{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:59:26Z","timestamp":1793134766318,"version":"4.5.0"},"reference-count":104,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), which are characterized by excessive inflammation and accompanied by diffuse injury of alveoli, can result in severe respiratory failures. The morbidity and mortality of patients remain high because the major treatments for ALI\/ARDS are mainly supportive due to the lack of effective therapies. Numerous studies have demonstrated that the aggravation of coronavirus disease 2019 (COVID-19) leads to severe pneumonia and even ARDS. Pyroptosis, a biological process identified as a type of programed cell death, is mainly triggered by inflammatory caspase activation and is directly meditated by the gasdermin protein family, as well as being associated with the secretion and release of pro-inflammatory cytokines. Clinical and experimental evidence corroborates that pyroptosis of various cells in the lung, such as immune cells and structural cells, may play an important role in the pathogenesis of \u201ccytokine storms\u201d in ALI\/ARDS, including those induced by COVID-19. Here, with a focus on ALI\/ARDS and COVID-19, we summarized the recent advances in this field and proposed the theory of an inflammatory cascade in pyroptosis to identify new targets and pave the way for new approaches to treat these diseases.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/cm9.0000000000002425","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T17:00:49Z","timestamp":1672419649000},"page":"2417-2426","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":35,"title":["Molecular mechanisms and roles of pyroptosis in acute lung injury"],"prefix":"10.1097","volume":"135","author":[{"given":"Tianchang","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Shanghai Key Laboratory of Lung Inflammation and Injury, Zhongshan Hospital, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Shanghai Key Laboratory of Lung Inflammation and Injury, Zhongshan Hospital, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanlin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Shanghai Key Laboratory of Lung Inflammation and Injury, Zhongshan Hospital, Fudan University, Shanghai 200032, China"},{"name":"Shanghai Institute of Infectious Disease and Biosecurity, Shanghai 200032, China"},{"name":"Shanghai Respiratory Research Institute, Shanghai 200032, China"},{"name":"Jinshan Hospital of Fudan University, Shanghai 201508, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"R1-20250603","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(67)90168-7","article-title":"Acute respiratory distress in adults","volume":"2","author":"Ashbaugh","year":"1967","journal-title":"Lancet"},{"key":"R2-20250603","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0140-6736(07)60604-7","article-title":"Acute lung injury and the acute respiratory distress syndrome: a clinical review","volume":"369","author":"Wheeler","year":"2007","journal-title":"Lancet"},{"key":"R3-20250603","first-page":"S353","article-title":"Acute lung injury - from pathophysiology to treatment","volume":"69","author":"Mokra","year":"2020","journal-title":"Physiol Res"},{"key":"R4-20250603","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1016\/j.jinf.2020.04.021","article-title":"Risk factors of critical & 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