{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:17:59Z","timestamp":1777393079773,"version":"3.51.4"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Critical Care Medicine"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1097\/ccm.0b013e31824ea05e","type":"journal-article","created":{"date-parts":[[2012,5,5]],"date-time":"2012-05-05T15:35:37Z","timestamp":1336232137000},"page":"2168-2175","source":"Crossref","is-referenced-by-count":18,"title":["Endogenous tissue-type plasminogen activator impairs host defense during severe experimental gram-negative sepsis (melioidosis)*"],"prefix":"10.1097","volume":"40","author":[{"given":"Liesbeth M.","family":"Kager","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Joost","family":"Wiersinga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joris J. T. H.","family":"Roelofs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joost C. M.","family":"Meijers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Levi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis","family":"van\u2019t Veer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"van der Poll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-21-20160304","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/CCM.0b013e3181c98d21","volume":"38","author":"Levi","year":"2010","journal-title":"Crit Care Med"},{"key":"R3-21-20160304","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1183\/09031936.04.00140703","volume":"24","author":"Choi","year":"2004","journal-title":"Eur Respir J"},{"key":"R5-21-20160304","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1136\/thorax.2003.013888","volume":"59","author":"Schultz","year":"2004","journal-title":"Thorax"},{"key":"R6-21-20160304","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/01.shk.0000144422.32647.b6","volume":"23","author":"Iba","year":"2005","journal-title":"Shock"},{"key":"R7-21-20160304","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1055\/s-0037-1616084","volume":"86","author":"Raaphorst","year":"2001","journal-title":"Thromb Haemost"},{"key":"R8-21-20160304","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1160\/TH07-02-0117","volume":"98","author":"Bergmann","year":"2007","journal-title":"Thromb Haemost"},{"key":"R9-21-20160304","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.4049\/jimmunol.177.2.1189","volume":"177","author":"Renckens","year":"2006","journal-title":"J Immunol"},{"key":"R10-21-20160304","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1538-7836.2008.02892.x","volume":"6","author":"Renckens","year":"2008","journal-title":"J Thromb Haemost"},{"key":"R11-21-20160304","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrmicro1385","volume":"4","author":"Wiersinga","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"R12-21-20160304","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1128\/CMR.18.2.383-416.2005","volume":"18","author":"Cheng","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"R13-21-20160304","doi-asserted-by":"crossref","first-page":"e900","DOI":"10.1371\/journal.pntd.0000900","volume":"4","author":"Currie","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"R14-21-20160304","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1538-7836.2007.02796.x","volume":"6","author":"Wiersinga","year":"2008","journal-title":"J Thromb Haemost"},{"key":"R15-21-20160304","doi-asserted-by":"crossref","first-page":"e248","DOI":"10.1371\/journal.pmed.0040248","volume":"4","author":"Wiersinga","year":"2007","journal-title":"PLoS Med"},{"key":"R16-21-20160304","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1086\/592220","volume":"198","author":"Wiersinga","year":"2008","journal-title":"J Infect Dis"},{"key":"R17-21-20160304","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1111\/j.1538-7836.2011.04473.x","volume":"9","author":"Kager","year":"2011","journal-title":"J Thromb Haemost"},{"key":"R18-21-20160304","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.4049\/jimmunol.168.7.3507","volume":"168","author":"Rijneveld","year":"2002","journal-title":"J Immunol"},{"key":"R19-21-20160304","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1182\/blood-2004-12-4623","volume":"106","author":"Weijer","year":"2005","journal-title":"Blood"},{"key":"R20-21-20160304","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1128\/IAI.00080-07","volume":"75","author":"Wiersinga","year":"2007","journal-title":"Infect Immun"},{"key":"R21-21-20160304","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/cid\/cir808","volume":"54","author":"Meumann","year":"2012","journal-title":"Clin Infect Dis"},{"key":"R22-21-20160304","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/CCM.0b013e31819584f9","volume":"37","author":"Hoogerwerf","year":"2009","journal-title":"Crit Care Med"},{"key":"R23-21-20160304","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/ndt\/gfn562","volume":"24","author":"Roelofs","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"R24-21-20160304","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1182\/blood.V78.12.3114.3114","volume":"78","author":"Collen","year":"1991","journal-title":"Blood"},{"key":"R25-21-20160304","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tins.2008.09.006","volume":"32","author":"Yepes","year":"2009","journal-title":"Trends Neurosci"},{"key":"R26-21-20160304","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1128\/IAI.00832-08","volume":"77","author":"Craig","year":"2009","journal-title":"Infect Immun"},{"key":"R27-21-20160304","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1182\/blood-2008-07-170506","volume":"113","author":"Sun","year":"2009","journal-title":"Blood"},{"key":"R28-21-20160304","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1086\/315155","volume":"180","author":"Lauw","year":"1999","journal-title":"J Infect Dis"},{"key":"R29-21-20160304","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1086\/315271","volume":"181","author":"Simpson","year":"2000","journal-title":"J Infect Dis"},{"key":"R30-21-20160304","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1128\/IAI.67.7.3593-3600.1999","volume":"67","author":"Santanirand","year":"1999","journal-title":"Infect Immun"}],"container-title":["Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00003246-201207000-00021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T06:28:44Z","timestamp":1713940124000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.lww.com\/00003246-201207000-00021"}},"subtitle":[""],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":28,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.1097\/ccm.0b013e31824ea05e","relation":{},"ISSN":["0090-3493"],"issn-type":[{"value":"0090-3493","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}