{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:33:33Z","timestamp":1786120413585,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1097\/cmr.0b013e328350d228","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T05:50:23Z","timestamp":1327989023000},"page":"133-139","source":"Crossref","is-referenced-by-count":8,"title":["Preclinical evaluation of the antineoplastic efficacy of 7-(2-hydroxyethyl)theophylline on melanoma cancer cells"],"prefix":"10.1097","volume":"22","author":[{"given":"Alessandro","family":"Lentini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Tabolacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Nardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palma","family":"Mattioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Provenzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Beninati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20210129","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/sj.cdd.4400723","article-title":"Differentiate or die: the view from Montreal.","volume":"7","author":"Thiele","year":"2000","journal-title":"Cell Death Differ"},{"key":"R2-4-20210129","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/sj.leu.2401714","article-title":"Differentiation therapy in acute myelogenous leukemia (non-APL).","volume":"14","author":"Waxman","year":"2000","journal-title":"Leukemia"},{"key":"R3-4-20210129","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/10408360902982128","article-title":"Vitamin D and differentiation in cancer.","volume":"46","author":"Gocek","year":"2009","journal-title":"Crit Rev Clin Lab Sci"},{"key":"R4-4-20210129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ecam\/nep107","article-title":"Ganoderma lucidum polysaccharides induce macrophage-like differentiation in human leukemia THP-1 cells via caspase and p53 activation.","volume":"2011","author":"Hsu","year":"2009","journal-title":"Evid Based Complement Altern Med"},{"key":"R5-4-20210129","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1055\/s-0029-1186102","article-title":"Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy.","volume":"75","author":"Laszczyk","year":"2009","journal-title":"Planta Med"},{"key":"R6-4-20210129","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3322\/caac.20006","article-title":"Cancer statistics, 2009.","volume":"59","author":"Jemal","year":"2009","journal-title":"CA Cancer J Clin"},{"key":"R7-4-20210129","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.plaphy.2010.02.010","article-title":"Phytochemicals and protein-polyamine conjugates by transglutaminase as chemopreventive and chemotherapeutic tools in cancer.","volume":"48","author":"Lentini","year":"2010","journal-title":"Plant Physiol Biochem"},{"key":"R8-4-20210129","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF02787362","article-title":"Therapeutic efficacy of theophylline in chronic lymphocytic leukemia.","volume":"16","author":"Makower","year":"1999","journal-title":"Med Oncol"},{"key":"R9-4-20210129","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1080\/10428190410001714061","article-title":"Chlorambucil plus theophylline vs chlorambucil alone as a front line therapy for B-cell chronic lymphatic leukemia.","volume":"45","author":"Mabed","year":"2004","journal-title":"Leuk Lymphoma"},{"key":"R10-4-20210129","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/ijc.2910530515","article-title":"Differences in the post-translational modification of proteins by polyamines between weakly and highly metastatic B16 melanoma cells.","volume":"53","author":"Beninati","year":"1993","journal-title":"Int J Cancer"},{"key":"R11-4-20210129","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/00008390-200010000-00005","article-title":"Theophylline administration markedly reduces hepatic and pulmonary implantation of B16-F10 melanoma cells in mice.","volume":"10","author":"Lentini","year":"2000","journal-title":"Melanoma Res"},{"key":"R12-4-20210129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-5793(93)80952-Q","article-title":"Biochemical events in naturally occurring forms of cell death.","volume":"328","author":"Fesus","year":"1993","journal-title":"FEBS Lett"},{"key":"R13-4-20210129","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0968-0004(02)02182-5","article-title":"Transglutaminase 2: an enigmatic enzyme with diverse functions.","volume":"27","author":"Fesus","year":"2002","journal-title":"Trends Biochem Sci"},{"key":"R14-4-20210129","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/BF02623682","article-title":"Cellular transglutaminase has affinity for extracellular matrix.","volume":"23","author":"Upchurch","year":"1987","journal-title":"In Vitro Cell Dev Biol"},{"key":"R15-4-20210129","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00726-008-0190-y","article-title":"Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications.","volume":"36","author":"Collighan","year":"2009","journal-title":"Amino Acids"},{"key":"R16-4-20210129","first-page":"234","article-title":"Post-translational modification of protein in cancer cells: the transglutaminase-catalyzed reactions.","volume":"8","author":"Beninati","year":"1995","journal-title":"Cancer J"},{"key":"R17-4-20210129","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1006\/excr.2001.5356","article-title":"Transglutaminase activity is involved in polyamine-induced programed cell death.","volume":"271","author":"Facchiano","year":"2001","journal-title":"Exp Cell Res"},{"key":"R18-4-20210129","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/oxfordjournals.jbchem.a003197","article-title":"Theophylline-induced apoptosis is paralleled by protein kinase A-dependent tissue transglutaminase activation in cancer cells.","volume":"132","author":"Caraglia","year":"2002","journal-title":"J Biochem"},{"key":"R19-4-20210129","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00726-004-0079-3","article-title":"Protein-polyamine conjugation by transglutaminase in cancer cell differentiation.","volume":"26","author":"Lentini","year":"2004","journal-title":"Amino Acids"},{"key":"R20-4-20210129","first-page":"289","article-title":"Pharmacological studies in animals of beta-hydroxyethyltheophylline, the major metabolite of doxofylline in humans.","volume":"13","author":"Franzone","year":"1991","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"R21-4-20210129","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/CMR.0b013e328339d8ac","article-title":"Similar antineoplastic effects of nimesulide, a selective COX-2 inhibitor, and prostaglandin E1 on B16-F10 murine melanoma cells.","volume":"20","author":"Tabolacci","year":"2010","journal-title":"Melanoma Res"},{"key":"R22-4-20210129","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1089\/cbr.2010.0787","article-title":"Antitumor activity of theophylline in combination with paclitaxel: a preclinical study on melanoma experimental lung metastasis.","volume":"5","author":"Lentini","year":"2010","journal-title":"Cancer Biother Radiopharm"},{"key":"R23-4-20210129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1998.1","article-title":"United Kingdom Coordinating Committee on Cancer Research. Guidelines for the welfare of animals in experimental neoplasia.","volume":"77","author":"Workman","year":"1998","journal-title":"Br J Cancer"},{"key":"R24-4-20210129","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/S0959-8049(00)00147-7","article-title":"Evaluation of the efficacy of potential antineoplastic drugs on tumour metastasis by a computer-assisted image analysis.","volume":"36","author":"Lentini","year":"2000","journal-title":"Eur J Cancer"},{"key":"R25-4-20210129","first-page":"107","article-title":"ATRA(double) in the treatment of acute promyelocytic leukemia.","volume":"15","author":"Ozpolat","year":"2001","journal-title":"J Biol Regul Homeost Agents"},{"key":"R27-4-20210129","first-page":"3761","article-title":"Combined chemotherapy and differentiation therapy in the treatment of advanced non-small-cell lung cancer.","volume":"17","author":"Recchia","year":"1997","journal-title":"Anticancer Res"},{"key":"R28-4-20210129","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ijpharm.2007.01.002","article-title":"Effect of genistein on the pharmacokinetics of paclitaxel administered orally or intravenously in rats.","volume":"337","author":"Li","year":"2007","journal-title":"Int J Pharm"},{"key":"R29-4-20210129","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1021\/jm00157a035","article-title":"Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.","volume":"29","author":"Daly","year":"1986","journal-title":"J Med Chem"},{"key":"R30-4-20210129","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3748\/wjg.14.627","article-title":"Anticancer activity of genistein on implanted tumor of human SG7901 cells in nude mice.","volume":"14","author":"Zhou","year":"2008","journal-title":"World J Gastroenterol"},{"key":"R31-4-20210129","doi-asserted-by":"crossref","first-page":"15308","DOI":"10.1016\/S0021-9258(18)98617-5","article-title":"Cross-linking of laminin-nidogen complexes by tissue transglutaminase. A novel mechanism for basement membrane stabilization.","volume":"266","author":"Aeschlimann","year":"1991","journal-title":"J Biol Chem"},{"key":"R32-4-20210129","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2741\/1863","article-title":"The role of tissue transglutaminase in cell-matrix interactions.","volume":"11","author":"Zemskov","year":"2006","journal-title":"Front Biosci"},{"key":"R33-4-20210129","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00726-007-0505-4","article-title":"Impairment of the metastatic activity of melanoma cells by transglutaminase-catalyzed incorporation of polyamines into laminin and Matrigel.","volume":"34","author":"Lentini","year":"2008","journal-title":"Amino Acids"},{"key":"R34-4-20210129","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1021\/bi00403a015","article-title":"A novel actin label: a fluorescent probe at glutamine-41 and its consequences.","volume":"27","author":"Takashi","year":"1988","journal-title":"Biochemistry"}],"container-title":["Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/CMR.0b013e328350d228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:34:55Z","timestamp":1786048495000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00008390-201204000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/cmr.0b013e328350d228","relation":{},"ISSN":["0960-8931"],"issn-type":[{"value":"0960-8931","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}