{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T21:26:16Z","timestamp":1726435576820},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>Neurological complications of celiac disease (CD) include neuropathy, myeloneuropathy, and cerebellar degeneration. The cause of neuropathy in patients with CD is not known. Prior publications describe copper deficiency in CD patients with myeloneuropathy and neuropathy and posit that hypocupremia is the cause of these neurological conditions. However, based on our clinical experience, we hypothesized that CD patients with polyneuropathy are not deficient in copper.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Patients who met diagnostic criteria for CD and peripheral neuropathy were included. We reviewed the patient's records, including assessment of serum copper level and other clinical parameters.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Eighteen patients met inclusion criteria. Sixteen patients (89%) had normal copper levels, 2 had mild hypercupremia, and none had low copper levels. Of the 18 patients, 4 (22%) had large fiber neuropathy and 14 (78%) had a small fiber neuropathy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>No patient in this study showed hypocupremia. We are unable to demonstrate a relationship between our CD patients with Peripheral Neuropathy and copper deficiency.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/cnd.0b013e318260b455","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T07:35:08Z","timestamp":1345793708000},"page":"11-16","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Copper Levels in Patients With Celiac Neuropathy"],"prefix":"10.1097","volume":"14","author":[{"given":"Shanna K.","family":"Patterson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H. R.","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina A.","family":"Tennyson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne K.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Brannagan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-3-20240808","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMra071600","article-title":"Celiac disease.","volume":"357","author":"Green","year":"2007","journal-title":"N Engl J Med"},{"key":"R2-3-20240808","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1212\/01.wnl.0000325473.13088.18","article-title":". 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Micronutrient deficiencies in patients with typical and atypical celiac disease.","volume":"53","author":"Botero-Lopez","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"R5-3-20240808","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/MCG.0b013e3181354294","article-title":"Copper deficiency in celiac disease.","volume":"43","author":"Halfdanarson","year":"2009","journal-title":"J Clin Gastroenterol"},{"key":"R6-3-20240808","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/NRL.0b013e31819428a8","article-title":". Copper deficiency myeloneuropathy due to occult celiac disease.","volume":"15","author":"Goodman","year":"2009","journal-title":"Neurologist"},{"key":"R7-3-20240808","first-page":"1430","article-title":". Neurological complications of celiac disease: a rare but continuing problem.","volume":"91","author":"Muller","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"R8-3-20240808","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/MOG.0b013e32801421bb","article-title":"Copper deficiency.","volume":"23","author":"Madsen","year":"2007","journal-title":"Curr Opin Gastroenterol"},{"key":"R9-3-20240808","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1600-0609.2008.01050.x","article-title":". Hematological manifestations of copper deficiency: a retrospective review.","volume":"80","author":"Halfdanarson","year":"2008","journal-title":"Eur J Haematol"},{"key":"R10-3-20240808","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.4065\/81.10.1371","article-title":"Copper deficiency myelopathy: human swayback.","volume":"81","author":"Kumar","year":"2006","journal-title":"Mayo Clin Proc"},{"key":"R11-3-20240808","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.physbeh.2005.08.010","article-title":"Trace metal regulation of neuronal apoptosis: from genes to behavior.","volume":"86","author":"Levenson","year":"2005","journal-title":"Physiol Behav"},{"key":"R12-3-20240808","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1177\/0148607106030005446","article-title":"Severe ataxia, myelopathy, and peripheral neuropathy due to acquired copper deficiency in a patient with history of gastrectomy.","volume":"30","author":"Tan","year":"2006","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"R13-3-20240808","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/mus.21425","article-title":". Axonal sensory motor neuropathy in copper-deficient Wilsons disease.","volume":"40","author":"Foubert-Samier","year":"2009","journal-title":"Muscle Nerve"},{"key":"R14-3-20240808","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1023\/A:1021956200382","article-title":". Changing presentation of adult celiac disease.","volume":"48","author":"Lo","year":"2003","journal-title":"Dig Dis Sci"},{"key":"R16-3-20240808","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1002\/mus.1136","article-title":"Painful sensory polyneuropathy associated with impaired glucose tolerance.","volume":"24","author":"Singleton","year":"2001","journal-title":"Muscle Nerve"},{"key":"R17-3-20240808","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/mus.22074","article-title":"Modeling nerve conduction criteria for diagnosis of diabetic polyneuropathy.","volume":"44","author":"Dyck","year":"2011","journal-title":"Muscle Nerve"},{"key":"R18-3-20240808","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1001\/archneur.62.10.1574","article-title":"3rd, Hays AP, Chin SS, et al.. Small-fiber neuropathyneuronopathy associated with celiac disease: skin biopsy findings.","volume":"62","author":"Brannagan","year":"2005","journal-title":"Arch Neurol"},{"key":"R19-3-20240808","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1212\/01.WNL.0000063307.84039.C7","article-title":". Celiac neuropathy.","volume":"60","author":"Chin","year":"2003","journal-title":"Neurology"},{"key":"R20-3-20240808","first-page":"764","article-title":". A sex-linked recessive disorder with retardation of growth, peculiar hair, and focal cerebral and cerebellar degeneration.","volume":"29","author":"Menkes","year":"1962","journal-title":"Pediatrics"},{"key":"R21-3-20240808","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1365-2990.2006.00793.x","article-title":". Copper deficiency elicits glial and neuronal response typical of neurodegenerative disorders.","volume":"33","author":"Zucconi","year":"2007","journal-title":"Neuropathol Appl Neurobiol"},{"key":"R22-3-20240808","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0048-9697(85)90004-X","article-title":"Copper malabsoption in coeliac disease.","volume":"42","author":"Jameson","year":"1985","journal-title":"Sci Total Environ"}],"container-title":["Journal of Clinical Neuromuscular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00131402-201209000-00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T23:25:06Z","timestamp":1723159506000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00131402-201209000-00003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/cnd.0b013e318260b455","relation":{},"ISSN":["1522-0443"],"issn-type":[{"type":"print","value":"1522-0443"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}