{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:36:50Z","timestamp":1791416210965,"version":"4.3.3"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>Myasthenia gravis is a nerve\u2013muscle junction disease, for which the most specific test is an increase in the anti-acetylcholine receptor antibodies (anti-AChR-Abs) titer. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting both upper and lower motor neurons. Positive AChR-Ab in patients with pure ALS are exceedingly rare. We report the case of a patient with confirmed ALS and very high levels of AChR-Ab and review the literature on this topic.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/cnd.0b013e31824db163","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T09:12:29Z","timestamp":1353489149000},"page":"82-85","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":25,"title":["Amyotrophic Lateral Sclerosis With Positive Anti-Acetylcholine Receptor Antibodies. Case Report and Review of the Literature"],"prefix":"10.1097","volume":"14","author":[{"given":"Raja","family":"Mehanna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie L.","family":"Patton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile L.","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadollah","family":"Harati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20240808","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1136\/jnnp.48.12.1246","article-title":"Acetylcholine receptor antibody as a diagnostic test for myasthenia gravis: results in 153 validated cases and 2967 diagnostic assays.","volume":"48","author":"Vincent","year":"1985","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R2-6-20240808","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/mus.21653","article-title":". Eliminating false-positive results in serum tests for neuromuscular autoimmunity.","volume":"41","author":"Apiwattanakul","year":"2010","journal-title":"Muscle Nerve"},{"key":"R3-6-20240808","first-page":"293","article-title":". El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis.","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler"},{"key":"R4-6-20240808","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1056\/NEJM198004103021519","article-title":"False-positive immunoassay for acetyl-choline receptor antibody in amyotrophic lateral sclerosis.","volume":"302","author":"Mittag","year":"1980","journal-title":"N Engl J Med"},{"key":"R5-6-20240808","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/(SICI)1097-4598(200002)23:2<294::AID-MUS25>3.0.CO;2-G","article-title":". ALS and myasthenia: an unusual association in a patient treated with riluzole.","volume":"23","author":"Restivo","year":"2000","journal-title":"Muscle Nerve"},{"key":"R6-6-20240808","doi-asserted-by":"crossref","first-page":"312","DOI":"10.2169\/internalmedicine.36.312","article-title":"T, Inoue H, et al.. Amyotrophic lateral sclerosis with anti-acetylcholine receptor antibody.","volume":"36","year":"1997","journal-title":"Int Med"},{"key":"R7-6-20240808","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3109\/17482960903452283","article-title":"Voltage gated potassium channel antibodies in amyotrophic lateral sclerosis.","volume":"11","author":"Nwosu","year":"2010","journal-title":"Amyotroph Lateral Scler"},{"key":"R8-6-20240808","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1073\/pnas.88.2.647","article-title":". 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Amyotrophic lateral sclerosis.","volume":"68","author":"Drachman","year":"1995","journal-title":"An autoimmune disease Adv Neurol"},{"key":"R12-6-20240808","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/ana.410400504","article-title":". Immunoassays fail to detect antibodies against neuronal calcium channels in amyotrophic lateral sclerosis serum.","volume":"40","author":"Arsac","year":"1996","journal-title":"Ann Neurol"},{"key":"R13-6-20240808","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/ana.410400505","article-title":"Proteolytic activity in amyotrophic lateral sclerosis IgG preparations.","volume":"40","author":"Nyormoi","year":"1996","journal-title":"Ann Neurol"},{"key":"R14-6-20240808","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/ana.410400502","article-title":"Amyotrophic lateral sclerosis and antibodies to voltage-gated calcium channelsnew doubts.","volume":"40","author":"Vincent","year":"1996","journal-title":"Ann Neurol"}],"container-title":["Journal of Clinical Neuromuscular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00131402-201212000-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T23:23:22Z","timestamp":1723159402000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00131402-201212000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/cnd.0b013e31824db163","relation":{},"ISSN":["1522-0443"],"issn-type":[{"value":"1522-0443","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}