{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T07:14:53Z","timestamp":1694243693573},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n          <jats:p>Lymphomatoid papulosis (LyP) type E is a recently delineated variant characterized by the occurrence of large necrotic \u201ceschar\u201d-like lesions displaying microscopically angioinvasive and angiodestructive infiltrates composed of CD30<jats:sup>+<\/jats:sup> lymphocytes, frequently coexpressing CD8. In contrast to other LyP variants where patients develop multiple lesions, most patients with LyP type E present with few lesions (often 1 or 2 at a given time). In this article, we describe a 34-year-old man with LyP type E with an exacerbated clinical course characterized by the occurrence of almost a hundred of lesions. Initially, he presented with a single rapidly growing 2-cm large erythematous nodule on the forearm but after the administration of doxycycline multiple eschar-like lesions developed all over the body. Atypical lymphoid infiltrates with marked angiocentricity and angiotropism of CD30<jats:sup>+<\/jats:sup> medium-sized to large pleomorphic lymphocytes were seen histopathologically. After the withdrawal of the antibiotic, the lesions spontaneously regressed. Awareness of this rare LyP variant and its correct recognition, even if the clinical course is unusual and worrisome, is important to avoid aggressive treatment.<\/jats:p>","DOI":"10.1097\/dad.0000000000000970","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T22:57:14Z","timestamp":1505948234000},"page":"145-147","source":"Crossref","is-referenced-by-count":3,"title":["A Case of Lymphomatoid Papulosis Type E With an Unusual Exacerbated Clinical Course"],"prefix":"10.1097","volume":"40","author":[{"given":"Irena E.","family":"Belousova","sequence":"first","affiliation":[{"name":"Department of Dermatology, Medical Military Academy, Saint Petersburg, Russia; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liubov","family":"Kyrpychova","sequence":"additional","affiliation":[{"name":"Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey V.","family":"Samtsov","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical Military Academy, Saint Petersburg, Russia; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry V.","family":"Kazakov","sequence":"additional","affiliation":[{"name":"Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230908","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0733-8635(18)30869-6","article-title":"Lymphomatoid papulosis","volume":"3","author":"Willemze","year":"1985","journal-title":"Dermatol Clin."},{"key":"R2-20230908","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2133.1982.tb00331.x","article-title":"The clinical and histological spectrum of lymphomatoid papulosis","volume":"107","author":"Willemze","year":"1982","journal-title":"Br J Dermatol."},{"key":"R3-20230908","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.jaad.2012.12.952","article-title":"Follicular lymphomatoid papulosis revisited: a study of 11 cases, with new histopathological findings","volume":"68","author":"Kempf","year":"2013","journal-title":"J Am Acad Dermatol."},{"key":"R4-20230908","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1001\/archderm.140.4.441","article-title":"Lymphomatoid papulosis: reappraisal of clinicopathologic presentation and classification into subtypes A, B, and C","volume":"140","author":"El Shabrawi-Caelen","year":"2004","journal-title":"Arch Dermatol."},{"key":"R5-20230908","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/PAS.0b013e3182648596","article-title":"Angioinvasive lymphomatoid papulosis: a new variant simulating aggressive lymphomas","volume":"37","author":"Kempf","year":"2013","journal-title":"Am J Surg Pathol."},{"key":"R6-20230908","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1097\/DAD.0b013e3182943394","article-title":"Angioinvasive lymphomatoid papulosis: another case of a newly described variant","volume":"36","author":"Sharaf","year":"2014","journal-title":"Am J Dermatopathol."},{"key":"R7-20230908","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaad.2015.09.013","article-title":"Lymphomatoid papulosis: Treatment response and associated lymphomas in a study of 180 patients","volume":"74","author":"Wieser","year":"2016","journal-title":"J Am Acad Dermatol."},{"key":"R8-20230908","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/cup.12606","article-title":"New variant lymphomatoid papulosis type E preceding and coexisting with mycosis fungoides\u2014a case report and review of the literature","volume":"42","author":"Kiavash","year":"2015","journal-title":"J Cutan Pathol."},{"key":"R9-20230908","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s40257-016-0192-6","article-title":"Lymphomatoid papulosis in children and adolescents: a systematic review","volume":"17","author":"Wieser","year":"2016","journal-title":"Am J Clin Dermatol."},{"key":"R10-20230908","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1684\/ejd.2016.2831","article-title":"Angioinvasive lymphomatoid papulosis (type E): a first Japanese case","volume":"26","author":"Uchiyama","year":"2016","journal-title":"Eur J Dermatol."},{"key":"R11-20230908","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936","volume":"17","author":"van Dongen","year":"2003","journal-title":"Leukemia."}],"container-title":["The American Journal of Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00000372-201802000-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T05:14:24Z","timestamp":1694150064000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000372-201802000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1097\/dad.0000000000000970","relation":{},"ISSN":["0193-1091"],"issn-type":[{"value":"0193-1091","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}