{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:32:01Z","timestamp":1786120321501,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Conduction block (CB) from focal neuropathy is often associated with weakness and fatigue in affected muscles. Ulnar neuropathy at the elbow (UNE) provides an excellent model to examine the relationships between electrophysiologically defined CB and quantitative measurement of weakness and fatigue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Eight healthy control subjects (47 \u00b1 14 years) and nine patients (53 \u00b1 3 years) with clinical and electrophysiological features of UNE with CB were studied. All underwent bilateral, ulnar motor nerve conduction studies recording from the first dorsal interosseous muscle as well as quantitative measurement of strength and fatigue of the first dorsal interosseous with a custom dynamometer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Strength and fatigue were similar in the dominant and nondominant hands of control subjects and unaffected limb in patients. Varying degrees of conduction block (14-62%, mean 36%) and conduction slowing (31 m\/s \u00b1 7) were observed in those with UNE. CB was associated with significant reductions in strength (42%) and fatigue (23%) on a timed fatigue task. The reductions in strength (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.74) and fatigue (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.60) were strongly correlated with the degree of CB.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CB in UNE defined by electrophysiological criteria was strongly correlated with weakness and fatigue in the first dorsal interosseous. Fatigue may be simply related to the reduction in strength, but activity or frequency dependent CB may also contribute.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/cnd.0b013e3181e943ed","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T15:51:21Z","timestamp":1317743481000},"page":"38-45","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Demyelinating Ulnar Nerve Injury on Strength and Fatigue"],"prefix":"10.1097","volume":"13","author":[{"given":"Matti D","family":"Allen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J","family":"Doherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-4-20240808","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/16501970410033677","article-title":"Long-term 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humans.","volume":"23","author":"Sohn","year":"2000","journal-title":"Muscle Nerve"},{"key":"R10-4-20240808","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0733-8619(05)70333-9","article-title":"Diagnosis and management of common compression and entrapment neuropathies.","volume":"15","author":"Campbell","year":"1997","journal-title":"Neurol Clin"},{"key":"R12-4-20240808","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1093\/brain\/123.8.1602","article-title":"Activity-dependent conduction block in multifocal motor neuropathy.","volume":"123","author":"Kaji","year":"2000","journal-title":"Brain"},{"key":"R13-4-20240808","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/mus.20513","article-title":"Frequency-dependent conduction block in carpal tunnel syndrome.","volume":"33","author":"Watson","year":"2006","journal-title":"Muscle 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