{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:26:23Z","timestamp":1774265183819,"version":"3.50.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>To investigate the association of family history of malignant tumors with clinicopathological characteristics of colorectal cancer, and its effects on prognosis. We conducted a retrospective review of pathological and follow-up data of patients with colorectal cancer treated in our hospital from January 2010 to December 2015. Of 870 patients undergoing surgery, 737 received follow-up (84.7%). Among them, 192 (26.1%) were family history of malignant neoplasm-positive [MN-FH (+)] and 545 (73.9%) were family history of malignant neoplasm-negative [MN-FH (\u2013)]. MN-FH (+) patients had earlier disease onset, smaller tumor diameter, lower rate of lymph node metastasis, and lower depth of invasion. There were significant differences in BMI between the groups (<jats:italic toggle=\"yes\">P<\/jats:italic>&lt;0.05) but no differences in sex or tumor differentiation grade (<jats:italic toggle=\"yes\">P<\/jats:italic>&gt;0.05). Rates of Her-2 and p53 protein expression in MN-FH (+) patients were 34.3 and 40.5%, respectively, compared with 22.2 and 26.3% in MN-FH (\u2013) patients. In stage 3, significantly higher Her-2 and p53 protein expression rates were observed in MN-FH (+) than in MN-FH (\u2013) patients. Fluorescence in-situ hybridization showed significantly higher Her-2 expression in MN-FH (+) than in MN-FH (\u2013) patients. The 3 and 5-year overall survival, disease-free survival, and progression-free survival were significantly lower in MN-FH (+) than in MN-FH (\u2212) patients (<jats:italic toggle=\"yes\">P<\/jats:italic>&lt;0.05). MN-FH (+) patients with colorectal cancer had earlier disease onset and smaller tumor area, lower invasion depth, a lower rate of lymph node metastasis, and earlier TNM tumor stage at diagnosis than MN-FH (\u2013) patients. BMI value distribution significantly differed between groups. However, long-term prognosis was worse for MN-FH (+) than MN-FH (\u2013) patients, suggesting that internal pathogenic genes play a more crucial role than external environmental factors in prognosis. Family history of tumors could be an independent prognostic factor for colon cancer.<\/jats:p>","DOI":"10.1097\/cej.0000000000000482","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T04:29:07Z","timestamp":1559190547000},"page":"258-267","source":"Crossref","is-referenced-by-count":6,"title":["Association of family history of tumors with clinicopathological characteristics and prognosis of colorectal cancer"],"prefix":"10.1097","volume":"28","author":[{"given":"Tao","family":"Shan","sequence":"first","affiliation":[{"name":"Department of General Surgery, The Second Affiliated Hospital of Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Affiliated Hospital of Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Affiliated Hospital of Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanrun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Policy and Administration"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiancang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Affiliated Hospital of Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Affiliated Hospital of Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xijuan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of General Surgery, First Affiliated Hospital of Medical College, Xi\u2019an Jiaotong University, Xi\u2019an"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Central Hospital of Zibo, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2019an","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Affiliated Hospital of Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230902","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/CEJ.0000000000000361","article-title":"Active lifestyle patterns reduce the risk of colorectal cancer in the Mecca region, Saudi Arabia: a case\u2013control study","volume":"27","author":"Alazzeh","year":"2018","journal-title":"Eur J Cancer Prev"},{"key":"R2-20230902","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.clcc.2016.02.008","article-title":"Colorectal cancer: epidemiology, disease mechanisms and interventions to reduce onset and mortality","volume":"15","author":"Aran","year":"2016","journal-title":"Clin Colorectal Cancer"},{"key":"R3-20230902","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.prp.2013.08.007","article-title":"Lifestyle and family history influence cancer prognosis in Brazilian individuals","volume":"209","author":"Araujo","year":"2013","journal-title":"Pathol Res Pract"},{"key":"R4-20230902","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","article-title":"Global patterns and trends in colorectal cancer incidence and mortality","volume":"66","author":"Arnold","year":"2017","journal-title":"Gut"},{"key":"R5-20230902","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/cncr.23294","article-title":"Family history and survival after colorectal cancer diagnosis","volume":"112","author":"Bass","year":"2008","journal-title":"Cancer"},{"key":"R6-20230902","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1001\/jama.299.21.2515","article-title":"Association of family history with cancer recurrence and survival among patients with stage III colon cancer","volume":"299","author":"Chan","year":"2008","journal-title":"JAMA"},{"key":"R7-20230902","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/oxfordjournals.jjco.a039659","article-title":"Clinical and pathological analyses of patients with a family history of colorectal cancer. 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