{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:23:38Z","timestamp":1792545818039,"version":"4.5.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec>\n            <jats:title>ABSTRACT<\/jats:title>\n            <jats:p>Morvan syndrome is characterized by central, autonomic, and peripheral hyperactivity. Examples of central hyperactivity include confusion, memory problems, hallucinations, insomnia, and myoclonus; examples of autonomic hyperactivity include hyperhidrosis and fluctuations in blood pressure; examples of peripheral hyperreactivity include clinical or electrophysiological evidence of painful cramps, myokymia, and neuromyotonia. We present a typical case of Morvan syndrome and the first detailed review of the clinical and therapeutic literature of all 27 cases from the English language literature. Morvan syndrome is considered to be an autoimmune disorder and antibodies against voltage-gated potassium channels are found in most cases. Oral immunomodulatory therapy, intravenous immunoglobulin, and plasmapharesis may be entertained. Thymoma is found in approximately 50% of cases and thymectomy may be curative as in our particular case.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/cnd.0b013e31822b1977","type":"journal-article","created":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T11:50:46Z","timestamp":1337773846000},"page":"214-227","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":69,"title":["Morvan Syndrome"],"prefix":"10.1097","volume":"13","author":[{"given":"Elias","family":"Abou-Zeid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana Jeradeh","family":"Boursoulian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter S.","family":"Metzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"Gundogdu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20240808","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1196\/annals.1254.022","article-title":". Autoimmune disorders of neuronal potassium channels.","volume":"998","author":"Newsom-Davis","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"R2-6-20240808","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1093\/brain\/124.12.2417","article-title":". Morvans syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels.","volume":"124","author":"Liguori","year":"2001","journal-title":"Brain"},{"key":"R3-6-20240808","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10072-009-0041-y","article-title":". Course and outcome of a voltage-gated potassium channel antibody negative Morvans syndrome.","volume":"30","author":"Rinaldi","year":"2009","journal-title":"Neurol Sci"},{"key":"R4-6-20240808","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.clinimag.2007.03.007","article-title":". Radiology-Pathology Conference: pulmonary hyalinizing granuloma associated with lupus-like anticoagulant and Morvans Syndrome.","volume":"31","author":"Winger","year":"2007","journal-title":"Clin Imag"},{"key":"R5-6-20240808","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000090719","article-title":". fasciculations, autonomic symptoms and limbic encephalitis: a thymoma-associated Morvans-like syndrome.","volume":"54","author":"Deymeer","year":"2005","journal-title":"Eur Neurol"},{"key":"R6-6-20240808","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/00004691-200411000-00008","article-title":". Neurophysiologic studies in Morvan syndrome.","volume":"21","author":"Josephs","year":"2004","journal-title":"J Clin Neurophysiol"},{"key":"R7-6-20240808","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/ncpneuro0526","article-title":". Antibodies to AChR, MuSK and VGKC in a patient with myasthenia gravis and Morvans syndrome.","volume":"3","author":"Diaz-Manera","year":"2007","journal-title":"Nat Clin Pract Neurol"},{"key":"R8-6-20240808","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1749-6632.1998.tb10973.x","article-title":". Antibodies to AChR, synapse-organizing proteins, titin, and other muscle proteins in Morvans fibrillary chorea.","volume":"841","author":"Agius","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"R9-6-20240808","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1002\/art.1780291119","article-title":". Choree fibrillaire de Morvan followed by Guillain-Barre syndrome in a patient receiving gold therapy.","volume":"29","author":"Vernay","year":"1986","journal-title":"Arthritis Rheum"},{"key":"R10-6-20240808","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/BF01735061","article-title":". Concurrence of myasthenia gravis and choree fibrillaire de Morvan.","volume":"239","author":"Iwasaki","year":"1990","journal-title":"Eur Arch Psychiatry Neurol Sci"},{"key":"R11-6-20240808","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1136\/jnnp.2007.129882","article-title":". Functional imaging correlates of fronto-temporal dysfunction in Morvans syndrome.","volume":"79","author":"Toosy","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R12-6-20240808","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/0028-3886.30432","article-title":"An interesting case report of Morvans syndrome from the Indian subcontinent.","volume":"55","author":"Bajaj","year":"2007","journal-title":"Neurol India"},{"key":"R13-6-20240808","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0303-8467(89)80008-3","article-title":". Morvans fibrillary chorea. A case with possible manganese poisoning.","volume":"91","author":"Haug","year":"1989","journal-title":"Clin Neurol Neurosurg"},{"key":"R14-6-20240808","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1749-6632.1998.tb10969.x","article-title":". Morvans fibrillary chorea. Electrodiagnostic and in vitro microelectrode findings.","volume":"841","author":"Maselli","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"R15-6-20240808","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1136\/jnnp.65.6.857","article-title":". Morvans fibrillary chorea: a paraneoplastic manifestation of thymoma.","volume":"65","author":"Lee","year":"1998","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R16-6-20240808","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/BF00868410","article-title":". Morvans fibrillary chorea: remission after plasmapheresis.","volume":"243","author":"Madrid","year":"1996","journal-title":"J Neurol"},{"key":"R17-6-20240808","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1212\/WNL.54.3.771","article-title":"Morvans syndrome associated with voltage-gated K channel antibodies.","volume":"54","author":"Barber","year":"2000","journal-title":"Neurology"},{"key":"R18-6-20240808","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/mus.20081","article-title":". Morvans syndrome: clinical, laboratory, and in vitro electrophysiological studies.","volume":"30","author":"Loscher","year":"2004","journal-title":"Muscle Nerve"},{"key":"R19-6-20240808","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0960-8966(99)00046-2","article-title":". Multiple paraneoplastic diseases associated with thymoma.","volume":"9","author":"Evoli","year":"1999","journal-title":"Neuromuscul Disord"},{"key":"R20-6-20240808","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF00314093","article-title":"Neuromuscular, autonomic and central cholinergic hyperactivity associated with thymoma and acetylcholine receptor-binding antibody.","volume":"234","author":"Halbach","year":"1987","journal-title":"J Neurol"},{"key":"R21-6-20240808","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/brain\/awh077","article-title":". Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis.","volume":"127","author":"Vincent","year":"2004","journal-title":"Brain"},{"key":"R22-6-20240808","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jns.2007.09.030","article-title":". Reduplicative paramnesia in Morvans syndrome.","volume":"267","author":"Hudson","year":"2008","journal-title":"J Neurol Sci"},{"key":"R23-6-20240808","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1212\/01.WNL.0000156945.39471.2C","article-title":". Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia.","volume":"64","author":"Antozzi","year":"2005","journal-title":"Neurology"},{"key":"R24-6-20240808","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/j.1532-5415.2008.01621.x","article-title":"Sound-alike syndromes: first report of Morvans, and not Marfans, syndrome.","volume":"56","author":"Goldberg","year":"2008","journal-title":"J Am Geriatr Soc"},{"key":"R25-6-20240808","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1136\/jnnp.2003.031401","article-title":". Sub-acute presentation of Morvans syndrome after thymectomy.","volume":"75","author":"Cottrell","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R26-6-20240808","first-page":"65","article-title":". Voltage-gated potassium channel antibody-mediated syndromes: a spectrum of clinical manifestations.","volume":"5","author":"Rueff","year":"2008","journal-title":"Rev Neurol Dis"},{"key":"R27-6-20240808","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/ana.410380505","article-title":". Acquired neuromyotonia: evidence for autoantibodies directed against K channels of peripheral nerves.","volume":"38","author":"Shillito","year":"1995","journal-title":"Ann Neurol"},{"key":"R29-6-20240808","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1093\/brain\/awl084","article-title":". Neuromyotonia and limbic encephalitis sera target mature Shaker-type K channels: subunit specificity correlates with clinical manifestations.","volume":"129","author":"Kleopa","year":"2006","journal-title":"Brain"},{"key":"R30-6-20240808","first-page":"478","article-title":"Accidents nerveux de la chrysotherapie.","volume":"42","author":"Cavany","year":"1934","journal-title":"Presse Med"},{"key":"R31-6-20240808","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/brain\/103.3.671","article-title":". Clinical and morphological features of gold neuropathy.","volume":"103","author":"Katrak","year":"1980","journal-title":"Brain"},{"key":"R32-6-20240808","first-page":"852","article-title":"Motor unit irritability in beagles before and after exposure to cholinesterase inhibitors.","volume":"40","author":"Hazelwood","year":"1979","journal-title":"Am J Vet Res"},{"key":"R33-6-20240808","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11307-008-0134-7","article-title":"Role of FDG-PET in the clinical management of paraneoplastic neurological syndrome: detection of the underlying malignancy and the brain PET-MRI correlates.","volume":"10","author":"Basu","year":"2008","journal-title":"Mol Imaging Biol"},{"key":"R34-6-20240808","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1093\/brain\/awq213","article-title":". Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvans syndrome and acquired neuromyotonia.","volume":"133","author":"Irani","year":"2010","journal-title":"Brain"}],"container-title":["Journal of Clinical Neuromuscular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00131402-201206000-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T23:22:48Z","timestamp":1723159368000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00131402-201206000-00006"}},"subtitle":["A Case Report and Review of the Literature"],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/cnd.0b013e31822b1977","relation":{},"ISSN":["1522-0443"],"issn-type":[{"value":"1522-0443","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}