{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:48:03Z","timestamp":1770893283407,"version":"3.50.1"},"reference-count":60,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Academy of Child &amp; Adolescent Psychiatry"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1097\/chi.0b013e31802f5f2c","type":"journal-article","created":{"date-parts":[[2007,4,9]],"date-time":"2007-04-09T08:03:11Z","timestamp":1176105791000},"page":"524-534","source":"Crossref","is-referenced-by-count":60,"title":["Glutamine and Glutamate Levels in Children and Adolescents With Bipolar Disorder"],"prefix":"10.1016","volume":"46","author":[{"given":"CONSTANCE M.","family":"MOORE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEAN A.","family":"FRAZIER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CAROL A.","family":"GLOD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANIS L.","family":"BREEZE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MEGAN","family":"DIETERICH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHELSEA T.","family":"FINN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BLAISE DEB.","family":"FREDERICK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PERRY F.","family":"RENSHAW","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1097\/chi.0b013e31802f5f2c_bib1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0006-3223(03)00297-X","article-title":"Pediatric bipolar disorder coming of age","volume":"53","author":"Biederman","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0006-3223(00)00911-2","article-title":"Pediatric mania: a developmental subtype of bipolar disorder?","volume":"48","author":"Biederman","year":"2000","journal-title":"Biol Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1749-6632.1987.tb32915.x","article-title":"Spatial localization in NMR spectroscopy in vivo","volume":"508","author":"Bottomley","year":"1987","journal-title":"Ann N Y Acad Sci"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib4","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0278-5846(03)00078-2","article-title":"Glutamine synthetase and glutamate dehydrogenase in the prefrontal cortex of patients with schizophrenia","volume":"27","author":"Burbaeva","year":"2003","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib5","series-title":"Clinical Magnetic Resonance Spectroscopy","author":"Cady","year":"1990"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1034\/j.1399-5618.2002.02235.x","article-title":"Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy","volume":"4","author":"Cecil","year":"2002","journal-title":"Bipolar Disord"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1089\/104454603322724931","article-title":"Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders","volume":"13","author":"Cecil","year":"2003","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1471-4159.1987.tb03389.x","article-title":"Acute and long-term effects of chlorpromazine on glutamine synthetase and glutaminase in rat brain","volume":"49","author":"Chandrakala","year":"1987","journal-title":"J Neurochem"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib9","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1001\/archpsyc.61.8.781","article-title":"Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: a functional magnetic resonance imaging investigation","volume":"61","author":"Chang","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib10","doi-asserted-by":"crossref","first-page":"15653","DOI":"10.1073\/pnas.0507901102","article-title":"Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression","volume":"102","author":"Choudary","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib11","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1046\/j.1471-4159.1994.62031137.x","article-title":"Valproate increases glutaminase and decreases glutamine synthetase activities in primary cultures of rat brain astrocytes","volume":"62","author":"Collins","year":"1994","journal-title":"J Neurochem"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib12","series-title":"The Biochemical Basis of Neuropharmacology","first-page":"105","article-title":"Amino acid transmitters.","author":"Cooper","year":"2003"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0896-6273(03)00195-8","article-title":"Finding the intracellular signaling pathways affected by mood disorder treatments","volume":"38","author":"Coyle","year":"2003","journal-title":"Neuron"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib14","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1001\/archpsyc.61.5.450","article-title":"Brain metabolic alterations in medication-free patients with bipolar disorder","volume":"61","author":"Dager","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0893-133X(00)00207-4","article-title":"Decreased anterior cingulate myo-inositol\/creatine spectroscopy resonance with lithium treatment in children with bipolar disorder","volume":"24","author":"Davanzo","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib16","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1176\/appi.ajp.160.8.1442","article-title":"Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents","volume":"160","author":"Davanzo","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib17","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/sj.npp.1300950","article-title":"Neurochemical effects of olanzapine in first-hospitalization manic adolescents: a proton magnetic resonance spectroscopy study","volume":"31","author":"DelBello","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib18","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0959-4388(00)00203-8","article-title":"Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders","volume":"11","author":"Drevets","year":"2001","journal-title":"Curr Opin Neurobiol"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0006-8993(86)90528-7","article-title":"The role of glial cells in regulation of neurotransmitter amino acids in the external environment. I. Transmembrane electrical and ion gradients and energy parameters in cultured glial-derived cell lines","volume":"369","author":"Erecinska","year":"1986","journal-title":"Brain Res"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib20","series-title":"Structured Clinical Interview for DSM-IV Axis I Disorder-Clinician Version (SCID-CV)","author":"First","year":"1997"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib21","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1038\/sj.bjp.0702472","article-title":"Effects of anti-epileptic drugs on glutamine synthetase activity in mouse brain","volume":"126","author":"Fraser","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib22","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/10673220591003597","article-title":"Magnetic resonance imaging studies in early-onset bipolar disorder: a critical review","volume":"13","author":"Frazier","year":"2005","journal-title":"Harv Rev Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.biopsych.2006.01.024","article-title":"Low cerebrospinal fluid glutamate and glycine in refractory affective disorder","volume":"61","author":"Frye","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib24","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/00004583-199405000-00003","article-title":"Rate and predictors of prepubertal bipolarity during follow-up of 6-to 12-year-old depressed children","volume":"33","author":"Geller","year":"1994","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib25","first-page":"31","article-title":"Bipolar disorder and attention-deficit\/hyperactivity disorder in children and adolescents","volume":"9","author":"Giedd","year":"2000","journal-title":"J Clin Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0197-0186(02)00034-7","article-title":"In vivo 13C NMR studies of compartmentalized cerebral carbohydrate metabolism","volume":"41","author":"Gruetter","year":"2002","journal-title":"Neurochem Int"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/nbm.841","article-title":"Localized in vivo 13C NMR spectroscopy of the brain","volume":"16","author":"Gruetter","year":"2003","journal-title":"NMR Biomed"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib28","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.pnpbp.2003.09.007","article-title":"Glutamatergic neurotransmission modulation and the mechanisms of antipsychotic atypicality","volume":"27","author":"Heresco-Levy","year":"2003","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/mrm.1910390103","article-title":"Measurements of human cerebral GABA at 4.1 T using numerically optimized editing pulses","volume":"39","author":"Hetherington","year":"1998","journal-title":"Magn Reson Med"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib30","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/(SICI)1099-1492(199712)10:8<360::AID-NBM477>3.0.CO;2-8","article-title":"Biological and clinical MRS at ultra-high field","volume":"10","author":"Hetherington","year":"1997","journal-title":"NMR Biomed"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib31","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/sj.jcbfm.9600263","article-title":"Neuronal-glial glucose oxidation and glutamatergic-GABAergic function","volume":"26","author":"Hyder","year":"2006","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib32","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1176\/appi.ajp.162.9.1637","article-title":"Cingulate anatomical abnormalities in children and adolescents with bipolar disorder","volume":"162","author":"Kaur","year":"2005","journal-title":"Am J Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib33","first-page":"15","article-title":"The emerging differential roles of GABAergic and antiglutamatergic agents in bipolar disorders","volume":"64","author":"Ketter","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib34","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3109\/10401230309085675","article-title":"The diverse roles of anticonvulsants in bipolar disorders","volume":"15","author":"Ketter","year":"2003","journal-title":"Ann Clin Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib35","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/S0006-3223(03)00691-7","article-title":"State and trait influences on mood regulation in bipolar disorder: blood flow differences with an acute mood challenge","volume":"54","author":"Kruger","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib36","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1038\/sj.mp.4001021","article-title":"Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments","volume":"7","author":"Krystal","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib37","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0006-3223(03)00069-6","article-title":"Researching the pathophysiology of pediatric bipolar disorder","volume":"53","author":"Leibenluft","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib38","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1097\/00004583-199504000-00012","article-title":"Bipolar disorders in a community sample of older adolescents: prevalence, phenomenology, comorbidity, and course","volume":"34","author":"Lewinsohn","year":"1995","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib39","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.biopsych.2003.10.017","article-title":"Frontal lobe gray matter density decreases in bipolar I disorder","volume":"55","author":"Lyoo","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib40","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0006-2952(86)90206-6","article-title":"Acute and short-term effects of lithium on glutamate metabolism in rat brain","volume":"35","author":"Marcus","year":"1986","journal-title":"Biochem Pharmacol"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib41","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1126\/science.14400","article-title":"Glutamine synthetase: glial localization in brain","volume":"195","author":"Martinez-Hernandez","year":"1977","journal-title":"Science"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib42","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1034\/j.1399-5618.2000.20302.x","article-title":"Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex","volume":"2","author":"Moore","year":"2000","journal-title":"Bipolar Disord"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib43","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s00213-006-0451-y","article-title":"Topiramate raises anterior cingulate cortex glutamine levels in healthy male adults; A 4.0 T magnetic resonance spectroscopy study","volume":"188","author":"Moore","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib44","first-page":"5","article-title":"Magnetic resonance spectroscopy: neurochemistry and treatment effects in affective disorders","volume":"36","author":"Moore","year":"2002","journal-title":"Psychopharmacol Bull"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib45","doi-asserted-by":"crossref","first-page":"13290","DOI":"10.1073\/pnas.95.22.13290","article-title":"Glial reduction in the subgenual prefrontal cortex in mood disorders","volume":"95","author":"Ongur","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib46","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1528-1157.44.s10.5.x","article-title":"An in vitro study of new antiepileptic drugs and astrocytes","volume":"44","author":"Pavone","year":"2003","journal-title":"Epilepsia"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib47","doi-asserted-by":"crossref","first-page":"898","DOI":"10.4088\/JCP.v65n0703","article-title":"Prepubertal bipolar I disorder and bipolar disorder NOS are separable from ADHD","volume":"65","author":"Post","year":"2004","journal-title":"J Clin Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib48","series-title":"Children's Depression Rating Scale, Revised (CDRS-R)","author":"Poznanski","year":"1996"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib49","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1542\/peds.64.4.442","article-title":"A depression rating scale for children","volume":"64","author":"Poznanski","year":"1979","journal-title":"Pediatrics"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib50","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/nbm.698","article-title":"Automatic quantitation of localized in vivo 1H spectra with LCModel","volume":"14","author":"Provencher","year":"2001","journal-title":"NMR Biomed"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib51","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1034\/j.1399-5618.2002.01149.x","article-title":"Cell pathology in bipolar disorder","volume":"4","author":"Rajkowska","year":"2002","journal-title":"Bipolar Disord"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib52","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0006-3223(01)01080-0","article-title":"Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder","volume":"49","author":"Rajkowska","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib53","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.biopsych.2004.07.005","article-title":"Reduced left anterior cingulate volumes in untreated bipolar patients","volume":"56","author":"Sassi","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib54","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/sj.mp.4001711","article-title":"Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research","volume":"10","author":"Stork","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib55","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1471-4159.1991.tb02591.x","article-title":"Glutamine synthetase in oligodendrocytes and astrocytes: new biochemical and immunocytochemical evidence","volume":"56","author":"Tansey","year":"1991","journal-title":"J Neurochem"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib56","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1176\/appi.ajp.159.11.1944","article-title":"Glutamate and glutamine measured with 4.0 T proton MRS in never-treated patients with schizophrenia and healthy volunteers","volume":"159","author":"Theberge","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib57","unstructured":"U.S. Food and Drug Administration (2003), Guidance for Industry and FDA Staff: Criteria for Significant Risk Investigations of Magnetic Resonance Diagnostic Devices. Available at: http:\/\/www.fda.gov\/cdrh\/ode\/guidance\/793.html. Accessed November 7, 2006"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib58","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1089\/104454603322724832","article-title":"Pediatric bipolar disorder: the new perspective on severe mood dysfunction in children","volume":"13","author":"Wozniak","year":"2003","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib59","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br J Psychiatry"},{"key":"10.1097\/chi.0b013e31802f5f2c_bib60","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1034\/j.1399-5618.2000.20304.x","article-title":"fMRI during affect discrimination in bipolar affective disorder","volume":"2","author":"Yurgelun-Todd","year":"2000","journal-title":"Bipolar Disord"}],"container-title":["Journal of the American Academy of Child &amp; Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890856709617056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890856709617056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T07:25:49Z","timestamp":1707809149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890856709617056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0890856709617056"],"URL":"https:\/\/doi.org\/10.1097\/chi.0b013e31802f5f2c","relation":{},"ISSN":["0890-8567"],"issn-type":[{"value":"0890-8567","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}