254\/jphs.FP0071287","volume":"105","author":"Hamabe","year":"2007","journal-title":"J Pharmacol Sci"},{"key":"R24-14-20160304","first-page":"592","volume":"54","author":"Meineke","year":"2002","journal-title":"Br J Clin Pharmacol"},{"key":"R25-14-20160304","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1034\/j.1399-6576.2001.045003390.x","volume":"45","author":"Bouw","year":"2001","journal-title":"Acta Anaesthesiol Scand"},{"key":"R26-14-20160304","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1046\/j.1365-2125.2003.02032.x","volume":"57","author":"Ederoth","year":"2004","journal-title":"Br J Clin Pharmacol"},{"key":"R27-14-20160304","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1111\/j.1476-5381.1996.tb15619.x","volume":"118","author":"Huwyler","year":"1996","journal-title":"Br J Pharmacol"},{"key":"R28-14-20160304","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1471-4159.2002.01177.x","volume":"83","author":"Lotsch","year":"2002","journal-title":"J Neurochem"},{"key":"R29-14-20160304","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1016\/S0024-3205(00)00569-5","volume":"66","author":"Lotsch","year":"2000","journal-title":"Life Sci"},{"key":"R30-14-20160304","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.neuroscience.2004.07.051","volume":"129","author":"Nies","year":"2004","journal-title":"Neuroscience"},{"key":"R31-14-20160304","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1124\/mol.107.035592","volume":"72","author":"van de Wetering","year":"2007","journal-title":"Mol Pharmacol"},{"key":"R32-14-20160304","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1161\/STROKEAHA.107.504498","volume":"39","author":"Welsh","year":"2008","journal-title":"Stroke"}],"container-title":["Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00003246-200910000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T07:26:11Z","timestamp":1739345171000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.lww.com\/00003246-200910000-00014"}},"subtitle":[""],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":32,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.1097\/ccm.0b013e3181b755d5","relation":{},"ISSN":["0090-3493"],"issn-type":[{"value":"0090-3493","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}