{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:08:00Z","timestamp":1793322480618,"version":"4.5.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>Multicentric osteolysis nodulosis and arthropathy (MONA) syndrome is a rare autosomal recessive skeletal dysplasia. Caused by mutations in the matrix metalloproteinase 2 (<jats:italic toggle=\"yes\">MMP2<\/jats:italic>) gene on chromosome 16q12, this syndrome has infrequently been associated with ophthalmic manifestations. Corneal opacities have been reported but not described or documented in detail.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Complete ophthalmologic examination and multimodal anterior segment imaging were used to characterize the corneal findings in a patient with MONA syndrome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>A 19-year-old man with MONA syndrome was referred for an eye examination based on MONA screening recommendations. Visually insignificant peripheral corneal opacities were noted. Anterior segment optical coherence tomography demonstrated posterior stromal and endothelial hyperreflectivity. Confocal microscopy demonstrated an acellular peripheral endothelium with a normal central endothelium.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Corneal opacities can occur with MONA syndrome, which is caused by mutations in the <jats:italic toggle=\"yes\">MMP2<\/jats:italic> gene. In the patient presented here, the corneal opacities are peripheral, deep stromal, with sparing of the anterior stroma and epithelium.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/coa.0000000000000044","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T21:00:09Z","timestamp":1726520409000},"page":"e0044","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Multimodal Imaging of Posterior Corneal Opacities in Multicentric Osteolysis Nodulosis and Arthropathy"],"prefix":"10.1097","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7820-9136","authenticated-orcid":false,"given":"Sarah E.","family":"Eppley","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, California Pacific Medical Center, San Francisco, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neel D.","family":"Pasricha","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of California, San Francisco, San Francisco, CA;"},{"name":"Francis I. Proctor Foundation, University of California San Francisco, San Francisco, CA; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerami D.","family":"Seitzman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of California, San Francisco, San Francisco, CA;"},{"name":"Francis I. Proctor Foundation, University of California San Francisco, San Francisco, CA; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashlin","family":"Joye","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of California, San Francisco, San Francisco, CA;"},{"name":"Francis I. Proctor Foundation, University of California San Francisco, San Francisco, CA; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Arboleda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of California, San Francisco, San Francisco, CA;"},{"name":"Francis I. Proctor Foundation, University of California San Francisco, San Francisco, CA; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azam","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, California Pacific Medical Center, San Francisco, CA;"},{"name":"Benioff Children's Hospital Department of Pediatric Ophthalmology, University of California San Francisco, Oakland, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9]]},"reference":[{"key":"R1-20241016","first-page":"1993","article-title":"Multicentric osteolysis nodulosis and arthropathy","author":"Bhavani"},{"key":"R2-20241016","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/ajmg.a.37447","article-title":"Clinical and mutation profile of multicentric osteolysis nodulosis and arthropathy","volume":"170","author":"Bhavani","year":"2016","journal-title":"Am J Med Genet 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Ophthalmol."},{"key":"R13-20241016","doi-asserted-by":"crossref","first-page":"108500","DOI":"10.1016\/j.exer.2021.108500","article-title":"Matrix metalloproteinases and their inhibitors in Fuchs endothelial corneal dystrophy","volume":"205","author":"Xu","year":"2021","journal-title":"Exp Eye Res."}],"container-title":["Cornea 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