{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:03:58Z","timestamp":1792375438294,"version":"4.4.0"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Infection with hepatitis C virus (HCV) can be associated with demyelinating polyneuropathy that may be responsive to immunomodulatory therapy. In this case report series, we review four patients (all male, ages 47-60 years) with HCV and demyelinating polyneuropathy. Two of the four patients were diagnosed with HCV during the course of initial neuropathy evaluation. All patients had sensory loss, absent\/diminished reflexes, lower extremity weakness (except for one patient), and demyelinating electrodiagnostic features. Three patients had polyclonal hypergammaglobulinemia and one patient had IgM monoclonal gammopathy. Intravenous immunoglobulin resulted in improvement in three patients; one patient had no benefit from rituximab therapy, but his symptoms have been stable. Demyelinating neuropathy may develop in patients with HCV unrelated to antiviral therapy. Immunomodulatory therapy may be beneficial in some cases. Testing for HCV should be considered, especially in patients with hypergammaglobulinemia or IgM monoclonal gammopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/cnd.0b013e3181b701c1","type":"journal-article","created":{"date-parts":[[2010,5,30]],"date-time":"2010-05-30T11:34:19Z","timestamp":1275219259000},"page":"209-212","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Demyelinating Neuropathy in Patients With Hepatitis C Virus Infection"],"prefix":"10.1097","volume":"11","author":[{"given":"Russell L","family":"Chin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard W","family":"Sander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H","family":"Brannagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"De Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Latov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20240808","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1136\/jnnp.2005.081570","article-title":"Prevalence and characteristics of peripheral neuropathy in hepatitis C virus population.","volume":"77","author":"Santoro","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R2-5-20240808","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1212\/01.WNL.0000131899.33969.E5","article-title":"Improvement of a CIDP associated with hepatitis C virus infection using antiviral therapy.","volume":"63","author":"Corcia","year":"2004","journal-title":"Neurology"},{"key":"R3-5-20240808","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/mus.20517","article-title":"Lewis-Sumner syndrome in hepatitis C virus infection: a possible pathogenetic association with therapeutic problems.","volume":"34","author":"Caporale","year":"2006","journal-title":"Muscle Nerve"},{"key":"R4-5-20240808","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/(SICI)1097-4598(200003)23:3<433::AID-MUS17>3.0.CO;2-O","article-title":"Chronic inflammatory demyelinating polyneuropathy after treatment with interferon-.","volume":"23","author":"Meriggioli","year":"2000","journal-title":"Muscle Nerve"},{"key":"R5-5-20240808","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1529-8027.2006.00108.x","article-title":"Steroid-responsive demyelinating motor neuropathy with conduction block associated with hepatitis C infection and treatment with interferon alpha.","volume":"11","author":"Couto","year":"2006","journal-title":"J Peripher Nerv Syst"},{"key":"R6-5-20240808","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1468-1331.2006.01278.x","article-title":"European Federation of Neurological Sciences\/Peripheral Nerve Society guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society.","volume":"13","author":"Hughes","year":"2006","journal-title":"Eur J Neurol"},{"key":"R7-5-20240808","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/01.md.0000157397.30055.c9","article-title":"Sjogren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases.","volume":"84","author":"Ramos-Casals","year":"2005","journal-title":"Medicine"},{"key":"R8-5-20240808","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1001\/jama.297.18.2010","article-title":"Risk of non-Hodgkin lymphoma and lymphoproliferative precursor diseases in US veterans with hepatitis C virus.","volume":"297","author":"Giordano","year":"2007","journal-title":"JAMA"}],"container-title":["Journal of Clinical Neuromuscular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00131402-201006000-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:24:50Z","timestamp":1786040690000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00131402-201006000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/cnd.0b013e3181b701c1","relation":{},"ISSN":["1522-0443"],"issn-type":[{"value":"1522-0443","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}