{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:21:50Z","timestamp":1786119710990,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To compare results of quantitative sudomotor axon reflex testing (QSART), dorsal sural, and sural sensory nerve testing in patients with painful sensory neuropathy (PSN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Fifty-six patients with symptoms and neurologic examinations consistent with PSN who had both autonomic and nerve conduction studies were identified from 376 patients with a clinical diagnosis of painful neuropathy. Cases were clinically categorized as large-fiber or small-fiber neuropathies by described criteria. The results of sural, dorsal sural, and QSART tests were then analyzed in relationship to these two clinical groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Evidence of unmyelinated fiber abnormalities by QSART was noted in 85% of clinical large-fiber and 69% of clinical small-fiber groups. Dorsal sural potentials were absent in all the large-fiber group but also in 52% of clinically classified small-fiber neuropathies. When QSART and dorsal sural abnormalities were combined, the identification of abnormalities in all the cases of PSN was 89% with 75% of cases (42) showing mixed large and small fiber abnormalities, 14% unmyelinated sensory fiber abnormalities (by QSART), and 11% normal studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study demonstrates the value of combining both QSART and dorsal sural sensory testing in verifying the diagnosis of PSN. The majority of cases demonstrate involvement of unmyelinated C fibers as well as large\/medium myelinated fibers, thereby separating mixed large- and small-fiber sensory neuropathies from those cases classified by clinical criteria solely as small-fiber neuropathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/cnd.0b013e318209efb1","type":"journal-article","created":{"date-parts":[[2011,2,12]],"date-time":"2011-02-12T10:36:19Z","timestamp":1297506979000},"page":"138-142","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of Sudomotor and Sensory Nerve Testing in Painful Sensory Neuropathies"],"prefix":"10.1097","volume":"12","author":[{"given":"James M","family":"Killian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Smyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudy","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishan","family":"Adhikari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadollah","family":"Harati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20240808","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jns.2004.08.012","article-title":"Small fiber neuropathy: a common and important clinical disorder.","volume":"227","author":"Hoitsma","year":"2004","journal-title":"J Neurol Sci"},{"key":"R2-5-20240808","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/mus.10181","article-title":"Small-fiber neuropathy.","volume":"26","author":"Lacomis","year":"2002","journal-title":"Muscle Nerve"},{"key":"R3-5-20240808","first-page":"275","article-title":"Sudomotor function in familial dysautonomia.","volume":"75","author":"Bickel","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R4-5-20240808","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/ana.410140513","article-title":"Quantitative sudomotor axon reflex test in normal and neuropathic subjects.","volume":"14","author":"Low","year":"1983","journal-title":"Ann Neurol"},{"key":"R5-5-20240808","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/mus.20551","article-title":"Detection of small-fiber neuropathy by sudomotor testing.","volume":"34","author":"Low","year":"2006","journal-title":"Muscle Nerve"},{"key":"R6-5-20240808","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1212\/WNL.56.7.861","article-title":"Autonomic impairment in painful neuropathy.","volume":"56","author":"Novak","year":"2001","journal-title":"Neurology"},{"key":"R7-5-20240808","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/mus.880150605","article-title":"Distal small fiber neuropathy: results of tests of sweating and autonomic cardiovascular reflexes.","volume":"15","author":"Stewart","year":"1992","journal-title":"Muscle Nerve"},{"key":"R8-5-20240808","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/mus.1074","article-title":"Clinical utility of dorsal sural nerve conduction studies.","volume":"24","author":"Killian","year":"2001","journal-title":"Muscle Nerve"},{"key":"R10-5-20240808","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data.","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"R12-5-20240808","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1212\/WNL.53.8.1641","article-title":"Painful sensory neuropathy: prospective evaluation using skin biopsy.","volume":"53","author":"Periquet","year":"1999","journal-title":"Neurology"},{"key":"R13-5-20240808","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1212\/WNL.56.11.1570","article-title":"Large-fiber neuropathy in distal sensory neuropathy with normal routine nerve conduction.","volume":"56","author":"Oh","year":"2001","journal-title":"Neurology"},{"key":"R14-5-20240808","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1093\/brain\/awn093","article-title":"The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology.","volume":"131","author":"Devigili","year":"2008","journal-title":"Brain"}],"container-title":["Journal of Clinical Neuromuscular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00131402-201103000-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:57:55Z","timestamp":1786042675000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00131402-201103000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/cnd.0b013e318209efb1","relation":{},"ISSN":["1522-0443"],"issn-type":[{"value":"1522-0443","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}