{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:03:40Z","timestamp":1793232220594,"version":"4.5.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1097\/coc.0b013e3181967dd0","type":"journal-article","created":{"date-parts":[[2009,11,27]],"date-time":"2009-11-27T20:33:53Z","timestamp":1259354033000},"page":"587-591","source":"Crossref","is-referenced-by-count":54,"title":["Radiation Treatment Interruptions Greater Than One Week and Low Hemoglobin Levels (12 g\/dL) are Predictors of Local Regional Failure After Definitive Concurrent Chemotherapy and Intensity-Modulated Radiation Therapy for Squamous Cell Carcinoma of the Head and Neck"],"prefix":"10.1097","volume":"32","author":[{"given":"Susan A.","family":"McCloskey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wainwright","family":"Jaggernauth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nestor R.","family":"Rigual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley L.","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurin R.","family":"Popat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry L.","family":"Mashtare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed K.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thom R.","family":"Loree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"suppl 3","key":"R1-6-20210128","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1634\/theoncologist.10-90003-11","article-title":"Paradigm shift in the treatment of head and neck cancer: the role of neoadjuvant chemotherapy.","volume":"10","author":"Posner","year":"2005","journal-title":"Oncologist"},{"key":"R2-6-20210128","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1200\/JCO.2004.08.021","article-title":"Final results of the 94\u201301 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma.","volume":"22","author":"Denis","year":"2004","journal-title":"J Clin Oncol"},{"key":"R3-6-20210128","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.ijrobp.2007.07.2380","article-title":"Locally advanced Stage IV squamous cell carcinoma of the head and neck: impact of pre-radiotherapy hemoglobin level and interruptions during radiotherapy.","volume":"70","author":"Rades","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R4-6-20210128","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0360-3016(02)04469-3","article-title":"Time factor in postoperative radiotherapy: a multivariate locoregional control analysis in 868 patients.","volume":"56","author":"Suwinski","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R5-6-20210128","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0167-8140(98)00038-3","article-title":"Effect of gap length and position on results of treatment of cancer of the larynx in Scotland by radiotherapy: a linear quadratic analysis.","volume":"48","author":"Robertson","year":"1998","journal-title":"Radiother Oncol"},{"key":"R6-6-20210128","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1259\/0007-1285-56-668-596","article-title":"The influence of the number of fractions, overall treatment time and field size on the local control of cancer of the skin.","volume":"56","author":"Hliniak","year":"1983","journal-title":"Br J Radiol"},{"key":"R7-6-20210128","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0360-3016(89)90503-8","article-title":"Dose fractionation and regeneration in radiotherapy for cancer of the oral cavity and oropharynx: tumor dose-response and repopulation.","volume":"16","author":"Maciejewski","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R8-6-20210128","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0360-3016(97)00716-5","article-title":"Similar decreases in local tumor control are calculated for treatment protraction and for interruptions in the radiotherapy of carcinoma of the larynx in four centers.","volume":"40","author":"Robertson","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R9-6-20210128","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0360-3016(97)00339-8","article-title":"The effect of interruptions and prolonged treatment time in radiotherapy for nasopharyngeal carcinoma.","volume":"39","author":"Kwong","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R10-6-20210128","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000415101","article-title":"Accelerated repopulation in head and neck cancer.","volume":"22","author":"Withers","year":"1988","journal-title":"Front Radiat Ther Oncol"},{"key":"R11-6-20210128","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ijrobp.2007.03.010","article-title":"Effects of prolongation of overall treatment time because of unplanned interruptions during radiotherapy of different tumor sites and practical methods for compensation.","volume":"68","author":"Bese","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R12-6-20210128","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1053\/clon.2002.0178","article-title":"An audit of delays before and during radical radiotherapy for cervical cancer\u2013effect on tumour cure probability.","volume":"15","author":"Coles","year":"2003","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"R13-6-20210128","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0169-5002(00)00240-3","article-title":"Using treatment interruptions to palliate the toxicity from concurrent chemoradiation for limited small cell lung cancer decreases survival and disease control.","volume":"33","author":"Videtic","year":"2001","journal-title":"Lung Cancer"},{"key":"R14-6-20210128","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0360-3016(01)01510-3","article-title":"The impact of gap duration on local control in anal canal carcinoma treated by split-course radiotherapy and concomitant chemotherapy.","volume":"50","author":"Weber","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R15-6-20210128","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000087909","article-title":"The effect of treatment interruptions in the postoperative irradiation of breast cancer.","volume":"69","author":"Bese","year":"2005","journal-title":"Oncology"},{"key":"R16-6-20210128","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0360-3016(98)00348-4","article-title":"Anemia is associated with decreased survival and increased locoregional failure in patients with locally advanced head and neck carcinoma: a secondary analysis of RTOG 85\u201327.","volume":"42","author":"Lee","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R17-6-20210128","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0167-8140(03)00198-1","article-title":"The effect of anaemia on efficacy and normal tissue toxicity following radiotherapy for locally advanced squamous cell carcinoma of the head and neck.","volume":"68","author":"Daly","year":"2003","journal-title":"Radiother Oncol"},{"key":"R18-6-20210128","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1200\/JCO.1995.13.8.2077","article-title":"Pretreatment hemoglobin level influences local control and survival of T1-T2 squamous cell carcinomas of the glottic larynx.","volume":"13","author":"Fein","year":"1995","journal-title":"J Clin Oncol"},{"key":"R19-6-20210128","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1148\/radiology.201.2.8888257","article-title":"Anemia is associated with lower local-regional control and survival after radiation therapy for head and neck cancer: a prospective study.","volume":"201","author":"Dubray","year":"1996","journal-title":"Radiology"},{"key":"R20-6-20210128","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0360-3016(98)00062-5","article-title":"T1\/T2 glottic cancer managed by external beam radiotherapy: the influence of pretreatment hemoglobin on local control.","volume":"41","author":"Warde","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R21-6-20210128","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00066-003-1117-x","article-title":"Hemoglobin as an independent prognostic factor in the radiotherapy of head and neck tumors.","volume":"179","author":"Schafer","year":"2003","journal-title":"Strahlenther Onkol"},{"key":"R22-6-20210128","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.clon.2003.09.009","article-title":"Influence of anaemia in patients with head and neck cancer receiving adjuvant postoperative radiotherapy in the Grampian region.","volume":"16","author":"Macdonald","year":"2004","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"R23-6-20210128","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0360-3016(97)00308-8","article-title":"Prognostic value of hemoglobin concentration in radiotherapy for cancer of supraglottic larynx.","volume":"38","author":"Tarnawski","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R24-6-20210128","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1002\/1097-0142(20010615)91:12<2214::AID-CNCR1251>3.0.CO;2-P","article-title":"Anemia as an independent prognostic factor for survival in patients with cancer: a systemic, quantitative review.","volume":"91","author":"Caro","year":"2001","journal-title":"Cancer"},{"key":"R25-6-20210128","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ijrobp.2005.04.049","article-title":"Anemia, tumor hypoxemia, and the cancer patient.","volume":"63","author":"Varlotto","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R26-6-20210128","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.ijrobp.2004.07.710","article-title":"Pretreatment anemia is correlated with the reduced effectiveness of radiation and concurrent chemotherapy in advanced head and neck cancer.","volume":"61","author":"Prosnitz","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R27-6-20210128","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S0140-6736(03)14567-9","article-title":"Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial.","volume":"362","author":"Henke","year":"2003","journal-title":"Lancet"},{"key":"R28-6-20210128","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.ijrobp.2007.04.063","article-title":"Radiotherapy with or without erythropoietin for anemic patients with head and neck cancer: a randomized trial of the Radiation Therapy Oncology Group (RTOG 99-03).","volume":"69","author":"Machtay","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R29-6-20210128","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJMoa053422","article-title":"Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck.","volume":"354","author":"Bonner","year":"2006","journal-title":"N Engl J Med"}],"container-title":["American Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/COC.0b013e3181967dd0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:09:40Z","timestamp":1786039780000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000421-200912000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/coc.0b013e3181967dd0","relation":{},"ISSN":["0277-3732"],"issn-type":[{"value":"0277-3732","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}