{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:15:03Z","timestamp":1778796903398,"version":"3.51.4"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n            <jats:title>Introduction:<\/jats:title>\n            <jats:p>Primary cutaneous marginal zone B-cell lymphoma (MZL) follows an indolent clinical course. Histopathologically, there is a polymorphous infiltrate that includes small lymphocyte-like and centrocyte-like B cells and plasma cells usually with a substantial T-cell fraction. Primary cutaneous CD4<jats:sup>+<\/jats:sup> small\/medium T-cell lymphoproliferative disorder, in which the signature cells have a follicular T-helper (TFH) phenotype and are admixed with numerous B cells. Thus, both present histologies of combined B-cell and T-cell infiltrates and represent differential diagnoses. The presence of TFH in MZL has yet to be elucidated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Forty-one biopsies from 40 cases of MZL and 7 cases of lymphoid hyperplasia cutis (LCH) were stained with antibodies to follicular T-helper cells, including Bcl-6, PD-1, ICOS, and CD10, as part of their diagnostic workup, were reviewed, and the stained slides were evaluated semiquantitively. Five reactive lymph nodes were also evaluated as controls.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>All cases of MZL and LCH contained TFH, albeit usually in low proportions. There were repeated differences in levels of expression between TFH markers, with PD1 and Bcl-6 being the most prevalent. The pattern of involvement in MZL and LCH closely mirrored that observed in the reactive lymph nodes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>MZL includes TFH cells, similar to reactive lymph nodes, and a complexity of cell types. This provides evidence of an organoid immune response challenging its simple categorization as a malignancy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/dad.0000000000002017","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T11:22:38Z","timestamp":1625656958000},"page":"e197-e203","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Follicular T-Helper Cells in Marginal Zone Lymphoma: Evidence of an Organoid Immune Response"],"prefix":"10.1097","volume":"43","author":[{"given":"Alistair","family":"Robson","sequence":"first","affiliation":[{"name":"London Digital Pathology, UK, and IPOLFG, Servi\u00e7o de Anatomia Patol\u00f3gica, Lisboa, Portugal;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2753-8586","authenticated-orcid":false,"given":"Farrah","family":"Bakr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellie","family":"Rashidghamat","sequence":"additional","affiliation":[{"name":"Department of Dermatology, St John's Institute of Dermatology, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zena N.","family":"Willsmore","sequence":"additional","affiliation":[{"name":"Department of Dermatology, St John's Institute of Dermatology, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Ally","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Stanford University, Stanford, CA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Greenblatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Barlow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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