{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:21:51Z","timestamp":1773012111269,"version":"3.50.1"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Frontal fibrosing alopecia (FFA) is a scarring alopecia that affects the frontotemporal hairline. Clinically, it may develop with cutaneous hypopigmentation of the affected areas, which has been associated with a reduction in the epidermal melanocyte count. In trichoscopy, peripilar white halos can be observed, which have been associated with fibrosis in other scarring alopecias.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>To evaluate the trichoscopic, histopathological and immunohistochemical characteristics of the peripilar white halos in FFA patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and methods:<\/jats:title>\n            <jats:p>We conducted a descriptive cross-sectional study that included 12 patients with FFA presenting peripilar white halos. Two 2-mm punch trichoscopy-guided biopsies were performed in all patients, one fragment for vertical section and another for horizontal section. The vertical sections were stained with Fontana-Mason and Melan-A.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>On trichoscopic examination, peripilar white halos \u2264 1 mm in size were observed on the affected scalp. In vertical sections, a reduction in basal melanin pigmentation and a decrease in the melanocyte count in the upper segment of the hair follicle were observed with Fontana-Masson staining and Melan-A immunostaining, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Limitations:<\/jats:title>\n            <jats:p>The small sample size and absence of a control group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>This study shows follicular melanocyte involvement in FFA, and this finding may be associated with the peripilar white halos observed in trichoscopy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/dad.0000000000002115","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T08:28:15Z","timestamp":1640852895000},"page":"254-256","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Follicular Melanocytes in Frontal Fibrosing Alopecia: An Immunohistochemical Study With Trichoscopic Correlation"],"prefix":"10.1097","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9077-0433","authenticated-orcid":false,"given":"Corina Isabel","family":"Salas-Callo","sequence":"first","affiliation":[{"name":"Department of Dermatology, Instituto de Dermatologia Professor Rubem David Azulay, Hospital da Santa Casa da Miseric\u00f3rdia do Rio de Janeiro, RJ, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Carvalho Quintella","sequence":"additional","affiliation":[{"name":"Department of Pathology, Federal University of Rio de Janeiro, RJ, Brazil; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Saceda-Corralo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ramon y Cajal University Hospital, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Pirmez","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Instituto de Dermatologia Professor Rubem David Azulay, Hospital da Santa Casa da Miseric\u00f3rdia do Rio de Janeiro, RJ, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2021,12,28]]},"reference":[{"key":"R1-20250616","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s40257-019-00424-y","article-title":"Frontal fibrosing alopecia: an update on pathogenesis, diagnosis, and treatment","volume":"20","author":"Iorizzo","year":"2019","journal-title":"Am J Clin Dermatol"},{"key":"R2-20250616","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.jaad.2017.01.001","article-title":"Hypopigmentation in frontal fibrosing alopecia","volume":"76","author":"Lin","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"R3-20250616","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000512866","article-title":"Hypopigmentation of the eyebrows in frontal fibrosing alopecia","volume":"7","author":"Salas-Callo","year":"2021","journal-title":"Skin Appendage Disord"},{"key":"R4-20250616","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jaad.2014.04.069","article-title":"Dermatoscopic features of central centrifugal cicatricial alopecia","volume":"71","author":"Miteva","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"R5-20250616","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/cup.13467","article-title":"Histopathology of aging of the hair follicle","volume":"46","author":"Fernandez-Flores","year":"2019","journal-title":"J Cutan Pathol"},{"key":"R6-20250616","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000489794","article-title":"Peripilar \u201fguttate\u201d hypopigmentation of the scalp and idiopathic guttate hypomelanosis in frontal fibrosing alopecia","volume":"5","author":"Diaz","year":"2019","journal-title":"Skin Appendage Disord"}],"container-title":["The American Journal of Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/DAD.0000000000002115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T19:01:25Z","timestamp":1750100485000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/DAD.0000000000002115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,28]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1097\/dad.0000000000002115","relation":{},"ISSN":["0193-1091"],"issn-type":[{"value":"0193-1091","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12,28]]}}}