{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:24:46Z","timestamp":1792121086500,"version":"4.4.0"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1097\/cej.0b013e32801023b3","type":"journal-article","created":{"date-parts":[[2007,4,5]],"date-time":"2007-04-05T08:04:41Z","timestamp":1175760281000},"page":"216-224","source":"Crossref","is-referenced-by-count":24,"title":["Evaluation of mathematical models for breast cancer risk assessment in routine clinical use"],"prefix":"10.1097","volume":"16","author":[{"given":"Peter A.","family":"Fasching","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayada R.","family":"Bani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Nestle-Kr\u00e4mling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim O.","family":"Goecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Niederacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias W.","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Lux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20210128","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/aje\/152.12.1154","article-title":"Familial breast and ovarian cancer: a Swedish population-based register study","volume":"152","author":"Anderson","year":"2000","journal-title":"Am J Epidemiol"},{"key":"R2-8-20210128","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2217\/14796694.2.2.257","article-title":"Risk prediction models for familial breast cancer","volume":"2","author":"Antoniou","year":"2006","journal-title":"Future Oncol"},{"key":"R3-8-20210128","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/(SICI)1098-2272(200002)18:2<173::AID-GEPI6>3.0.CO;2-R","article-title":"Risk models for familial ovarian and breast cancer","volume":"18","author":"Antoniou","year":"2000","journal-title":"Genet Epidemiol"},{"key":"R4-8-20210128","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1038\/sj.bjc.6602175","article-title":"The BOADICEA model of genetic susceptibility to breast and ovarian cancer","volume":"91","author":"Antoniou","year":"2004","journal-title":"Br J Cancer"},{"key":"R5-8-20210128","doi-asserted-by":"crossref","first-page":"R206","DOI":"10.1186\/bcr644","article-title":"Log odds of carrying an ancestral mutation in BRCA1 or BRCA2 for a defined personal and family history in an Ashkenazi Jewish woman (LAMBDA)","volume":"5","author":"Apicella","year":"2003","journal-title":"Breast Cancer Res"},{"key":"R7-8-20210128","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/jnci\/89.3.227","article-title":"Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history","volume":"89","author":"Berry","year":"1997","journal-title":"J Natl Cancer Inst"},{"key":"R8-8-20210128","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1200\/JCO.2002.05.121","article-title":"BRCAPRO validation, sensitivity of genetic testing of BRCA1\/BRCA2, and prevalence of other breast cancer susceptibility genes","volume":"20","author":"Berry","year":"2002","journal-title":"J Clin Oncol"},{"key":"R10-8-20210128","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/jnci\/94.18.1365","article-title":"Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program","volume":"94","author":"Brose","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"R11-8-20210128","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5694\/j.1326-5377.2003.tb05069.x","article-title":"Psychological outcomes and risk perception after genetic testing and counselling in breast cancer: a systematic review","volume":"178","author":"Butow","year":"2003","journal-title":"Med J Aust"},{"key":"R12-8-20210128","first-page":"232","article-title":"Genetic analysis of breast cancer in the cancer and steroid hormone study","volume":"48","author":"Claus","year":"1991","journal-title":"Am J Hum Genet"},{"key":"R13-8-20210128","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/1097-0142(19940201)73:3<643::AID-CNCR2820730323>3.0.CO;2-5","article-title":"Autosomal dominant inheritance of early-onset breast cancer. Implications for risk prediction","volume":"73","author":"Claus","year":"1994","journal-title":"Cancer"},{"key":"R14-8-20210128","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11<2318::AID-CNCR21>3.0.CO;2-Z","article-title":"The genetic attributable risk of breast and ovarian cancer","volume":"77","author":"Claus","year":"1996","journal-title":"Cancer"},{"key":"R15-8-20210128","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1056\/NEJM199705153362002","article-title":"BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer","volume":"336","author":"Couch","year":"1997","journal-title":"N Engl J Med"},{"key":"R16-8-20210128","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0140-6736(03)12342-2","article-title":"Overview of the main outcomes in breast-cancer prevention trials","volume":"361","author":"Cuzick","year":"2003","journal-title":"Lancet"},{"key":"R17-8-20210128","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/jmg.39.4.225","article-title":"Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility","volume":"39","author":"de Jong","year":"2002","journal-title":"J Med Genet"},{"key":"R18-8-20210128","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1086\/302530","article-title":"Penetrances of BRCA1 1675delA and 1135insA with respect to breast cancer and ovarian cancer","volume":"65","author":"Dorum","year":"1999","journal-title":"Am J Hum Genet"},{"key":"R19-8-20210128","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/bcr448","article-title":"Familial risks of breast cancer","volume":"4","author":"Easton","year":"2002","journal-title":"Breast Cancer Res"},{"key":"R20-8-20210128","first-page":"265","article-title":"Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium","volume":"56","author":"Easton","year":"1995","journal-title":"Am J Hum Genet"},{"key":"R21-8-20210128","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1093\/jnci\/94.11.844","article-title":"Pretest prediction of BRCA1 or BRCA2 mutation by risk counselors and the computer model BRCAPRO","volume":"94","author":"Euhus","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"R22-8-20210128","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1055\/s-2004-821050","article-title":"Hereditary breast and ovarian cancer: an update. Part I-molecular basics, genetic counselling and risk calculation","volume":"64","author":"Fasching","year":"2004","journal-title":"Geburtsh Frauenheilk"},{"key":"R23-8-20210128","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S0140-6736(94)91578-4","article-title":"Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium","volume":"343","author":"Ford","year":"1994","journal-title":"Lancet"},{"key":"R24-8-20210128","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1086\/301749","article-title":"Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium","volume":"62","author":"Ford","year":"1998","journal-title":"Am J Hum Genet"},{"key":"R25-8-20210128","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/jnci\/dji128","article-title":"Cancer risk prediction models: a workshop on development, evaluation, and application","volume":"97","author":"Freedman","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"R26-8-20210128","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1093\/jnci\/81.24.1879","article-title":"Projecting individualized probabilities of developing breast cancer for white females who are being examined annually","volume":"81","author":"Gail","year":"1989","journal-title":"J Natl Cancer Inst"},{"key":"R27-8-20210128","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4065\/72.1.54","article-title":"Genetics of breast cancer","volume":"72","author":"Greene","year":"1997","journal-title":"Mayo Clin Proc"},{"key":"R28-8-20210128","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJM199901143400201","article-title":"Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer","volume":"340","author":"Hartmann","year":"1999","journal-title":"N Engl J Med"},{"key":"R29-8-20210128","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/01.ogx.0000151669.38495.2e","article-title":"Efficacy of magnetic resonance imaging and mammography for breast cancer screening in women with a familial or genetic predisposition","volume":"60","author":"Kriege","year":"2005","journal-title":"Obstet Gynecol Surv"},{"key":"R30-8-20210128","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1148\/radiology.215.1.r00ap01267","article-title":"Breast MR imaging screening in 192 women proved or suspected to be carriers of a breast cancer susceptibility gene: preliminary results","volume":"215","author":"Kuhl","year":"2000","journal-title":"Radiology"},{"key":"R31-8-20210128","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00008469-200006000-00001","article-title":"Prevention and therapy for BRCA1\/2 mutation carriers and women at high risk for breast and ovarian cancer","volume":"9","author":"Kuschel","year":"2000","journal-title":"Eur J Cancer Prev"},{"key":"R32-8-20210128","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/gepi.1370050611","article-title":"Programs for pedigree analysis: MENDEL, FISHER, and dGENE","volume":"5","author":"Lange","year":"1988","journal-title":"Genet Epidemiol"},{"key":"R33-8-20210128","first-page":"1059","article-title":"Founder BRCA1 and BRCA2 mutations in Ashkenazi Jews in Israel: frequency and differential penetrance in ovarian cancer and in breast-ovarian cancer families","volume":"60","author":"Levy-Lahad","year":"1997","journal-title":"Am J Hum Genet"},{"key":"R34-8-20210128","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/sj.bjc.6690235","article-title":"Characteristics of small breast and\/or ovarian cancer families with germline mutations in BRCA1 and BRCA2","volume":"79","author":"Ligtenberg","year":"1999","journal-title":"Br J Cancer"},{"key":"R35-8-20210128","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1023\/A:1015269620265","article-title":"One year follow-up of women opting for presymptomatic testing for BRCA1 and BRCA2: emotional impact of the test outcome and decisions on risk management (surveillance or prophylactic surgery)","volume":"73","author":"Lodder","year":"2002","journal-title":"Breast Cancer Res Treat"},{"key":"R36-8-20210128","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/00008469-200512000-00003","article-title":"Age of uptake of early cancer detection facilities by low-risk and high-risk patients with familial breast and ovarian cancer","volume":"14","author":"Lux","year":"2005a","journal-title":"Eur J Cancer Prev"},{"key":"R37-8-20210128","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/00008469-200508000-00014","article-title":"Use of intensified early cancer detection in high-risk patients with familial breast and ovarian cancer","volume":"14","author":"Lux","year":"2005b","journal-title":"Eur J Cancer Prev"},{"key":"R6-8-20210128","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00109-005-0696-7","article-title":"Hereditary breast and ovarian cancer: review and future perspectives","volume":"84","author":"Lux","year":"2006","journal-title":"J Mol Med"},{"key":"R38-8-20210128","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1200\/JCO.2003.05.096","article-title":"Hereditary breast-ovarian cancer at the bedside: role of the medical oncologist","volume":"21","author":"Lynch","year":"2003","journal-title":"J Clin Oncol"},{"key":"R39-8-20210128","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/01.GIM.0000151155.36470.FF","article-title":"Adjusting the estimated proportion of breast cancer cases associated with BRCA1 and BRCA2 mutations: public health implications","volume":"7","author":"McClain","year":"2005","journal-title":"Genet Med"},{"key":"R40-8-20210128","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJM197507312930501","article-title":"Primer on certain elements of medical decision making","volume":"293","author":"McNeil","year":"1975","journal-title":"N Engl J Med"},{"key":"R41-8-20210128","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJM200107193450301","article-title":"Breast cancer after prophylactic bilateral mastectomy in women with a BRCA1 or BRCA2 mutation","volume":"345","author":"Meijers-Heijboer","year":"2001","journal-title":"N Engl J Med"},{"key":"R42-8-20210128","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/ijc.1626","article-title":"Comprehensive analysis of 989 patients with breast or ovarian cancer provides BRCA1 and BRCA2 mutation profiles and frequencies for the German population","volume":"97","author":"Meindl","year":"2002","journal-title":"Int J Cancer"},{"key":"R43-8-20210128","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.7545954","article-title":"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1","volume":"266","author":"Miki","year":"1994","journal-title":"Science"},{"key":"R44-8-20210128","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1086\/301670","article-title":"Determining carrier probabilities for breast cancer-susceptibility genes BRCA1 and BRCA2","volume":"62","author":"Parmigiani","year":"1998","journal-title":"Am J Hum Genet"},{"key":"R45-8-20210128","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/35077207","article-title":"Cancer genetics","volume":"411","author":"Ponder","year":"2001","journal-title":"Nature"},{"key":"R46-8-20210128","first-page":"100S","article-title":"Prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers","volume":"18","author":"Rebbeck","year":"2000","journal-title":"J Clin Oncol"},{"issue":"(Suppl 6)","key":"R47-8-20210128","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/S0959-8049(02)00269-1","article-title":"Prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers","volume":"38","author":"Rebbeck","year":"2002","journal-title":"Eur J Cancer"},{"key":"R48-8-20210128","first-page":"547","article-title":"Genetic heterogeneity in hereditary breast cancer: role of BRCA1 and BRCA2","volume":"59","author":"Rebbeck","year":"1996","journal-title":"Am J Hum Genet"},{"key":"R49-8-20210128","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/oxfordjournals.aje.a114994","article-title":"Familial ovarian cancer: a population-based case\u2013control study","volume":"128","author":"Schildkraut","year":"1988","journal-title":"Am J Epidemiol"},{"key":"R50-8-20210128","first-page":"A1372\/B1146\/C1071","article-title":"Prevention: hereditary breast and ovarian cancer","volume":"20","author":"Schmutzler","year":"2002","journal-title":"Deutsches \u00c4rzteblatt"},{"key":"R51-8-20210128","first-page":"1031","article-title":"BRCA2 in American families with four or more cases of breast or ovarian cancer: recurrent and novel mutations, variable expression, penetrance, and the possibility of families whose cancer is not attributable to BRCA1 or BRCA2","volume":"60","author":"Schubert","year":"1997","journal-title":"Am J Hum Genet"},{"key":"R52-8-20210128","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1001\/jama.1997.03550150046034","article-title":"BRCA1 sequence analysis in women at high risk for susceptibility mutations. Risk factor analysis and implications for genetic testing","volume":"278","author":"Shattuck-Eidens","year":"1997","journal-title":"JAMA"},{"key":"R53-8-20210128","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1056\/NEJM199705153362001","article-title":"The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews","volume":"336","author":"Struewing","year":"1997","journal-title":"N Engl J Med"},{"key":"R54-8-20210128","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/S0959-8049(00)00180-5","article-title":"The requirements of a specialist breast unit","volume":"36","year":"2000","journal-title":"Eur J Cancer"},{"key":"R55-8-20210128","first-page":"1079","article-title":"Study of a single BRCA2 mutation with high carrier frequency in a small population","volume":"60","author":"Thorlacius","year":"1997","journal-title":"Am J Hum Genet"},{"key":"R56-8-20210128","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1023\/A:1006480106487","article-title":"First experiences in screening women at high risk for breast cancer with MR imaging","volume":"63","author":"Tilanus-Linthorst","year":"2000","journal-title":"Breast Cancer Res Treat"},{"key":"R57-8-20210128","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/sim.1668","article-title":"A breast cancer prediction model incorporating familial and personal risk factors","volume":"23","author":"Tyrer","year":"2004","journal-title":"Stat Med"},{"key":"R58-8-20210128","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/378789a0","article-title":"Identification of the breast cancer susceptibility gene BRCA2","volume":"378","author":"Wooster","year":"1995","journal-title":"Nature"}],"container-title":["European Journal of Cancer Prevention"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00008469-200706000-00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T05:42:42Z","timestamp":1618033362000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00008469-200706000-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/cej.0b013e32801023b3","relation":{},"ISSN":["0959-8278"],"issn-type":[{"value":"0959-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}