{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:21:51Z","timestamp":1786119711445,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Neurologic manifestations of copper deficiency in adults are increasingly recognized. We sought to determine if copper supplementation over a period of 12 months would improve functional activities of daily living (ADLs) in patients with copper deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We studied 15 consecutively diagnosed patients with copper deficiency that received 12 months of copper supplementation. Functional ADLs were evaluated by the Barthel Index (BI), administered at the time of diagnosis and repeated after 12 months of copper supplementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      BI scores were significantly higher after 12 months of continued supplementation when compared with initial scores [(mean \u00b1 SD), 74 \u00b1 11.7 versus 83 \u00b1 13.2,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007, paired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test]. A significant inverse linear correlation between the duration of symptoms before treatment and the change in the BI scores was noted (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Early initiation and sustained supplementation with copper for at least 12 months may improve functional ADLs in patients with copper deficiency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/cnd.0b013e3181dc34c0","type":"journal-article","created":{"date-parts":[[2011,2,12]],"date-time":"2011-02-12T10:36:19Z","timestamp":1297506979000},"page":"122-128","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Copper Supplementation Improves Functional Activities of Daily Living in Adults With Copper Deficiency"],"prefix":"10.1097","volume":"12","author":[{"given":"Calin I","family":"Prodan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meheroz","family":"Rabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea S","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda D","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-3-20240808","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.4065\/81.10.1371","article-title":"Copper deficiency myelopathy (human swayback).","volume":"81","author":"Kumar","year":"2006","journal-title":"Mayo Clin Proc"},{"key":"R3-3-20240808","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s004150170118","article-title":"Copper deficiency-associated myelopathy in a 46-year-old woman.","volume":"248","author":"Schleper","year":"2001","journal-title":"J Neurol"},{"key":"R4-3-20240808","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1182\/blood-2002-01-0256","article-title":"Copper deficiency masquerading as myelodysplastic syndrome.","volume":"100","author":"Gregg","year":"2002","journal-title":"Blood"},{"key":"R5-3-20240808","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1212\/01.WNL.0000032497.30439.F6","article-title":"CNS demyelination associated with copper deficiency and hyperzincemia.","volume":"59","author":"Prodan","year":"2002","journal-title":"Neurology"},{"key":"R6-3-20240808","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00415-004-0428-x","article-title":"Myeloneuropathy and anemia due to copper malabsorption.","volume":"251","author":"Kumar","year":"2004","journal-title":"J Neurol"},{"key":"R7-3-20240808","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/mus.20631","article-title":"Motor neuron disease associated with copper deficiency.","volume":"34","author":"Weihl","year":"2006","journal-title":"Muscle Nerve"},{"key":"R8-3-20240808","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1007\/s00415-006-0479-2","article-title":"Myelo-optico-neuropathy in copper deficiency occurring after partial gastrectomy. Do small bowel bacterial overgrowth syndrome and occult zinc ingestion tip the balance?","volume":"254","author":"Spinazzi","year":"2007","journal-title":"J Neurol"},{"key":"R9-3-20240808","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/jnnp.2008.144683","article-title":"Clinical and electrodiagnostic findings in copper deficiency myeloneuropathy.","volume":"80","author":"Goodman","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R10-3-20240808","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1212\/01.WNL.0000132644.52613.FA","article-title":"Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration.","volume":"63","author":"Kumar","year":"2004","journal-title":"Neurology"},{"key":"R11-3-20240808","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/CND.0b013e3181828cf7","article-title":"Response to oral supplementation in copper deficiency myeloneuropathy.","volume":"10","author":"Kelkar","year":"2008","journal-title":"J Clin Neuromuscul Dis"},{"key":"R12-3-20240808","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1136\/jnnp.2006.096883","article-title":"Relapsing hypocupraemic myelopathy requiring high-dose oral copper replacement.","volume":"77","author":"Prodan","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R13-3-20240808","first-page":"61","article-title":"Functional evaluation: the Barthel index.","volume":"14","author":"Mahoney","year":"1965","journal-title":"Md State Med J"},{"key":"R14-3-20240808","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3109\/09638288809164105","article-title":"The Barthel ADL Index: a standard measure of physical disability?","volume":"10","author":"Wade","year":"1988","journal-title":"Int Disabil Stud"},{"key":"R15-3-20240808","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1093\/ptj\/68.7.1077","article-title":"Reliability of the Modified Motor Assessment Scale and the Barthel Index.","volume":"68","author":"Loewen","year":"1988","journal-title":"Phys Ther"},{"key":"R16-3-20240808","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1161\/01.STR.22.10.1242","article-title":"Assessment of scales of disability and handicap for stroke patients.","volume":"22","author":"Wolfe","year":"1991","journal-title":"Stroke"},{"key":"R17-3-20240808","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/jnnp.50.2.177","article-title":"Functional abilities after stroke: measurement, natural history and prognosis.","volume":"50","author":"Wade","year":"1987","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R18-3-20240808","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0895-4356(95)00559-5","article-title":"Responsiveness of the rehabilitation activities profile and the Barthel index.","volume":"49","author":"Van Bennekom","year":"1996","journal-title":"J Clin Epidemiol"},{"key":"R19-3-20240808","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/S0895-4356(02)00410-9","article-title":"Comparison of the responsiveness of the Barthel Index and the motor component of the functional independence measure in stroke: the impact of using different methods for measuring responsiveness.","volume":"55","author":"Wallace","year":"2002","journal-title":"J Clin Epidemiol"},{"key":"R20-3-20240808","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1212\/01.wnl.0000312375.79881.94","article-title":"Denture cream: an unusual source of excess zinc, leading to hypocupremia and neurologic disease.","volume":"71","author":"Nations","year":"2008","journal-title":"Neurology"},{"key":"R21-3-20240808","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.neuro.2009.08.008","article-title":"Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin II. The denture cream is a primary source of excessive zinc.","volume":"30","author":"Hedera","year":"2009","journal-title":"Neurotoxicology"},{"key":"R22-3-20240808","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1212\/WNL.47.2.388","article-title":"Factors predictive of stroke outcome in a rehabilitation setting.","volume":"47","author":"Ween","year":"1996","journal-title":"Neurology"},{"key":"R23-3-20240808","first-page":"1","article-title":"The effect of age on maintenance of functional gains following stroke rehabilitation.","volume":"6","author":"Borucki","year":"1992","journal-title":"J Neurorehabil"},{"key":"R24-3-20240808","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1177\/1545968306294729","article-title":"Establishing the minimal clinically important difference of the Barthel Index in stroke patients.","volume":"21","author":"Hsieh","year":"2007","journal-title":"Neurorehabil Neural Repair"},{"key":"R25-3-20240808","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1001\/archneur.60.12.1782","article-title":"Myelopathy due to copper deficiency following gastrointestinal surgery.","volume":"60","author":"Kumar","year":"2003","journal-title":"Arch Neurol"},{"key":"R26-3-20240808","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/S1542-3565(04)00546-4","article-title":"Acquired hypocupremia after gastric surgery.","volume":"2","author":"Kumar","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R27-3-20240808","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/MAJ.0b013e31818ad0ff","article-title":"Copper deficiency after gastric surgery: a reason for caution.","volume":"337","author":"Prodan","year":"2009","journal-title":"Am J Med Sci"},{"key":"R28-3-20240808","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1212\/01.wnl.0000262768.40174.33","article-title":"Neurologic complications of gastric bypass surgery for morbid obesity.","volume":"68","author":"Juhasz-Pocsine","year":"2007","journal-title":"Neurology"}],"container-title":["Journal of Clinical Neuromuscular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00131402-201103000-00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:57:54Z","timestamp":1786042674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00131402-201103000-00003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/cnd.0b013e3181dc34c0","relation":{},"ISSN":["1522-0443"],"issn-type":[{"value":"1522-0443","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}