{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:21:00Z","timestamp":1790706060967,"version":"4.1.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1097\/coc.0b013e3182155fcb","type":"journal-article","created":{"date-parts":[[2011,3,29]],"date-time":"2011-03-29T02:00:35Z","timestamp":1301364035000},"page":"386-392","source":"Crossref","is-referenced-by-count":83,"title":["A Retrospective Study Evaluating Frequency and Risk Factors of Osteonecrosis of the Jaw in 576 Cancer Patients Receiving Intravenous Bisphosphonates"],"prefix":"10.1097","volume":"35","author":[{"given":"Vivek","family":"Thumbigere-Math","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lam","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Huckabay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkadiusz Z.","family":"Dudek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Lunos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Basi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph W.","family":"Leach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen K.","family":"Swenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajaram","family":"Gopalakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20210128","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1210\/edrv.19.1.0325","article-title":"Bisphosphonates: mechanisms of action.","volume":"19","author":"Fleisch","year":"1998","journal-title":"Endocr Rev"},{"key":"R2-15-20210128","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF02547227","article-title":"The binding of pyrophosphate and two diphosphonates by hydroxyapatite crystals.","volume":"11","author":"Jung","year":"1973","journal-title":"Calcif Tissue Res"},{"issue":"suppl 2","key":"R3-15-20210128","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1007\/PL00004164","article-title":"Bisphosphonates: pharmacology, mechanisms of action and clinical uses.","volume":"9","author":"Russell","year":"1999","journal-title":"Osteoporos Int"},{"key":"R4-15-20210128","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/BF02555852","article-title":"Inhibition of bone resorption by bisphosphonates: interactions between bisphosphonates, osteoclasts, and bone.","volume":"49","author":"Flanagan","year":"1991","journal-title":"Calcif Tissue Int"},{"key":"R7-15-20210128","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF00316291","article-title":"The effect of 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (ADP) on the resorptive function of osteoclasts of known nuclear number.","volume":"54","author":"Piper","year":"1994","journal-title":"Calcif Tissue Int"},{"key":"R8-15-20210128","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/jbmr.5650101008","article-title":"Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo.","volume":"10","author":"Hughes","year":"1995","journal-title":"J Bone Miner Res"},{"key":"R9-15-20210128","doi-asserted-by":"crossref","first-page":"34967","DOI":"10.1074\/jbc.274.49.34967","article-title":"Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis: a link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase.","volume":"274","author":"Reszka","year":"1999","journal-title":"J Biol Chem"},{"key":"R10-15-20210128","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1002\/1097-0142(20000615)88:12+<3080::AID-CNCR27>3.0.CO;2-W","article-title":"Bisphosphonates and the prevention of metastasis: first evidences from preclinical and clinical studies.","volume":"88","author":"Diel","year":"2000","journal-title":"Cancer"},{"key":"R11-15-20210128","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1054\/bjoc.1999.1131","article-title":"Bisphosphonates induce apoptosis in human breast cancer cell lines.","volume":"82","author":"Senaratne","year":"2000","journal-title":"Br J Cancer"},{"key":"R12-15-20210128","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/sj.leu.2401770","article-title":"Growth inhibition and synergistic induction of apoptosis by zoledronate and dexamethasone in human myeloma cell lines.","volume":"14","author":"Tassone","year":"2000","journal-title":"Leukemia"},{"key":"R13-15-20210128","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s002239900535","article-title":"The effect of alendronate on cytokine production, adhesion molecule expression, and transendothelial migration of human peripheral blood mononuclear cells.","volume":"63","author":"Pietschmann","year":"1998","journal-title":"Calcif Tissue Int"},{"key":"R14-15-20210128","first-page":"6538","article-title":"Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats.","volume":"62","author":"Fournier","year":"2002","journal-title":"Cancer Res"},{"key":"R15-15-20210128","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/01.cad.0000198909.52701.0f","article-title":"A new dimethyl ester bisphosphonate inhibits angiogenesis and growth of human epidermoid carcinoma xenograft in nude mice.","volume":"17","author":"Ledoux","year":"2006","journal-title":"Anticancer Drugs"},{"key":"R16-15-20210128","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8+<1652::AID-CNCR15>3.0.CO;2-Z","article-title":"Overview of bisphosphonates.","volume":"80","author":"Rogers","year":"1997","journal-title":"Cancer"},{"key":"R17-15-20210128","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/S0140-6736(96)07088-2","article-title":"Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures: Fracture Intervention Trial Research Group.","volume":"348","author":"Black","year":"1996","journal-title":"Lancet"},{"key":"R18-15-20210128","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1056\/NEJM199602223340802","article-title":"Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma: Myeloma Aredia Study Group.","volume":"334","author":"Berenson","year":"1996","journal-title":"N Engl J Med"},{"key":"R19-15-20210128","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1056\/NEJM199511303332201","article-title":"Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis: the Alendronate Phase III Osteoporosis Treatment Study Group.","volume":"333","author":"Liberman","year":"1995","journal-title":"N Engl J Med"},{"key":"R20-15-20210128","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1200\/JCO.2003.08.017","article-title":"American Society of Clinical Oncology 2003 update on the role of bisphosphonates and bone health issues in women with breast cancer.","volume":"21","author":"Hillner","year":"2003","journal-title":"J Clin Oncol"},{"key":"R21-15-20210128","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1200\/JCO.2002.06.037","article-title":"American Society of Clinical Oncology clinical practice guidelines: the role of bisphosphonates in multiple myeloma.","volume":"20","author":"Berenson","year":"2002","journal-title":"J Clin Oncol"},{"key":"R22-15-20210128","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.joms.2004.02.004","article-title":"Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases.","volume":"62","author":"Ruggiero","year":"2004","journal-title":"J Oral Maxillofac Surg"},{"key":"R23-15-20210128","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","article-title":"Bisphosphonate-induced exposed bone (osteonecrosisosteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment.","volume":"63","author":"Marx","year":"2005","journal-title":"J Oral Maxillofac Surg"},{"key":"R24-15-20210128","doi-asserted-by":"crossref","first-page":"8580","DOI":"10.1200\/JCO.2005.02.8670","article-title":"Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: incidence and risk factors.","volume":"23","author":"Bamias","year":"2005","journal-title":"J Clin Oncol"},{"key":"R25-15-20210128","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/ncponc0688","article-title":"Therapy insight: the risks and benefits of bisphosphonates for the treatment of tumor-induced bone disease.","volume":"4","author":"Dunstan","year":"2007","journal-title":"Nat Clin Pract Oncol"},{"key":"R26-15-20210128","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1359\/jbmr.080205","article-title":"Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates.","volume":"23","author":"Hoff","year":"2008","journal-title":"J Bone Miner Res"},{"key":"R27-15-20210128","doi-asserted-by":"crossref","first-page":"753","DOI":"10.7326\/0003-4819-144-10-200605160-00009","article-title":"Narrative corrected review: bisphosphonates and osteonecrosis of the jaws.","volume":"144","author":"Woo","year":"2006","journal-title":"Ann Intern Med"},{"key":"R29-15-20210128","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1016\/j.joms.2009.04.051","article-title":"Bisphosphonate-related osteonecrosis of the jaw: clinical features, risk factors, management, and treatment outcomes of 26 patients.","volume":"67","author":"Thumbigere-Math","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"R30-15-20210128","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1200\/JCO.2005.04.2465","article-title":"Osteonecrosis of the jaw in multiple myeloma patients: clinical features and risk factors.","volume":"24","author":"Badros","year":"2006","journal-title":"J Clin Oncol"},{"key":"R31-15-20210128","first-page":"968","article-title":"Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: evidence of increased risk after treatment with zoledronic acid.","volume":"91","author":"Dimopoulos","year":"2006","journal-title":"Haematologica"},{"key":"R32-15-20210128","doi-asserted-by":"crossref","first-page":"5356","DOI":"10.1200\/JCO.2009.21.9584","article-title":"Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw.","volume":"27","author":"Vahtsevanos","year":"2009","journal-title":"J Clin Oncol"},{"key":"R35-15-20210128","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1182\/blood-2006-07-033571","article-title":"Osteonecrosis of the jaws in newly diagnosed multiple myeloma patients treated with zoledronic acid and thalidomide-dexamethasone.","volume":"108","author":"Tosi","year":"2006","journal-title":"Blood"},{"key":"R36-15-20210128","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/10428190600977690","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: a review of 35 cases and an evaluation of its frequency in multiple myeloma patients.","volume":"48","author":"Pozzi","year":"2007","journal-title":"Leuk Lymphoma"},{"key":"R37-15-20210128","first-page":"637","article-title":"The incidence of osteonecrosis of the jaw (ONJ) in patients with multiple myeloma who receive biphosphonates depends on the type of biphosphonate.","volume":"106","author":"Dimopoulos","year":"2005","journal-title":"(American Society of Hematology Annual Meeting Abstracts)"},{"key":"R38-15-20210128","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.joms.2006.10.061","article-title":"Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia.","volume":"65","author":"Mavrokokki","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"R39-15-20210128","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1210\/jc.2006-2036","article-title":"Possible association between diabetes and bisphosphonate-related jaw osteonecrosis.","volume":"92","author":"Khamaisi","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"R40-15-20210128","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.joms.2007.11.032","article-title":"Zoledronate, smoking, and obesity are strong risk factors for osteonecrosis of the jaw: a case-control study.","volume":"66","author":"Wessel","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"R41-15-20210128","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s00198-005-1892-6","article-title":"Self-reported diseases and the risk of non-vertebral fractures: the Tromso study.","volume":"17","author":"Ahmed","year":"2006","journal-title":"Osteoporos Int"},{"key":"R42-15-20210128","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1089\/105072502760043503","article-title":"Fractures in patients with hyperthyroidism and hypothyroidism: a nationwide follow-up study in 16,249 patients.","volume":"12","author":"Vestergaard","year":"2002","journal-title":"Thyroid"},{"key":"R43-15-20210128","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00223-005-0068-x","article-title":"Influence of hyper- and hypothyroidism, and the effects of treatment with antithyroid drugs and levothyroxine on fracture risk.","volume":"77","author":"Vestergaard","year":"2005","journal-title":"Calcif Tissue Int"},{"key":"R44-15-20210128","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1902\/jop.2008.070466","article-title":"Thyroid hormones may influence cortical bone healing around titanium implants: a histometric study in rats.","volume":"79","author":"Feitosa Dda","year":"2008","journal-title":"J Periodontol"},{"key":"R45-15-20210128","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1272\/jnms.66.176","article-title":"The influence of hypothyroidism on wound healing: an experimental study.","volume":"66","author":"Natori","year":"1999","journal-title":"Nippon Ika Daigaku Zasshi"}],"container-title":["American Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00000421-201208000-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:57:28Z","timestamp":1786042648000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000421-201208000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/coc.0b013e3182155fcb","relation":{},"ISSN":["0277-3732"],"issn-type":[{"value":"0277-3732","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}