{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:37:35Z","timestamp":1755225455070,"version":"3.43.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>Heart failure (HF) is a complex clinical syndrome characterized by the heart\u2019s reduced capacity to meet the body\u2019s circulatory demands, frequently complicated by fluid overload. This accumulation of fluid contributes significantly to symptoms such as dyspnea, peripheral edema, and fatigue, and is driven by neurohormonal dysregulation involving the renin-angiotensin-aldosterone system and sympathetic nervous system. Fluid restriction has long been a cornerstone of HF management, intended to mitigate volume overload, improve symptoms, and prevent hospital readmissions. However, recent studies, including the FRESH-UP (Fluid REStriction in Heart failure vs Liberal Fluid UPtake) trial, suggest that strict fluid limitation may not yield substantial clinical benefits in stable HF patients and may negatively impact quality of life due to increased thirst and discomfort. Current guidelines recommend fluid restriction selectively, particularly for those with persistent congestion or hyponatremia unresponsive to standard therapy. Emerging evidence favors a more individualized approach to fluid management, considering patient-specific factors such as functional class, ejection fraction, symptom burden, and treatment response. Ongoing research is needed to refine these strategies, optimize patient outcomes, and enhance quality of life through more tailored fluid management protocols in HF care.<\/jats:p>","DOI":"10.1097\/crd.0000000000001007","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T12:01:07Z","timestamp":1755086467000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Fluid Restriction Versus No Restrictions in Heart Failure: A Comprehensive Analysis"],"prefix":"10.1097","author":[{"given":"Siddharth Pravin","family":"Agrawal","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, New York Medical College\/Landmark Medical Center, Woonsocket, RI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankti","family":"Maniyar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St Mary Medical Center, Langhorne, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya Nagesh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Neurology Department, University of Texas Medical Branch, Galveston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darshil Kumar","family":"Maheta","sequence":"additional","affiliation":[{"name":"Department of Public Health, New York Medical College, Valhalla, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"R9-20250813","doi-asserted-by":"crossref","first-page":"910100","DOI":"10.3389\/fcvm.2022.910100","article-title":"Biomarkers of volume overload and edema in heart failure with reduced ejection fraction.","volume":"9","author":"Chiorescu","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"R10-20250813","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.3390\/biomedicines11102684","article-title":"The 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