{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:23:34Z","timestamp":1790727814486,"version":"4.1.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Although high-risk (HR) human papilloma virus (HPV) infection is the primary causative factor for cervical squamous intraepithelial lesions and invasive cervical cancer, the epidemiology of potentially HR (pHR) and low-risk HPV still remains to be elucidated in HIV-infected women. In addition, the synergistic potential of the multiplicity of HPV infections harboured renders it difficult to model the impact of vaccines. This cross-sectional analysis of HIV-infected women explores the epidemiology of abnormal cytology, thereby profiling and pairing pHR\/HR HPV genotypes. This cross-sectional analysis reports the findings of 593 HIV-infected women, who underwent a cytological examination and HPV genotyping. A logistic regression model was fitted to adjust for age and coinfection with pHR\/HR HPV genotypes. In the 143 women with abnormal cytology, a multiple pHR\/HR HPV genotype prevalence of 64.1% [95% confidence interval (CI): 44.6\u201357.6%] was observed. A combined prevalence of HPV 16 and HPV 18 of 29.6% (95% CI: 22.2\u201337.8%) was found. HPV 6 and HPV 66 were found in two cases of low-grade squamous intraepithelial lesions as stand-alone genotypes and HPV 53 in a high-grade squamous intraepithelial lesion case. Pairing involving HPV 31 with HPV 16 and HPV 58 was found in high-grade squamous intraepithelial lesion cases. Significant associations were observed between abnormal cytology, multiple HPV, HPV 39 and HPV 53 [adjusted odds ratio (aOR): 2.02; <jats:italic toggle=\"yes\">P<\/jats:italic>=0.01; 95% CI: 1.2\u20133.5; aOR: 3.8; <jats:italic toggle=\"yes\">P<\/jats:italic>=0.01; 95% CI: 1.4\u201310.7; and aOR: 0.5; <jats:italic toggle=\"yes\">P<\/jats:italic>=0.03; 95% CI: 0.2\u20130.9, respectively]. Coinfection with pHR\/HR HPV genotypes HPV 39 and 53 was significantly associated with abnormal cytology. Research into the imputed role of HPV 31 in pairings, low-risk and pHR HPV genotypes in HIV-infected women is warranted.<\/jats:p>","DOI":"10.1097\/cej.0000000000000271","type":"journal-article","created":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T11:25:24Z","timestamp":1467631524000},"page":"46-53","source":"Crossref","is-referenced-by-count":7,"title":["Human papilloma virus infection in HIV-infected women in Belgium: implications for prophylactic vaccines within this subpopulation"],"prefix":"10.1097","volume":"27","author":[{"given":"Sonia","family":"Menon","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, International Centre for Reproductive Health, Ghent University, Ghent"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Rossi","sequence":"additional","affiliation":[{"name":"AMBIOR (Applied Molecular Biology Research Group)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Benoy","sequence":"additional","affiliation":[{"name":"AMBIOR (Applied Molecular Biology Research Group)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean P.","family":"Bogers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, International Centre for Reproductive Health, Ghent University, Ghent"},{"name":"National Reference Centre for HPV, Brussels, Belgium; Laboratory of Molecular Pathology, AML, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davy","family":"van den Broeck","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, International Centre for Reproductive Health, Ghent University, Ghent"},{"name":"National Reference Centre for HPV, Brussels, Belgium; Laboratory of Molecular Pathology, AML, Antwerp, 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