{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T11:49:01Z","timestamp":1759146541505},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>The purpose of this study was to evaluate anti-inflammatory drugs in the medium- and long-term management of mild to moderate carpal tunnel syndrome (CTS). The authors conducted a systematic review of the literature on the effectiveness of steroidal and nonsteroidal anti-inflammatory drugs for mild and moderate cases of CTS. There were included only randomized, double-blind clinical trials. Six publications referring to five trials were included in the review. No study on nonsteroidal anti-inflammatory drugs met our inclusion criteria. Although neurophysiological studies have not shown great differences resulting from the application of corticosteroids, the symptomatic benefit provided by such drugs is clear. In the short term, local infiltration provides better results than systemic administration of corticosteroids. Over a 1-year period, however, this difference does not persist. Further double-blind randomized trials evaluating therapeutic efficacy for a longer follow-up period are required to provide stronger evidence for both steroidal and nonsteroidal anti-inflammatories.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/cnd.0b013e3181ac8364","type":"journal-article","created":{"date-parts":[[2009,8,30]],"date-time":"2009-08-30T07:12:32Z","timestamp":1251616352000},"page":"22-30","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["A Systematic Review of Anti-inflammatories for Mild to Moderate Carpal Tunnel Syndrome"],"prefix":"10.1097","volume":"11","author":[{"given":"Pedro Tadao","family":"Hamamoto Filho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio Vicente","family":"Leite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Antonio","family":"de Lima Resende","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-3-20240808","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1212\/WNL.53.8.1654","article-title":"Multiperspective assessment of carpal tunnel syndrome: a multicenter study.","volume":"53","author":"Padua","year":"1999","journal-title":"Neurology"},{"key":"R2-3-20240808","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1177\/1753193408087119","article-title":"A practical electrophysiological guide for non-surgical and surgical treatment of carpal tunnel syndrome.","volume":"33","author":"Chang","year":"2008","journal-title":"J Hand Surg Eur Vol"},{"key":"R3-3-20240808","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/mus.880180615","article-title":"Editorial comment.","volume":"18","author":"Eisen","year":"1995","journal-title":"Muscle Nerve"},{"key":"R4-3-20240808","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1212\/01.WNL.0000169017.79374.93","article-title":"A randomized controlled trial of surgery vs steroid injection for carpal tunnel syndrome.","volume":"64","author":"Hui","year":"2005","journal-title":"Neurology"},{"key":"R5-3-20240808","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1136\/pgmj.2007.058206","article-title":"Primary care management of patients with carpal tunnel syndrome referred to surgeons: are non-operative interventions effectively utilised?","volume":"83","author":"Burke","year":"2007","journal-title":"Postgrad Med J"},{"key":"R6-3-20240808","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/0269215507077294","article-title":"A systematic review of conservative treatment of carpal tunnel syndrome.","volume":"21","author":"Piazzini","year":"2007","journal-title":"Clin Rehabil"},{"key":"R7-3-20240808","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1212\/WNL.56.11.1459","article-title":"Multiperspective follow-up of untreated carpal tunnel syndrome: a multicenter study.","volume":"56","author":"Padua","year":"2001","journal-title":"Neurology"},{"key":"R8-3-20240808","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.clinph.2008.02.012","article-title":"Natural evolution of carpal tunnel syndrome in untreated patients.","volume":"119","author":"Ortiz-Corredor","year":"2008","journal-title":"Clin Neurophysiol"},{"key":"R9-3-20240808","first-page":"301","article-title":"The natural history of carpal tunnel syndrome. 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