{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:27:50Z","timestamp":1790908070738,"version":"4.1.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                           <jats:italic toggle=\"yes\">Cryptosporidium<\/jats:italic> spp. is an opportunistic protozoan parasite that primarily affects immunocompromised individuals, including those with colorectal cancer (CRC). This study investigates the prevalence and clinical significance of <jats:italic toggle=\"yes\">Cryptosporidium<\/jats:italic> spp. in CRC patients, including both the gastrointestinal and respiratory systems. A total of 108 CRC patients and 102 healthy controls were enrolled, and stool, sputum, and saliva samples were analyzed using both microscopy and qPCR methods. <jats:italic toggle=\"yes\">Cryptosporidium<\/jats:italic> spp. were detected in 13% of CRC patients\u2019 stool samples, compared to 2% in the control group, demonstrating a statistically significant difference (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u20050.0013). In contrast, there was no significant difference in <jats:italic toggle=\"yes\">Cryptosporidium<\/jats:italic> spp. positivity between CRC patients and controls in sputum or saliva samples. Strikingly, one CRC patient had <jats:italic toggle=\"yes\">Cryptosporidium<\/jats:italic> spp. in both sputum and saliva samples in addition to stool, suggesting potential secondary pulmonary involvement. The findings highlight the importance of screening for <jats:italic toggle=\"yes\">Cryptosporidium<\/jats:italic> spp. in CRC patients, particularly those with respiratory symptoms, advanced-stage disease, or left-sided tumors, to ensure timely diagnosis and management of this opportunistic infection. Further research is needed to clarify the pathogen\u2019s role in colorectal carcinogenesis and the implications for patient outcomes.<\/jats:p>","DOI":"10.1097\/cej.0000000000000950","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T07:01:53Z","timestamp":1735887713000},"page":"534-540","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Cryptosporidiosis as an opportunistic infection in colorectal cancer patients"],"prefix":"10.1097","volume":"34","author":[{"given":"Can","family":"Muftuoglu","sequence":"first","affiliation":[{"name":"Department of Basic Oncology, Institute of Health Sciences, Ege University, Izmir, Turkey"},{"name":"Department of Medicine I, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayfun","family":"Yoldas","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Ege University, Izmir"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Bozbiyik","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Ege University, Izmir"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem Ulusan","family":"Bagci","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Division of Medical Parasitology, Faculty of Medicine, Ankara University, Ankara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Ege University, Izmir"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufuk","family":"Mert","sequence":"additional","affiliation":[{"name":"Ataturk Care Vocational School of Health Services, Ege University, Izmir"},{"name":"Translational Pulmonary Research Center, Ege University (EgeSAM), Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Caner","sequence":"additional","affiliation":[{"name":"Department of Basic Oncology, Institute of Health Sciences, Ege University, Izmir, Turkey"},{"name":"Department of Parasitology, Faculty of Medicine, Ege University, Izmir"},{"name":"Translational Pulmonary Research Center, Ege University (EgeSAM), Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"R1-20250930","first-page":"693","article-title":"Cryptosporidium parvum-induced ileo-caecal adenocarcinoma and Wnt signaling in a mouse model.","volume":"7","author":"Benamrouz","year":"2014","journal-title":"Dis Model 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