{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:38:02Z","timestamp":1792132682615,"version":"4.4.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:p>BAP1-inactivated melanocytic tumor (BIMT) represents a distinct subtype of melanocytoma, with characteristic morphologic features. These lesions are associated with inactivation of the BAP1 tumor suppressor gene. Although there are frequently histologic features that might otherwise cause concern for malignancy, including enlarged cells with nuclear variability, prominent nucleoli, and a lymphocytic inflammatory infiltrate, empirical data suggest that the majority behave in a clinically benign fashion. We report 2 cases of cutaneous BIMT with a distinctive morphologic pattern of clonal expansion with p16 loss. In both cases, there was liver metastasis after complete excision, in the absence of locoregional recurrence. These rare cases highlight the possibility of a distinct pathway of malignant progression in BIMT.<\/jats:p>","DOI":"10.1097\/dad.0000000000003151","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T23:00:09Z","timestamp":1763161209000},"page":"114-117","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["BAP1-Inactivated Melanocytic Tumors With Distinctive p16-Negative Clonal Growth and Liver Metastases"],"prefix":"10.1097","volume":"48","author":[{"given":"Benjamin A.","family":"Wood","sequence":"first","affiliation":[{"name":"PathWest Laboratory Medicine, J Block, QEII Medical Centre, Perth, Western Australia, Australia;"},{"name":"The University of Western Australia, Perth, Western Australia, Australia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Shepard","sequence":"additional","affiliation":[{"name":"ClinPath Pathology, Adelaide, South Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"James","sequence":"additional","affiliation":[{"name":"ClinPath Pathology, Adelaide, South Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan T.","family":"Harvey","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine, J Block, QEII Medical Centre, Perth, Western Australia, Australia;"},{"name":"The University of Western Australia, Perth, Western Australia, Australia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Mesbah Ardakani","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine, J Block, QEII Medical Centre, Perth, Western Australia, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"R1-20260127","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/ng.910","article-title":"Germline mutations in BAP1 predispose to melanocytic tumors","volume":"43","author":"Wiesner","year":"2011","journal-title":"Nat Genet"},{"key":"R2-20260127","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.pathol.2016.11.008","article-title":"Detection of copy number variations in melanocytic lesions utilising array based comparative genomic hybridisation","volume":"49","author":"Mesbah Ardakani","year":"2017","journal-title":"Pathology"},{"key":"R3-20260127","article-title":"BAP-1 inactivated melanocytoma in WHO classification of tumours editorial board. Skin tumours [Internet; beta version ahead of print]","author":"Wiesner","year":"2023","journal-title":"Int Agency Res Cancer"},{"key":"R4-20260127","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.jaad.2018.09.014","article-title":"Clinical and dermoscopic features of cutaneous BAP1-inactivated melanocytic tumors: results of a multicenter case-control study by the International Dermoscopy Society","volume":"80","author":"Y\u00e9lamos","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"R5-20260127","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/s41379-021-00976-7","article-title":"Novel insights into the BAP1-inactivated melanocytic tumor","volume":"35","author":"Donati","year":"2022","journal-title":"Mod Pathol"},{"key":"R6-20260127","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/PAS.0b013e3182498be5","article-title":"A distinct subset of atypical Spitz tumors is characterized by BRAF mutation and loss of BAP1 expression","volume":"36","author":"Wiesner","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"R7-20260127","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1097\/DAD.0000000000001719","article-title":"Histologically diverse BAP1-deficient melanocytic tumors in a patient with BAP1 tumor predisposition syndrome","volume":"42","author":"Louw","year":"2020","journal-title":"Am J Dermatopathol"},{"key":"R8-20260127","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.jaad.2018.05.005","article-title":"Histomorphologic spectrum of germline-related and sporadic BAP1-inactivated melanocytic tumors","volume":"79","author":"Garfield","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"R9-20260127","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/PAT.0000000000000337","article-title":"BAP1 deficient malignant melanoma arising from the intradermal component of a congenital melanocytic naevus","volume":"47","author":"Ardakani","year":"2015","journal-title":"Pathology"},{"key":"R10-20260127","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/DAD.0000000000001217","article-title":"Melanoma with loss of BAP1 expression in patients with No family history of BAP1-associated cancer susceptibility syndrome: a case series","volume":"41","author":"Aung","year":"2019","journal-title":"Am J Dermatopathol"},{"key":"R11-20260127","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/DAD.0000000000002332","article-title":"BAP1-Inactivated melanoma arising from BAP1-inactivated melanocytic tumor in a patient with BAP1 germline mutation: a case report and review of the literature","volume":"45","author":"Donati","year":"2023","journal-title":"Am J Dermatopathol"},{"issue":"suppl 1","key":"R12-20260127","doi-asserted-by":"crossref","first-page":"i112","DOI":"10.1093\/bjd\/ljae090.235","article-title":"DP13 First case of distant metastases from a BAP1-inactivated melanocytoma with melanoma transformation","volume":"191","author":"Guckian","year":"2024","journal-title":"Br J Dermatol"},{"key":"R13-20260127","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/PAT.0b013e3283653818","article-title":"BAP1 expression in cutaneous melanoma: a pilot study","volume":"45","author":"Murali","year":"2013","journal-title":"Pathology"}],"container-title":["The American Journal of Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/DAD.0000000000003151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:00:16Z","timestamp":1769551216000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/DAD.0000000000003151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1097\/dad.0000000000003151","relation":{},"ISSN":["0193-1091","1533-0311"],"issn-type":[{"value":"0193-1091","type":"print"},{"value":"1533-0311","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,14]]}}}