{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:11:38Z","timestamp":1786119098153,"version":"build-2736575974"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1097\/cco.0b013e328319ea7b","type":"journal-article","created":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T03:13:46Z","timestamp":1229051626000},"page":"29-33","source":"Crossref","is-referenced-by-count":36,"title":["Molecular genetics of gastroenteropancreatic neuroendocrine tumors"],"prefix":"10.1097","volume":"21","author":[{"given":"Lee F","family":"Starker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Carling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20210128","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1470-2045(07)70410-2","article-title":"Gastroenteropancreatic neuroendocrine tumours","volume":"9","author":"Modlin","year":"2008","journal-title":"Lancet Oncol"},{"key":"R2-7-20210128","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.bpg.2005.06.002","article-title":"Endocrine tumours of the pancreas","volume":"19","author":"Oberg","year":"2005","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"R3-7-20210128","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/01.cco.0000148567.29850.31","article-title":"Multiple endocrine neoplasia syndrome: genetic basis for clinical management","volume":"17","author":"Carling","year":"2005","journal-title":"Curr Opin Oncol"},{"key":"R4-7-20210128","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1210\/jcem.86.12.8070","article-title":"Guidelines for diagnosis and therapy of MEN type 1 and type 2","volume":"86","author":"Brandi","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"R5-7-20210128","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.276.5311.404","article-title":"Positional cloning of the gene for multiple endocrine neoplasia type 1","volume":"276","author":"Chandrasekharappa","year":"1997","journal-title":"Science"},{"key":"R6-7-20210128","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/hmg\/6.7.1177","article-title":"Identification of the multiple endocrine neoplasia type 1 (MEN1) gene.","volume":"6","author":"The European","year":"1997","journal-title":"Hum Mol Genet"},{"key":"R7-7-20210128","first-page":"2960","article-title":"Parathyroid MEN1 gene mutations in relation to clinical characteristics of nonfamilial primary hyperparathyroidism","volume":"83","author":"Carling","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"R8-7-20210128","first-page":"2627","article-title":"Alterations of the MEN1 gene in sporadic parathyroid tumors","volume":"83","author":"Farnebo","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"R9-7-20210128","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/ng0897-375","article-title":"Somatic mutations of the MEN1 gene in parathyroid tumours","volume":"16","author":"Heppner","year":"1997","journal-title":"Nat Genet"},{"key":"R10-7-20210128","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/(SICI)1098-2264(199911)26:3<258::AID-GCC11>3.0.CO;2-2","article-title":"Genetic alterations on 3p, 11q13, and 18q in nonfamilial and MEN 1-associated pancreatic endocrine tumors","volume":"26","author":"Hessman","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"key":"R11-7-20210128","first-page":"377","article-title":"Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas","volume":"58","author":"Hessman","year":"1998","journal-title":"Cancer Res"},{"key":"R12-7-20210128","first-page":"1355","article-title":"Multiple allelic deletions and intratumoral genetic heterogeneity in men1 pancreatic tumors","volume":"86","author":"Hessman","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"R13-7-20210128","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1196\/annals.1294.020","article-title":"Molecular pathology of the MEN1 gene","volume":"1014","author":"Agarwal","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"R14-7-20210128","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0092-8674(00)80967-8","article-title":"Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription","volume":"96","author":"Agarwal","year":"1999","journal-title":"Cell"},{"key":"R15-7-20210128","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1093\/hmg\/ddh271","article-title":"Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1","volume":"13","author":"Busygina","year":"2004","journal-title":"Hum Mol Genet"},{"key":"R16-7-20210128","first-page":"4204","article-title":"Menin associates with FANCD2, a protein involved in repair of DNA damage","volume":"63","author":"Jin","year":"2003","journal-title":"Cancer Res"},{"key":"R17-7-20210128","first-page":"6135","article-title":"Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex","volume":"63","author":"Kim","year":"2003","journal-title":"Cancer Res"},{"key":"R18-7-20210128","doi-asserted-by":"crossref","first-page":"6791","DOI":"10.1158\/0008-5472.CAN-04-0724","article-title":"Functional interaction between tumor suppressor menin and activator of S-phase kinase","volume":"64","author":"Schnepp","year":"2004","journal-title":"Cancer Res"},{"key":"R19-7-20210128","doi-asserted-by":"crossref","first-page":"10685","DOI":"10.1074\/jbc.M308073200","article-title":"Menin induces apoptosis in murine embryonic fibroblasts","volume":"279","author":"Schnepp","year":"2004","journal-title":"J Biol Chem"},{"key":"R20-7-20210128","doi-asserted-by":"crossref","first-page":"40267","DOI":"10.1074\/jbc.M401312200","article-title":"Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2","volume":"279","author":"Sowa","year":"2004","journal-title":"J Biol Chem"},{"key":"R21-7-20210128","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1158\/0008-5472.CAN-03-3334","article-title":"Menin inactivation leads to loss of transforming growth factor beta inhibition of parathyroid cell proliferation and parathyroid hormone secretion","volume":"64","author":"Sowa","year":"2004","journal-title":"Cancer Res"},{"key":"R22-7-20210128","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1210\/jc.2003-031228","article-title":"Transfection of the multiple endocrine neoplasia type 1 gene to a human endocrine pancreatic tumor cell line inhibits cell growth and affects expression of JunD, delta-like protein 1\/preadipocyte factor-1, proliferating cell nuclear antigen, and QM\/Jif-1","volume":"89","author":"Stalberg","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"R23-7-20210128","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S1097-2765(04)00081-4","article-title":"Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus","volume":"13","author":"Hughes","year":"2004","journal-title":"Mol Cell"},{"key":"R24-7-20210128","doi-asserted-by":"crossref","first-page":"49045","DOI":"10.1074\/jbc.M409358200","article-title":"Direct binding of DNA by tumor suppressor menin","volume":"19","author":"La","year":"2004","journal-title":"J Biol Chem"},{"key":"R25-7-20210128","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ccr.2008.05.003","article-title":"Menin critically links MLL proteins with LEDGF on cancer-associated target genes","volume":"14","author":"Yokoyama","year":"2008","journal-title":"Cancer Cell"},{"key":"R26-7-20210128","doi-asserted-by":"crossref","first-page":"6569","DOI":"10.1128\/MCB.24.15.6569-6580.2004","article-title":"Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway","volume":"24","author":"Yaguchi","year":"2004","journal-title":"Mol Cell Biol"},{"key":"R27-7-20210128","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1210\/me.2003-0154","article-title":"Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1","volume":"17","author":"Bertolino","year":"2003","journal-title":"Mol Endocrinol"},{"key":"R28-7-20210128","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1128\/MCB.24.8.3125-3131.2004","article-title":"Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues","volume":"24","author":"Biondi","year":"2004","journal-title":"Mol Cell Biol"},{"key":"R29-7-20210128","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.1128\/MCB.23.17.6075-6085.2003","article-title":"Of mice and MEN1: insulinomas in a conditional mouse knockout","volume":"23","author":"Crabtree","year":"2003","journal-title":"Mol Cell Biol"},{"key":"R30-7-20210128","doi-asserted-by":"crossref","first-page":"7039","DOI":"10.1158\/0008-5472.CAN-04-1648","article-title":"Pancreatic insulinomas in multiple endocrine neoplasia, type I knockout mice can develop in the absence of chromosome instability or microsatellite instability","volume":"64","author":"Scacheri","year":"2004","journal-title":"Cancer Res"},{"key":"R31-7-20210128","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1210\/jc.2006-1944","article-title":"Multiple endocrine neoplasia type 1 (MEN1): loss of one MEN1 allele in tumors and monohormonal endocrine cell clusters but not in islet hyperplasia of the pancreas","volume":"92","author":"Perren","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"R32-7-20210128","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/S0140-6736(03)13643-4","article-title":"von Hippel-Lindau disease","volume":"361","author":"Lonser","year":"2003","journal-title":"Lancet"},{"key":"R33-7-20210128","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/MPA.0b013e31815f394a","article-title":"Endocrine pancreatic tumors in von Hippel-Lindau disease: clinical, histological, and genetic features","volume":"37","author":"Corcos","year":"2008","journal-title":"Pancreas"},{"key":"R34-7-20210128","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.8493574","article-title":"Identification of the von Hippel-Lindau disease tumor suppressor gene","volume":"260","author":"Latif","year":"1993","journal-title":"Science"},{"key":"R35-7-20210128","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrc885","article-title":"Molecular basis of the VHL hereditary cancer syndrome","volume":"2","author":"Kaelin","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"R36-7-20210128","first-page":"1952","article-title":"High frequency loss of heterozygosity in von Hippel-Lindau (VHL)-associated and sporadic pancreatic islet cell tumors: evidence for a stepwise mechanism for malignant conversion in VHL tumorigenesis","volume":"62","author":"Lott","year":"2002","journal-title":"Cancer Res"},{"key":"R37-7-20210128","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4158\/EP.8.2.109","article-title":"Insulinoma in a patient with tuberous sclerosis: is there an association?","volume":"8","author":"Eledrisi","year":"2002","journal-title":"Endocr Pract"},{"key":"R38-7-20210128","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1677\/ERC-07-0157","article-title":"Somatostatin-producing neuroendocrine tumors of the duodenum and pancreas: incidence, types, biological behavior, association with inherited syndromes, and functional activity","volume":"15","author":"Garbrecht","year":"2008","journal-title":"Endocr Relat Cancer"},{"key":"R39-7-20210128","doi-asserted-by":"crossref","first-page":"8573","DOI":"10.1073\/pnas.0503224102","article-title":"The NF1 tumor suppressor critically regulates TSC2 and mTOR","volume":"102","author":"Johannessen","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R40-7-20210128","doi-asserted-by":"crossref","first-page":"9250","DOI":"10.1073\/pnas.0803047105","article-title":"Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner","volume":"105","author":"Rachdi","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R41-7-20210128","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1677\/ERC-07-0194","article-title":"Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis","volume":"15","author":"Duerr","year":"2008","journal-title":"Endocr Relat Cancer"},{"key":"R42-7-20210128","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1365-2265.2006.02694.x","article-title":"Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours","volume":"66","author":"Lindberg","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"R43-7-20210128","first-page":"4417","article-title":"Mutation of the MENIN gene in sporadic pancreatic endocrine tumors","volume":"58","author":"Wang","year":"1998","journal-title":"Cancer Res"},{"key":"R44-7-20210128","first-page":"4682","article-title":"Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas","volume":"57","author":"Zhuang","year":"1997","journal-title":"Cancer Res"},{"key":"R45-7-20210128","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1172\/JCI119547","article-title":"A novel pancreatic endocrine tumor suppressor gene locus on chromosome 3p with clinical prognostic implications","volume":"100","author":"Chung","year":"1997","journal-title":"J Clin Invest"},{"key":"R46-7-20210128","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1038\/sj.onc.1202585","article-title":"Mutations of the DPC4\/Smad4 gene in neuroendocrine pancreatic tumors","volume":"18","author":"Bartsch","year":"1999","journal-title":"Oncogene"},{"key":"R47-7-20210128","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1572-0241.2007.01777.x","article-title":"Molecular genetics of gastroenteropancreatic neuroendocrine tumors","volume":"103","author":"Toumpanakis","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"R48-7-20210128","first-page":"5988","article-title":"Global expression analysis of well differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays","volume":"9","author":"Maitra","year":"2003","journal-title":"Clin Cancer Res"},{"key":"R49-7-20210128","doi-asserted-by":"crossref","first-page":"6152","DOI":"10.1158\/1078-0432.CCR-04-0285","article-title":"Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well differentiated pancreatic endocrine neoplasms","volume":"10","author":"Hansel","year":"2004","journal-title":"Clin Cancer Res"},{"key":"R50-7-20210128","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/gcc.20561","article-title":"High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss","volume":"47","author":"Kulke","year":"2008","journal-title":"Genes Chromosomes Cancer"},{"key":"R51-7-20210128","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/S0002-9440(10)64136-3","article-title":"Comparative genomic hybridization identifies loss of 18q22-qter as an early and specific event in tumorigenesis of midgut carcinoids","volume":"158","author":"Kytola","year":"2001","journal-title":"Am J Pathol"},{"key":"R52-7-20210128","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/ijc.1276","article-title":"Chromosome 18 deletions are common events in classical midgut carcinoid tumors","volume":"92","author":"Lollgen","year":"2001","journal-title":"Int J Cancer"},{"key":"R53-7-20210128","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/(SICI)1098-2264(199805)22:1<50::AID-GCC7>3.0.CO;2-6","article-title":"Comparative genomic hybridization analysis of sporadic neuroendocrine tumors of the digestive system","volume":"22","author":"Terris","year":"1998","journal-title":"Genes Chromosomes Cancer"},{"key":"R54-7-20210128","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/modpathol.3800389","article-title":"Comparison of genetic alterations in neuroendocrine tumors: frequent loss of chromosome 18 in ileal carcinoid tumors","volume":"18","author":"Wang","year":"2005","journal-title":"Mod Pathol"},{"key":"R55-7-20210128","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0002-9440(10)64780-3","article-title":"Genomic alterations in well differentiated gastrointestinal and bronchial neuroendocrine tumors (carcinoids): marked differences indicating diversity in molecular pathogenesis","volume":"157","author":"Zhao","year":"2000","journal-title":"Am J Pathol"},{"key":"R56-7-20210128","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1002\/cncr.21451","article-title":"The molecular genetics of gastroenteropancreatic neuroendocrine tumors","volume":"104","author":"Zikusoka","year":"2005","journal-title":"Cancer"},{"key":"R57-7-20210128","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/CCO.0b013e3282f31108","article-title":"Systematic analyses of the cancer genome: lessons learned from sequencing most of the annotated human protein-coding genes","volume":"20","author":"Sjoblom","year":"2008","journal-title":"Curr Opin Oncol"},{"key":"R58-7-20210128","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.1133427","article-title":"The consensus coding sequences of human breast and colorectal cancers","volume":"314","author":"Sjoblom","year":"2006","journal-title":"Science"}],"container-title":["Current Opinion in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/CCO.0b013e328319ea7b","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:30:17Z","timestamp":1786037417000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001622-200901000-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/cco.0b013e328319ea7b","relation":{},"ISSN":["1040-8746"],"issn-type":[{"value":"1040-8746","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}