{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T20:01:28Z","timestamp":1776024088489,"version":"3.50.1"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n          <jats:p>Lennert lymphoma is a lymphoepithelioid variant of peripheral T-cell lymphoma (not otherwise specified) with characteristics that do not fit into other peripheral T-cell lymphoma categories. Lennert lymphoma is primarily a nodal disease, and skin involvement may be exhibited. Cutaneous manifestations in Lennert lymphoma are nonspecific and include erythematous papules, nodules, and small plaques. Histological examination of cutaneous involvement characteristically presents epithelioid histiocytes and atypical small lymphocytes around vessels or appendages. A lymph node (LN) biopsy is essential for Lennert lymphoma diagnosis. In Lennert lymphoma, immunohistochemistry of both LNs and the involved skin reveals T-cell marker positivity. Although most Lennert lymphoma cases present with a single-positive CD4\/CD8 immunophenotype, few cases present with a double-positive CD4\/CD8 immunophenotype. We report a case of a 54-year-old woman presenting with fever, chills, general weakness, and a skin rash of erythematous patches on the trunk, extremities, and buttocks. A skin biopsy of the buttocks revealed atypical lymphocytes around the dermal vessels. In immunohistochemistry, these atypical lymphocytes stained positive for CD3, CD4, CD8, and CD68 but negative for CD20, CD30, and granzyme B. Similarly, a biopsy of the axillary LN revealed numerous epithelioid cells with atypical lymphocytes, exhibiting positivity for CD3, CD4, CD8, and CD68 but negativity for CD20, CD30, and S-100. Ki-67 was overexpressed in both the skin and LN. The final diagnosis of the patient was Lennert lymphoma with cutaneous involvement and a rare double-positive CD4\/CD8 immunophenotype. The patient was transferred to another hospital for chemotherapy as per her request.<\/jats:p>","DOI":"10.1097\/dad.0000000000002011","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T11:01:13Z","timestamp":1637751673000},"page":"121-125","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Rare Case of Double-Positive CD4\/CD8 Immunophenotype in Lennert Lymphoma With Cutaneous Involvement: A Case Report"],"prefix":"10.1097","volume":"44","author":[{"given":"Joong Ho","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Gaekhyeon-ri, Jeokseong-myeon, Paju-si, Gyeonggi-do, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji An","family":"Uh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myoung Shin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Un Ha","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"R1-20250616","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/CCO.0b013e3282ce6f8f","article-title":"Management of peripheral T-cell non-Hodgkin's lymphoma","volume":"19","author":"Horwitz","year":"2007","journal-title":"Curr Opin Oncol."},{"key":"R3-20250616","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2230.2004.01696.x","article-title":"Cutaneous presentation of recurrence of lymphoepithelioid T-cell lymphoma (Lennert's lymphoma)","volume":"30","author":"Massone","year":"2005","journal-title":"Clin Exp Dermatol."},{"key":"R4-20250616","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/j.1365-2559.2011.04069.x","article-title":"Revising the historical collection of epithelioid cell-rich lymphomas of the Kiel Lymph Node Registry: what is Lennert's lymphoma nowadays?","volume":"59","author":"Hartmann","year":"2011","journal-title":"Histopathology."},{"key":"R5-20250616","doi-asserted-by":"crossref","first-page":"248","DOI":"10.4103\/0377-4929.120379","article-title":"Lennert's lymphoma: clinicopathological profile of five cases","volume":"56","author":"Parimal","year":"2013","journal-title":"Indian J Pathol Microbiol."},{"key":"R6-20250616","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00428-004-1077-2","article-title":"Nodal peripheral T-cell lymphomas and, in particular, their lymphoepithelioid (Lennert's) variant are often derived from CD8(+) cytotoxic T-cells","volume":"445","author":"Geissinger","year":"2004","journal-title":"Virchows Arch."},{"key":"R7-20250616","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1097\/00000478-200012000-00006","article-title":"Lennert's lymphoma: a variant of cytotoxic T-cell lymphoma?","volume":"24","author":"Yamashita","year":"2000","journal-title":"Am J Surg Pathol."},{"key":"R8-20250616","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1097\/PAS.0000000000000694","article-title":"A clinicopathologic study of Lennert lymphoma and possible prognostic factors","volume":"40","author":"Kurita","year":"2016","journal-title":"Am J Surg Pathol."},{"issue":"suppl 1","key":"R9-20250616","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1600-0560.2008.01203.x","article-title":"Cutaneous involvement in the lymphoepithelioid variant of peripheral T-cell lymphoma, unspecified (Lennert lymphoma). Report of a case and review of the literature","volume":"36","author":"Summers","year":"2009","journal-title":"J Cutan Pathol."},{"key":"R10-20250616","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1182\/blood-2002-07-1960","article-title":"Peripheral T-cell lymphomas unspecified presenting in the skin: analysis of prognostic factors in a group of 82 patients","volume":"102","author":"Bekkenk","year":"2003","journal-title":"Blood."},{"key":"R11-20250616","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.critrevonc.2010.07.007","article-title":"Peripheral T-cell lymphoma\u2014not otherwise specified","volume":"79","author":"Savage","year":"2011","journal-title":"Crit Rev Oncol Hematol."},{"key":"R12-20250616","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1182\/blood.V68.3.663.663","article-title":"Lymphoepithelioid lymphoma (Lennert's lymphoma) is a monoclonal proliferation of helper\/inducer T cells","volume":"68","author":"Feller","year":"1986","journal-title":"Blood."},{"key":"R13-20250616","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1440-1827.2005.01880.x","article-title":"Aggressive Lennert's lymphoma: report of three cases in comparison to non-aggressive Lennert's lymphoma","volume":"10","author":"Kitamura","year":"2005","journal-title":"Pathol Int."},{"key":"R14-20250616","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/ajcp\/91.2.152","article-title":"Immunohistochemical analysis of peripheral T-cell lymphoma in Japanese patients","volume":"91","author":"Doi","year":"1989","journal-title":"Am J Clin Pathol."}],"container-title":["The American Journal of Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/DAD.0000000000002011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T19:03:03Z","timestamp":1750100583000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/DAD.0000000000002011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1097\/dad.0000000000002011","relation":{},"ISSN":["0193-1091"],"issn-type":[{"value":"0193-1091","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11,23]]}}}