{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:40:32Z","timestamp":1776847232502,"version":"3.51.2"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      The aim of this paper was to examine the distribution of fecal hemoglobin (f-Hb) concentration in a Spanish colorectal cancer screening population according to sociodemographic characteristics and analyze whether f-Hb was associated with clinical outcomes (type of lesion and its location). From September 2009 to November 2012, we sent 77\u2009744 invitations to individuals aged 50\u201369 years to provide one sample of feces. f-Hb was measured on samples from 27\u2009606 screenees (35.5%). Colonoscopy findings and pathology data were collected on the 1406 screenees with f-Hb greater than 100\u2009ng\u2009Hb\/ml (20\u2009mg\u2009Hb\/g feces). The Mann\u2013Whitney\n                      <jats:italic toggle=\"yes\">U<\/jats:italic>\n                      -test and the Kruskal\u2013Wallis test were used to compare f-Hb (median) according to sociodemographic variables, clinical outcomes, and histological features of adenomas. f-Hb from greater than 100\u2009ng\u2009Hb\/ml was categorized into quartiles. Regression models were used to determine whether f-Hb was a risk predictor of colorectal lesions. f-Hb was associated directly with the severity of the colorectal lesions. An overlap between individuals with a negative colonoscopy and those with a low-risk adenoma was observed. High-grade dysplasia, villous histology, distal location, and increasing size were all features associated with an increased f-Hb level. f-Hb could be used in individual risk assessment to determine surveillance strategies for colorectal cancer screening.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/cej.0000000000000090","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T22:41:25Z","timestamp":1415140885000},"page":"321-327","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["Fecal hemoglobin concentration as a measure of risk to tailor colorectal cancer screening"],"prefix":"10.1097","volume":"24","author":[{"given":"Montse","family":"Garcia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00faria","family":"Mil\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Binefa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ll\u00facia","family":"Benito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00faria","family":"Gonzalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-7-20251125","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1053\/j.gastro.2012.01.015","article-title":"Comparing fecal immunochemical tests: improved standardization is needed","volume":"142","author":"Allison","year":"2012","journal-title":"Gastroenterology"},{"key":"R3-7-20251125","doi-asserted-by":"crossref","first-page":"iii111","DOI":"10.1093\/annonc\/mdq099","article-title":"Priorities for cancer control in Spain","volume":"21","author":"Borr\u00e0s","year":"2010","journal-title":"Ann Oncol"},{"key":"R4-7-20251125","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ejca.2013.09.015","article-title":"Sorting out measures and definitions of screening participation to improve comparability: the example of colorectal cancer","volume":"50","author":"Bulliard","year":"2014","journal-title":"Eur J Cancer"},{"key":"R6-7-20251125","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S1470-2045(11)70101-2","article-title":"Baseline fecal occult blood concentration as a predictor of incident colorectal neoplasia: longitudinal follow-up of a Taiwanese population-based colorectal cancer screening cohort","volume":"12","author":"Chen","year":"2011","journal-title":"Lancet Oncol"},{"key":"R7-7-20251125","doi-asserted-by":"crossref","first-page":"e003740","DOI":"10.1136\/bmjopen-2013-003740","article-title":"Impact of faecal haemoglobin concentration on colorectal cancer mortality and all-cause death","volume":"3","author":"Chen","year":"2013","journal-title":"BMJ Open"},{"key":"R8-7-20251125","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/sj.bjc.6603534","article-title":"Association of FOBT-assessed faecal Hb content with colonic lesions detected in the Florence screening programme","volume":"96","author":"Ciatto","year":"2007","journal-title":"Br J Cancer"},{"key":"R9-7-20251125","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cgh.2012.02.030","article-title":"High rate of advanced adenoma detection in 4 rounds of colorectal cancer screening with the fecal immunochemical test","volume":"10","author":"Crotta","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R10-7-20251125","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1136\/jclinpath-2013-201445","article-title":"Faecal haemoglobin concentration is related to severity of colorectal neoplasia","volume":"66","author":"Digby","year":"2013","journal-title":"J Clin Pathol"},{"key":"R11-7-20251125","doi-asserted-by":"crossref","first-page":"e1001352","DOI":"10.1371\/journal.pmed.1001352","article-title":"Effect of flexible sigmoidoscopy-based screening on incidence and mortality of colorectal cancer: a systematic review and meta-analysis of randomized controlled trials","volume":"9","author":"Elmunzer","year":"2012","journal-title":"PLoS Med"},{"key":"R12-7-20251125","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1258\/acb.2012.012065","article-title":"A future for faecal haemoglobin measurements in the medical laboratory","volume":"49","author":"Fraser","year":"2012","journal-title":"Ann Clin Biochem"},{"key":"R13-7-20251125","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1136\/gut.2008.153494","article-title":"Automated immunochemical quantitation of haemoglobin in faeces collected on cards for screening for colorectal cancer","volume":"57","author":"Fraser","year":"2008","journal-title":"Gut"},{"key":"R14-7-20251125","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/jnci\/djs190","article-title":"A proposal to standardize reporting units for fecal immunochemical tests for hemoglobin","volume":"104","author":"Fraser","year":"2012","journal-title":"J Natl Cancer Inst"},{"key":"R15-7-20251125","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1515\/cclm-2013-0408","article-title":"Making colorectal cancer screening FITTER for purpose with quantitative faecal immunochemical tests for haemoglobin (FIT)","volume":"51","author":"Fraser","year":"2013","journal-title":"Clin Chem Lab Med"},{"key":"R16-7-20251125","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1590\/S1135-57272011000600008","article-title":"Evaluating colorectal cancer screening strategies (immunological test vs biochemical test) in Catalonia, Spain 2008\u20132010","volume":"85","author":"Garc\u00eda Mart\u00ednez","year":"2011","journal-title":"Rev Esp Salud Publica"},{"key":"R17-7-20251125","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00008469-200402000-00004","article-title":"Colorectal cancer screening programme by faecal occult blood test in Tuscany: first round results","volume":"13","author":"Grazzini","year":"2004","journal-title":"Eur J Cancer Prev"},{"key":"R18-7-20251125","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1136\/gut.2009.200873","article-title":"Influence of seasonal variations in ambient temperatures on performance of immunochemical faecal occult blood test for colorectal cancer screening: observational study from the Florence district","volume":"59","author":"Grazzini","year":"2010","journal-title":"Gut"},{"key":"R19-7-20251125","first-page":"SE65","article-title":"European guidelines for quality assurance in colorectal cancer screening and diagnosis. First edition \u2013 faecal occult blood testing","volume":"44","author":"Halloran","year":"2012","journal-title":"Endoscopy"},{"key":"R20-7-20251125","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1111\/j.1572-0241.2008.01875.x","article-title":"Cochrane systematic review of colorectal cancer screening using the fecal occult blood test (Hemoccult): an update","volume":"103","author":"Hewitson","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"R21-7-20251125","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/gut.2009.177089","article-title":"Screening for colorectal cancer: randomised trial comparing guaiac-based and immunochemical faecal occult blood testing and flexible sigmoidoscopy","volume":"59","author":"Hol","year":"2010","journal-title":"Gut"},{"key":"R22-7-20251125","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/S0140-6736(13)62649-5","article-title":"Erosion of universal health coverage in Spain","volume":"382","author":"Legido-Quigley","year":"2013","journal-title":"Lancet"},{"key":"R23-7-20251125","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.canep.2013.07.008","article-title":"Colorectal cancer screening by guaiac faecal occult blood test in France: evaluation of the programme two years after launching","volume":"37","author":"Leuraud","year":"2013","journal-title":"Cancer Epidemiol"},{"key":"R24-7-20251125","doi-asserted-by":"crossref","first-page":"244","DOI":"10.7326\/0003-4819-146-4-200702200-00003","article-title":"A quantitative immunochemical fecal occult blood test for colorectal neoplasia","volume":"146","author":"Levi","year":"2007","journal-title":"Ann Intern Med"},{"key":"R25-7-20251125","doi-asserted-by":"crossref","first-page":"8366","DOI":"10.3748\/wjg.v19.i45.8366","article-title":"Application of quantitative estimates of fecal hemoglobin concentration for risk prediction of colorectal neoplasia","volume":"19","author":"Liao","year":"2013","journal-title":"World J Gastroenterol"},{"key":"R26-7-20251125","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1053\/j.gastro.2012.06.001","article-title":"Guidelines for colonoscopy surveillance after screening and polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer","volume":"143","author":"Lieberman","year":"2012","journal-title":"Gastroenterology"},{"key":"R27-7-20251125","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1258\/jms.2010.010036","article-title":"Coverage and performance of colorectal cancer screening with the faecal occult blood test in Finland","volume":"18","author":"Malila","year":"2011","journal-title":"J Med Screen"},{"key":"R28-7-20251125","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.ejca.2012.02.060","article-title":"Cancer screening and health system resilience: keys to protecting and bolstering preventive services during a financial crisis","volume":"48","author":"Martin-Moreno","year":"2012","journal-title":"Eur J Cancer"},{"key":"R29-7-20251125","first-page":"935","article-title":"Faecal haemoglobin concentrations by gender and age: implications for population-based screening for colorectal cancer","volume":"50","author":"McDonald","year":"2011","journal-title":"Clin Chem Lab Med"},{"key":"R30-7-20251125","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1097\/MEG.0b013e32834a2882","article-title":"Diagnostic performance of quantitative fecal immunochemical test and multivariate prediction model for colorectal neoplasms in asymptomatic individuals","volume":"23","author":"Omata","year":"2011","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R31-7-20251125","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1258\/096914107781261936","article-title":"Lessons learnt from a population-based pilot programme for colorectal cancer screening in Catalonia (Spain)","volume":"14","author":"Peris","year":"2007","journal-title":"J Med Screen"},{"key":"R33-7-20251125","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.cgh.2012.12.004","article-title":"Serrated colon polyps as precursors to colorectal cancer","volume":"11","author":"Sweetser","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R35-7-20251125","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1053\/j.gastro.2008.03.040","article-title":"Random comparison of guaiac and immunochemical fecal occult blood tests for colorectal cancer in a screening population","volume":"135","author":"van Rossum","year":"2008","journal-title":"Gastroenterology"},{"key":"R36-7-20251125","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/ije\/dyr008","article-title":"Inequalities in participation in an organized national colorectal cancer screening programme: results from the first 2.6 million invitations in England","volume":"40","author":"von Wagner","year":"2011","journal-title":"Int J Epidemiol"},{"key":"R37-7-20251125","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/ijc.28748","article-title":"A new insight into fecal hemoglobin concentration-dependent predictor for colorectal neoplasia","volume":"135","author":"Yen","year":"2014","journal-title":"Int J Cancer"}],"container-title":["European Journal of Cancer Prevention"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00008469-201507000-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T18:00:30Z","timestamp":1764093630000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00008469-201507000-00007"}},"subtitle":["are we there yet?"],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1097\/cej.0000000000000090","relation":{},"ISSN":["0959-8278"],"issn-type":[{"value":"0959-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}