{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:36:52Z","timestamp":1770478612035,"version":"3.49.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>We present a case of a 60-year-old man with mild type 2 diabetes mellitus and step-wise progression of bilateral lower limb weakness, numbness, and pain over a 1-year period. At the time of evaluation, he used a walker. He had elevated cerebrospinal fluid protein, abnormal cooling and heat-pain thresholds on quantitative sensory testing, and nerve conduction studies\/electromyography consistent with bilateral lumbosacral radiculoplexus neuropathies. Because it was not clear whether the disease was still active, a right superficial peroneal nerve biopsy was performed and showed evidence of active axonal degeneration, ischemic injury, and microvasculitis. On the basis of these results, the patient was diagnosed with diabetic lumbosacral radiculoplexus neuropathy and was treated with weekly intravenous methylprednisolone with marked improvement of neurologic symptoms and signs. This case illustrates the typical clinical, electrophysiologic, and pathologic features of diabetic lumbosacral radiculoplexus neuropathy and the utility of nerve biopsy to judge ongoing disease activity.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/cnd.0b013e3181b1eb6d","type":"journal-article","created":{"date-parts":[[2009,8,30]],"date-time":"2009-08-30T03:12:32Z","timestamp":1251601952000},"page":"44-48","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":34,"title":["Microvasculitis in Diabetic Lumbosacral Radiculoplexus Neuropathy"],"prefix":"10.1097","volume":"11","author":[{"given":"Jennifer A","family":"Tracy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JaNean K","family":"Engelstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P James B","family":"Dyck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-6-20240808","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/ana.410040605","article-title":"Introduction of automated systems to evaluate touch-pressure, vibration, and thermal cutaneous sensation in man.","volume":"4","author":"Dyck","year":"1978","journal-title":"Ann Neurol"},{"key":"R2-6-20240808","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1212\/WNL.43.8.1500","article-title":"Cool, warm, and heat-pain detection of receptors: testing methods and inferences about anatomic distribution of receptors.","volume":"43","author":"Dyck","year":"1993","journal-title":"Neurology"},{"key":"R3-6-20240808","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1136\/bmj.2.4951.1287","article-title":"Diabetic amyotrophy.","volume":"2","author":"Garland","year":"1955","journal-title":"Br Med J"},{"key":"R4-6-20240808","first-page":"725","article-title":"Diabetic polyradiculopathy: clinical and electromyographic findings in 105 patients.","volume":"56","author":"Bastron","year":"1981","journal-title":"Mayo Clin Proc"},{"key":"R5-6-20240808","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1212\/WNL.26.2.108","article-title":"Subacute proximal diabetic neuropathy.","volume":"26","author":"Williams","year":"1976","journal-title":"Neurology"},{"key":"R6-6-20240808","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1212\/WNL.43.4.817","article-title":"The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: The Rochester Diabetic Neuropathy Study.","volume":"43","author":"Dyck","year":"1993","journal-title":"Neurology"},{"key":"R7-6-20240808","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1212\/WNL.53.9.2113","article-title":"Microvasculitis and ischemia in diabetic lumbosacral radiculoplexus neuropathy.","volume":"53","author":"Dyck","year":"1999","journal-title":"Neurology"},{"key":"R8-6-20240808","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0022-510X(82)90014-4","article-title":"Diabetic proximal neuropathy: clinical and electromyographic studies.","volume":"53","author":"Subramony","year":"1982","journal-title":"J Neurol Sci"},{"key":"R9-6-20240808","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1093\/brain\/124.6.1197","article-title":"Non-diabetic lumbosacral radiculoplexus neuropathy. Natural history, outcome and comparison with the diabetic variety.","volume":"124","author":"Dyck","year":"2001","journal-title":"Brain"},{"key":"R10-6-20240808","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/mus.10080","article-title":"Diabetic and non-diabetic lumbosacral radiculoplexus neuropathies: New insights into pathophysiology and treatment.","volume":"25","author":"Dyck","year":"2002","journal-title":"Muscle Nerve"},{"key":"R11-6-20240808","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00401-007-0326-2","article-title":"Inflammatory mediators in diabetic and non-diabetic lumbosacral radiculoplexus neuropathy.","volume":"115","author":"Kawamura","year":"2008","journal-title":"Acta Neuropathol"},{"key":"R12-6-20240808","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/ana.410350509","article-title":"Nerve biopsy findings in different patterns of proximal diabetic neuropathy.","volume":"35","author":"Said","year":"1994","journal-title":"Ann Neurol"},{"key":"R13-6-20240808","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/archneur.1995.00540350039015","article-title":"Successful treatment of neuropathies in patients with diabetes mellitus.","volume":"52","author":"Krendel","year":"1995","journal-title":"Arch Neurol"},{"key":"R14-6-20240808","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.4065\/72.12.1123","article-title":"Subacute diabetic proximal neuropathy.","volume":"72","author":"Pascoe","year":"1997","journal-title":"Mayo Clin Proc"}],"container-title":["Journal of Clinical Neuromuscular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00131402-200909000-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T19:25:58Z","timestamp":1723145158000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00131402-200909000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/cnd.0b013e3181b1eb6d","relation":{},"ISSN":["1522-0443"],"issn-type":[{"value":"1522-0443","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}