{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:11:31Z","timestamp":1786119091067,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,12]]},"abstract":"Abstract<\/jats:title>\n \n Objective:<\/jats:title>\n To report the clinical, electrodiagnostic, and pathologic findings in 3 patients who presented with complex regional pain syndrome as their primary manifestation of peripheral nerve vasculitis.<\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n Case series.<\/jats:p>\n <\/jats:sec>\n \n Setting:<\/jats:title>\n Outpatient clinic in a tertiary care academic medical center.<\/jats:p>\n <\/jats:sec>\n \n Patients:<\/jats:title>\n Patient 1 was a 39-year-old woman with a 9-year history of non-length-dependent severe burning pain and swelling in her extremities. Patient 2 was a 67-year-old man with a 2-year history of severe burning pain and swelling in an extremity after a fall. Patient 3 was a 74-year-old man with a 6-month history of severe allodynic pain and atrophy of the right hand after a viral illness<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n In all 3 cases, clinical and electrodiagnostic testing were suggestive of multiple mononeuropathies. Nerve biopsy either confirmed vasculitis (patient 1) or was suggestive of angiopathy (patients 2 and 3). Immunomodulative therapy led to marked clinical improvement in all 3 cases.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n To our knowledge, this is the first report demonstrating that the inflammatory nerve injury seen with peripheral nerve vasculitis can result in complex regional pain syndrome. Clinical and electrodiagnostic assessments can help in the identification and management of these patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/cnd.0b013e31818d4e8b","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T03:16:51Z","timestamp":1232680611000},"page":"61-64","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Peripheral Nerve Vasculitis Presenting as Complex Regional Pain Syndrome"],"prefix":"10.1097","volume":"10","author":[{"given":"Sindhu","family":"Ramchandren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Chaudhry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Hoke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth B","family":"Murinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Cornblath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn J","family":"Treisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20240808","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0889-857X(05)70233-7","article-title":"Vasculitic neuropathies.","volume":"27","author":"Griffin","year":"2001","journal-title":"Rheum Dis Clin North Am"},{"key":"R2-6-20240808","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1085-9489.2006.00060.x","article-title":"Combined nerve and muscle biopsy in the diagnosis of vasculitic neuropathy. A 16-year retrospective study of 202 cases.","volume":"11","author":"Vital","year":"2006","journal-title":"J Peripher Nerv Syst"},{"key":"R4-6-20240808","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11926-002-0012-2","article-title":"Reflex sympathetic dystrophy.","volume":"4","author":"Schwartzman","year":"2002","journal-title":"Curr Rheumatol Rep"},{"key":"R5-6-20240808","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1034\/j.1600-0404.2000.101004262x.\/","article-title":"Neurological findings in complex regional pain syndromes-analysis of 145 cases.","volume":"101","author":"Birklein","year":"2000","journal-title":"Acta Neurol Scand"},{"key":"R6-6-20240808","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.pain.2005.11.015","article-title":"Is CRPS I a neuropathic pain syndrome?","volume":"120","author":"Janig","year":"2006","journal-title":"Pain"},{"key":"R7-6-20240808","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.pain.2006.05.015","article-title":"Is CRPS I a neuropathic pain syndrome?","volume":"123","author":"Ochoa","year":"2006","journal-title":"Pain"},{"key":"R8-6-20240808","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1212\/WNL.57.12.2179","article-title":"The significant role of neuropeptides in complex regional pain syndrome.","volume":"57","author":"Birklein","year":"2001","journal-title":"Neurology"},{"key":"R9-6-20240808","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/01.ajp.0000169669.70523.f0","article-title":"Inflammatory mediators are altered in the acute phase of posttraumatic complex regional pain syndrome.","volume":"22","author":"Schinkel","year":"2006","journal-title":"Clin J Pain"},{"key":"R10-6-20240808","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1212\/WNL.51.1.20","article-title":"Complex regional pain syndrome type I (RSD): pathology of skeletal muscle and peripheral nerve.","volume":"51","author":"van der Laan","year":"1998","journal-title":"Neurology"},{"key":"R11-6-20240808","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1177\/096120339900800611","article-title":"Reflex sympathetic dystrophy in a patient with the antiphospholipid syndrome.","volume":"8","author":"Tsutsumi","year":"1999","journal-title":"Lupus"},{"key":"R12-6-20240808","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pain.2005.09.036","article-title":"Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy).","volume":"120","author":"Oaklander","year":"2006","journal-title":"Pain"},{"key":"R13-6-20240808","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.pain.2005.10.035","article-title":"Pathological alterations of cutaneous innervation and vasculature in affected limbs from patients with complex regional pain syndrome.","volume":"120","author":"Albrecht","year":"2006","journal-title":"Pain"}],"container-title":["Journal of Clinical Neuromuscular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00131402-200812000-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:32:03Z","timestamp":1786037523000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00131402-200812000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/cnd.0b013e31818d4e8b","relation":{},"ISSN":["1522-0443"],"issn-type":[{"value":"1522-0443","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}