{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:23:23Z","timestamp":1763036603056},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>Acute coronary syndrome is a common cause of morbidity and mortality, both in the United States and worldwide. The goal of this review is to familiarize clinicians with recent information regarding the diagnosis and treatment of acute coronary syndrome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Data Sources:<\/jats:title>\n            <jats:p>PubMed search and review of the relevant medical literature.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Summary:<\/jats:title>\n            <jats:p>Acute coronary syndrome encompasses three clinical diagnoses: unstable angina, non-ST-segment elevation myocardial infarction), and ST-segment elevation myocardial infarction. The definition, pathophysiology, clinical presentation, diagnosis, and treatment of unstable angina\/non-ST-segment elevation myocardial infarction are reviewed here. Diagnosing unstable angina\/non-ST-segment elevation myocardial infarction is a significant challenge in critically ill patients not initially suspected of having acute coronary syndrome (i.e., noncardiac intensive care unit patients), and diagnostic and treatment strategies for these patients have not been clearly established.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Patients with acute coronary syndrome benefit from intensive medical therapy, including antianginal, antiplatelet, antithrombotic, and statin agents. Depending on their risk for future cardiovascular events as well as their risk of bleeding complications, patients may benefit from either an early invasive treatment strategy, in which routine coronary revascularization is performed, or a conservative strategy, in which revascularization is reserved for patients with recurrent or provocable cardiac ischemia.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/ccm.0b013e31821e855f","type":"journal-article","created":{"date-parts":[[2011,5,19]],"date-time":"2011-05-19T07:51:15Z","timestamp":1305791475000},"page":"2346-2353","source":"Crossref","is-referenced-by-count":17,"title":["Treatment of acute coronary syndrome: Part 1: Non-ST-segment acute coronary syndrome"],"prefix":"10.1097","volume":"39","author":[{"given":"Jeffrey C.","family":"Trost","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard 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Intensive versus moderate lipid lowering with statins after acute coronary syndromes.","volume":"350","author":"Cannon","year":"2004","journal-title":"N Engl J Med"},{"key":"R37-20-20240205","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1001\/jama.290.12.1593","article-title":"Evaluation of prolonged antithrombotic pretreatment (\u2018cooling-off\u2019 strategy) before intervention in patients with unstable coronary syndromes: A randomized controlled trial.","volume":"290","author":"Neumann","year":"2003","journal-title":"JAMA"},{"key":"R38-20-20240205","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/S0195-668X(03)00259-8","article-title":"A comparison of two invasive strategies in patients with non-ST elevation acute coronary syndromes: results of the Early or Late Intervention in unStable Angina (ELISA) pilot study. 2b\/3a upstream therapy and acute coronary syndromes.","volume":"24","author":"van't Hof","year":"2003","journal-title":"Eur Heart J"},{"key":"R39-20-20240205","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1136\/hrt.2008.154815","article-title":"OPTIMA trial. Immediate versus deferred coronary angioplasty in non-ST-segment elevation acute coronary syndromes.","volume":"95","author":"Riezebos","year":"2009","journal-title":"Heart"},{"key":"R40-20-20240205","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1056\/NEJMoa0807986","article-title":"Early versus delayed invasive intervention in acute coronary syndromes.","volume":"360","author":"Mehta","year":"2009","journal-title":"N Engl J Med"},{"key":"R41-20-20240205","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1001\/jama.2009.1267","article-title":"Immediate vs delayed intervention for acute coronary syndromes: A randomized clinical trial.","volume":"302","author":"Montalescot","year":"2009","journal-title":"JAMA"}],"container-title":["Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00003246-201110000-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T05:08:19Z","timestamp":1707109699000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00003246-201110000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/ccm.0b013e31821e855f","relation":{},"ISSN":["0090-3493"],"issn-type":[{"value":"0090-3493","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}