{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:42:58Z","timestamp":1770680578382,"version":"3.49.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Urinary tract infections (UTIs) are among the most common bacterial infections worldwide and have become more difficult to treat over the years. Inappropriate antibiotic use has led to increased antibiotic resistance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and methods:<\/jats:title>\n            <jats:p>We examined 1921 urine culture samples from a single hospital and analyzed them for bacterial spectrum and antibiotic susceptibility. We further analyzed changes in the rates of detected bacteria and of the sensitivity of these uropathogens to antibiotics over the years.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>In our hospital-based analysis, cystitis was the most frequently diagnosed UTI in women (76%) and men (79%). <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic> (48%) was the most commonly identified uropathogen. Samples demonstrated an increase in the proportion of <jats:italic toggle=\"yes\">E. coli (p<\/jats:italic>\u200a\n                                 <jats:italic toggle=\"yes\">&lt;<\/jats:italic>\u200a0.001) and a decrease in <jats:italic toggle=\"yes\">Enterococcus faecalis (p<\/jats:italic>\u200a\n                                 <jats:italic toggle=\"yes\">&lt;<\/jats:italic>\u200a0.001) over the study time period. Antimicrobial susceptibility analysis showed an increase over time in the number of isolates with resistance to ampicillin\/sulbactam <jats:italic toggle=\"yes\">(p<\/jats:italic>\u200a\n                                 <jats:italic toggle=\"yes\">&lt;<\/jats:italic>\u200a0.001) and to third-generation cephalosporins cefotaxime <jats:italic toggle=\"yes\">(p<\/jats:italic>\u200a\n                                 <jats:italic toggle=\"yes\">=<\/jats:italic>\u200a0.043) and ceftazidime <jats:italic toggle=\"yes\">(p<\/jats:italic>\u200a\n                                 <jats:italic toggle=\"yes\">&lt;<\/jats:italic>\u200a0.001).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Ampicillin\/sulbactam and third-generation cephalosporins are antibiotics frequently used in the treatment of UTIs. When selecting an optimal antimicrobial treatment regimen for patients with UTIs, it is imperative to understand regional and timedependent differences in the prevalence of various uropathogens and antimicrobial resistance patterns. Therefore, continuous surveillance of local pathogen and antimicrobial susceptibility patterns for frequently used antibiotics should be prioritized.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/cu9.0000000000000079","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T10:01:22Z","timestamp":1651744882000},"page":"94-98","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Decreasing susceptibility of bacteria to ampicillin\/ sulbactam and third generation cephalosporins in urinary tract infections"],"prefix":"10.1097","volume":"16","author":[{"given":"Stefan","family":"Vallo","sequence":"first","affiliation":[{"name":"Department of Urology, Hochtaunus-Kliniken, Bad Homburg, Germany"},{"name":"Urologie an der Zeil, Frankfurt am Main, Germany"},{"name":"Goethe University Frankfurt, Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Wirth","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hochtaunus-Kliniken, Bad Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Kukic","sequence":"additional","affiliation":[{"name":"Department of Hospital Hygiene, Hochtaunus-Kliniken, Bad Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Nafez","sequence":"additional","affiliation":[{"name":"Department of Urology, Hochtaunus-Kliniken, Bad Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ladislau","family":"Neagoe","sequence":"additional","affiliation":[{"name":"Department of Urology, Hochtaunus-Kliniken, Bad Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Nestler","sequence":"additional","affiliation":[{"name":"Department of Urology, Hochtaunus-Kliniken, Bad Homburg, Germany"},{"name":"UROGATE, Bad Vilbel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Urology, Hochtaunus-Kliniken, Bad Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"issue":"(3)","key":"R1-20250821","article-title":"Reaching the end of the line: Urinary tract infections","volume":"7","author":"Tamadonfar","year":"2019","journal-title":"Microbiol Spectr"},{"issue":"(3)","key":"R2-20250821","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0891-5520(05)70375-5","article-title":"Detection, significance, and therapy of bacteriuria in pregnancy. Update in the managed health care era","volume":"11","author":"Patterson","year":"1997","journal-title":"Infect Dis Clin North Am"},{"key":"R4-20250821","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jgar.2017.11.017","article-title":"Global research output in antimicrobial resistance among uropathogens: A bibliometric analysis (2002-2016)","volume":"13","author":"Sweileh","year":"2018","journal-title":"J Glob Antimicrob Resist"},{"issue":"(16)","key":"R5-20250821","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1001\/jama.2014.12842","article-title":"Diagnosis and management of urinary tract infections in the outpatient setting: A review","volume":"312","author":"Grigoryan","year":"2014","journal-title":"JAMA"},{"key":"R6-20250821","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4103\/ijpvm.IJPVM_419_17","article-title":"Pattern of antibacterial resistance in urinary tract infections: A systematic review and meta-analysis","volume":"10","author":"Mortazavi-Tabatabaei","year":"2019","journal-title":"Int J Prev Med"},{"issue":"(1)","key":"R7-20250821","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ucl.2007.09.004","article-title":"Uncomplicated urinary tract infection in adults including uncomplicated pyelonephritis","volume":"35","author":"Nicolle","year":"2008","journal-title":"Urol Clin North Am"},{"issue":"(Suppl 1)","key":"R8-20250821","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1016\/j.ijantimicag.2006.05.005","article-title":"Hospital acquired urinary tract infections in urology departments: Pathogens, susceptibility and use of antibiotics. 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