{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:49:33Z","timestamp":1762375773798},"reference-count":63,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1097\/cmr.0000000000000016","type":"journal-article","created":{"date-parts":[[2013,9,27]],"date-time":"2013-09-27T22:07:59Z","timestamp":1380319679000},"page":"426-433","source":"Crossref","is-referenced-by-count":23,"title":["Chemoprevention of skin melanoma"],"prefix":"10.1097","volume":"23","author":[{"given":"Ma\u0142gorzata","family":"Uzarska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafa\u0142","family":"Czajkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Bajek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Zegarska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Drewa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-2-20210129","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00403-012-1223-7","article-title":"Upcoming strategies for the treatment of metastatic melanoma.","volume":"304","author":"Spagnolo","year":"2012","journal-title":"Arch Dermatol Res"},{"key":"R2-2-20210129","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2133.2004.05708.x","article-title":"Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma.","volume":"150","author":"Lens","year":"2004","journal-title":"Br J Dermatol"},{"key":"R3-2-20210129","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1586\/era.10.170","article-title":"A new understanding in the epidemiology of melanoma.","volume":"10","author":"Erdei","year":"2010","journal-title":"Expert Rev Anticancer Ther"},{"key":"R4-2-20210129","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.clindermatol.2008.09.001","article-title":"Melanoma epidemiology and trends.","volume":"27","author":"Garbe","year":"2009","journal-title":"Clin Dermatol"},{"key":"R5-2-20210129","first-page":"437","article-title":"Skin melanoma: present possibilities of treatment in Poland based on own experiences of melanoma patients course and current review of literature.","volume":"10","author":"Kycler","year":"2006","journal-title":"Wspolcz Onkol"},{"key":"R9-2-20210129","first-page":"267","article-title":"Primary melanoma prevention in children.","volume":"139","author":"Azfar","year":"2004","journal-title":"G Ital Dermatol Venereol"},{"key":"R10-2-20210129","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.critrevonc.2004.11.001","article-title":"Cutaneous melanoma: pathogenesis and rationale for chemoprevention.","volume":"53","author":"Demierre","year":"2005","journal-title":"Crit Rev Oncol Hematol"},{"key":"R11-2-20210129","first-page":"1332","article-title":"Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).","volume":"35","author":"Sporn","year":"1976","journal-title":"Fed Proc"},{"key":"R12-2-20210129","first-page":"2699","article-title":"Approaches to prevention of epithelial cancer during the preneoplastic period.","volume":"36","author":"Sporn","year":"1976","journal-title":"Cancer Res"},{"key":"R13-2-20210129","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mrfmmm.2005.02.029","article-title":"Overview of mechanisms of cancer chemopreventive agents.","volume":"591","author":"De Flora","year":"2005","journal-title":"Mutat Res"},{"key":"R14-2-20210129","first-page":"1857","article-title":"Cancer chemoprevention: a summary of the current evidence.","volume":"28","author":"Bonovas","year":"2008","journal-title":"Anticancer Res"},{"key":"R15-2-20210129","first-page":"1","article-title":"Chemoprevention of cancer.","volume":"45","author":"Wattenberg","year":"1985","journal-title":"Cancer Res"},{"key":"R16-2-20210129","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1093\/carcin\/14.9.1737","article-title":"Cancer chemoprevention: principles and prospects.","volume":"14","author":"Morse","year":"1993","journal-title":"Carcinogenesis"},{"key":"R17-2-20210129","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jaad.2006.04.014","article-title":"Melanoma chemoprevention.","volume":"55","author":"Francis","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"R18-2-20210129","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.bpg.2011.10.012","article-title":"Chemoprevention-history and general principles.","volume":"25","author":"Wu","year":"2011","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"R19-2-20210129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2012.04.011","article-title":"Statins and cancer: current and future prospects.","volume":"324","author":"Osmak","year":"2012","journal-title":"Cancer Lett"},{"key":"R20-2-20210129","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2174\/187152012800228715","article-title":"Statins and protein prenylation in cancer cell biology and therapy.","volume":"12","author":"Garcia-Ruiz","year":"2012","journal-title":"Anticancer Agents Med Chem"},{"key":"R21-2-20210129","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nrc1751","article-title":"Statins and cancer prevention.","volume":"5","author":"Demierre","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"R23-2-20210129","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1038\/jid.2011.58","article-title":"Long-term use of nonsteroidal anti-inflammatory drugs decreases the risk of cutaneous melanoma: results of a United States case-control study.","volume":"131","author":"Curiel-Lewandrowski","year":"2011","journal-title":"J Invest Dermatol"},{"key":"R25-2-20210129","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10654-009-9396-x","article-title":"Can statin therapy reduce the risk of melanoma A meta-analysis of randomized controlled trials.","volume":"25","author":"Bonovas","year":"2010","journal-title":"Eur J Epidemiol"},{"key":"R26-2-20210129","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.numecd.2009.04.011","article-title":"Peroxisome proliferator-activated receptors and angiogenesis.","volume":"19","author":"Biscetti","year":"2009","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"R27-2-20210129","first-page":"359","article-title":"Anti-inflammatory and antithrombotic effects of fibrates.","volume":"9","author":"Undas","year":"2007","journal-title":"Pol J Cardiol"},{"key":"R28-2-20210129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.20998","article-title":"Present concepts and future outlook: function of peroxisome proliferator-activated receptors (PPARs) for pathogenesis, progression, and therapy of cancer.","volume":"212","author":"Sertznig","year":"2007","journal-title":"J Cell Physiol"},{"key":"R31-2-20210129","first-page":"3147","article-title":"Non-steroidal anti-inflammatory drugs in cancer prevention and therapy.","volume":"27","author":"Guadagni","year":"2007","journal-title":"Anticancer Res"},{"key":"R32-2-20210129","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1097\/00042728-200507000-00003","article-title":"Use of cyclooxygenase inhibitors and risk of melanoma in high-risk patients.","volume":"31","author":"Ramirez","year":"2005","journal-title":"Dermatol Surg"},{"key":"R34-2-20210129","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.cca.2010.12.026","article-title":"Cyclooxygenase-2 in oncogenesis.","volume":"412","author":"Rizzo","year":"2011","journal-title":"Clin Chim Acta"},{"key":"R35-2-20210129","first-page":"655","article-title":"Inverse association of non-steroidal anti-inflammatory drugs and malignant melanoma among women.","volume":"8","author":"Harris","year":"2001","journal-title":"Oncol Rep"},{"key":"R36-2-20210129","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1038\/jid.2009.201","article-title":"Non-steroidal anti-inflammatory drugs and melanoma risk: large Dutch population-based case-control study.","volume":"129","author":"Joosse","year":"2009","journal-title":"J Invest Dermatol"},{"key":"R37-2-20210129","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.1002\/cncr.27406","article-title":"Nonsteroidal anti-inflammatory drugs and the risk of skin cancer: a population-based case-control study.","volume":"118","author":"Johannesdottir","year":"2012","journal-title":"Cancer"},{"key":"R39-2-20210129","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/jnci\/djk132","article-title":"A large cohort study of long-term daily use of adult-strength aspirin and cancer incidence.","volume":"99","author":"Jacobs","year":"2007","journal-title":"J Natl Cancer Inst"},{"key":"R40-2-20210129","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/jnci\/djn154","article-title":"A large cohort study of nonsteroidal anti-inflammatory drug use and melanoma incidence.","volume":"100","author":"Asgari","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"R41-2-20210129","doi-asserted-by":"crossref","first-page":"598571","DOI":"10.1155\/2011\/598571","article-title":"Nonsteroidal anti-inflammatory drugs and risk of melanoma.","volume":"2011","author":"Jeter","year":"2011","journal-title":"J Skin Cancer"},{"key":"R44-2-20210129","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/sj.cdd.4400437","article-title":"Differential apoptotic response of human melanoma cells to 1 alpha,25-dihydroxyvitamin D3 and its analogues.","volume":"5","author":"Danielsson","year":"1998","journal-title":"Cell Death Differ"},{"key":"R45-2-20210129","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0022-2143(99)90004-5","article-title":"1alpha,25-dihydroxyvitamin D3 inhibits in vitro invasiveness through the extracellular matrix and in vivo pulmonary metastasis of B16 mouse melanoma.","volume":"133","author":"Yudoh","year":"1999","journal-title":"J Lab Clin Med"},{"key":"R48-2-20210129","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/1523-1747.ep12499962","article-title":"Case-control study of melanoma and dietary vitamin D: implications for advocacy of sun protection and sunscreen use.","volume":"98","author":"Weinstock","year":"1992","journal-title":"J Invest Dermatol"},{"key":"R49-2-20210129","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1038\/jid.2008.451","article-title":"A cohort study of vitamin D intake and melanoma risk.","volume":"129","author":"Asgari","year":"2009","journal-title":"J Invest Dermatol"},{"key":"R51-2-20210129","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00280-008-0763-1","article-title":"Comparison of the in vitro and in vivo effects of retinoids either alone or in combination with cisplatin and 5-fluorouracil on tumor development and metastasis of melanoma.","volume":"63","author":"Liu","year":"2008","journal-title":"Cancer Chemother Pharmacol"},{"key":"R52-2-20210129","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3109\/07357909609012154","article-title":"Isotretinoin and recombinant interferon alfa-2a therapy of metastatic malignant melanoma.","volume":"14","author":"Triozzi","year":"1996","journal-title":"Cancer Invest"},{"key":"R53-2-20210129","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/00000421-199808000-00007","article-title":"Phase II clinical trial of recombinant alpha 2b interferon and 13 cis retinoic acid in patients with metastatic melanoma.","volume":"21","author":"Rosenthal","year":"1998","journal-title":"Am J Clin Oncol"},{"key":"R56-2-20210129","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/j.1524-4725.2012.02362.x","article-title":"Melanoma in situ treated successfully using imiquimod after nonclearance with surgery: review of the literature.","volume":"38","author":"Ellis","year":"2012","journal-title":"Dermatol Surg"},{"key":"R58-2-20210129","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1365-2133.2006.07664.x","article-title":"Phase III study of topical imiquimod and intralesional interleukin-2 in the treatment of accessible metastases in malignant melanoma.","volume":"156","author":"Green","year":"2007","journal-title":"Br J Dermatol"},{"key":"R59-2-20210129","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/med.10033","article-title":"Flavonoids: promising anticancer agents.","volume":"23","author":"Ren","year":"2003","journal-title":"Med Res Rev"},{"key":"R60-2-20210129","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jnutbio.2006.11.004","article-title":"Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention.","volume":"18","author":"Ramos","year":"2007","journal-title":"J Nutr Biochem"},{"key":"R61-2-20210129","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jnutbio.2005.05.011","article-title":"Genistin inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells.","volume":"17","author":"Russo","year":"2006","journal-title":"J Nutr Biochem"},{"key":"R62-2-20210129","first-page":"885","article-title":"Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer.","volume":"16","author":"Farina","year":"2006","journal-title":"Oncol Rep"},{"key":"R63-2-20210129","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00403-009-1001-3","article-title":"Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms.","volume":"302","author":"Nichols","year":"2010","journal-title":"Arch Dermatol Res"},{"key":"R64-2-20210129","doi-asserted-by":"crossref","first-page":"e23000","DOI":"10.1371\/journal.pone.0023000","article-title":"Silymarin targets -catenin signaling in blocking migrationinvasion of humanmelanoma cells.","volume":"6","author":"Vaid","year":"2011","journal-title":"PLoS One"},{"key":"R66-2-20210129","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mrfmmm.2004.06.040","article-title":"Effects of tea polyphenols on signal transduction pathways related to cancer chemoprevention.","volume":"555","author":"Hou","year":"2004","journal-title":"Mutat Res"},{"key":"R67-2-20210129","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.bcp.2011.07.093","article-title":"Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications.","volume":"82","author":"Singh","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"R68-2-20210129","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ijc.20785","article-title":"Anti-proliferative and proapoptotic effects of (-)-epigallocatechin-3-gallate on human melanoma: possible implications for the chemoprevention of melanoma.","volume":"114","author":"Nihal","year":"2005","journal-title":"Int J Cancer"},{"key":"R70-2-20210129","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1096\/fj.01-0300rev","article-title":"Angioprevention: angiogenesis is a common and key target for cancer chemopreventive agents.","volume":"16","author":"Tosetti","year":"2002","journal-title":"FASEB J"},{"key":"R72-2-20210129","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/ecam\/nem140","article-title":"Differential growth suppression of human melanoma cells by tea (Camellia sinensis) epicatechins (ECG, EGC and EGCG).","volume":"6","author":"Ravindranath","year":"2009","journal-title":"Evid Based Complement Alternat Med"},{"key":"R73-2-20210129","first-page":"2783","article-title":"Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.","volume":"24","author":"Aggarwal","year":"2004","journal-title":"Anticancer Res"},{"key":"R74-2-20210129","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.canlet.2008.03.057","article-title":"Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives.","volume":"269","author":"Kundu","year":"2008","journal-title":"Cancer Lett"},{"key":"R75-2-20210129","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0304-3835(02)00676-6","article-title":"Resveratrol is a potent inducer of apoptosis in human melanoma cells.","volume":"190","author":"Niles","year":"2003","journal-title":"Cancer Lett"},{"key":"R76-2-20210129","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1021\/jf030073c","article-title":"Grape polyphenol resveratrol and the related molecule 4-hydroxystilbene induce growth inhibition, apoptosis, S-phase arrest, and upregulation of cyclins A, E, and B1 in human SK-Mel-28 melanoma cells.","volume":"51","author":"Larrosa","year":"2003","journal-title":"J Agric Food Chem"},{"key":"R77-2-20210129","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bbrc.2005.06.073","article-title":"Inhibition of melanoma cell proliferation by resveratrol is correlated with upregulation of quinone reductase 2 and p53.","volume":"334","author":"Hsieh","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"R78-2-20210129","first-page":"363","article-title":"Anticancer potential of curcumin: preclinical and clinical studies.","volume":"23","author":"Aggarwal","year":"2003","journal-title":"Anticancer Res"},{"key":"R79-2-20210129","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1749-8546-6-31","article-title":"Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy.","volume":"6","author":"Mimeault","year":"2011","journal-title":"Chin Med"},{"key":"R80-2-20210129","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/excr.2001.5381","article-title":"Curcumin induces apoptosis in human melanoma cells through a Fas receptorcaspase-8 pathway independent of p53.","volume":"271","author":"Bush","year":"2001","journal-title":"Exp Cell Res"},{"key":"R81-2-20210129","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/cncr.21216","article-title":"Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Rafmitogen-activatedextracellular signal-regulated protein kinase pathway and the Akt pathway.","volume":"104","author":"Siwak","year":"2005","journal-title":"Cancer"},{"key":"R82-2-20210129","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/mnfr.201100307","article-title":"Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1.","volume":"55","author":"Abusnina","year":"2011","journal-title":"Mol Nutr Food Res"},{"key":"R83-2-20210129","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0304-3835(95)03887-3","article-title":"Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds.","volume":"95","author":"Menon","year":"1995","journal-title":"Cancer Lett"}],"container-title":["Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/CMR.0000000000000016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T20:16:25Z","timestamp":1621887385000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00008390-201312000-00002"}},"subtitle":["facts and myths"],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/cmr.0000000000000016","relation":{},"ISSN":["0960-8931"],"issn-type":[{"value":"0960-8931","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}