{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:30:28Z","timestamp":1790447428999,"version":"4.1.0"},"reference-count":64,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2014,2,1]]},"abstract":"<jats:p>Although adoption of skin sensitization in vivo assays for hazard identification is likely to be successful in the next few years, this does not replace their use in potency prediction. Notably, measurement of potency of skin sensitizers in the local lymph node assay has been important. However, this local lymph node assay potency measure has not been formally assessed against a range of substances of known human sensitizing potential, because the latter is lacking. Accordingly, criteria for human data have been established that characterize 6 categories of human sensitizing potency, with 1 the most potent and 5 the least potent; category 6 represents true nonsensitizers. The literature has been searched, and 131 chemicals assigned into these categories according to their intrinsic potency judged only by the available human information. The criteria and data set generated provide a basis for examination of the capacity of nonanimal approaches for the determination of human sensitization potency.<\/jats:p>","DOI":"10.1097\/der.0000000000000003","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T12:01:38Z","timestamp":1397649698000},"page":"11-21","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":185,"title":["Categorization of Chemicals According to Their Relative Human Skin Sensitizing Potency"],"prefix":"10.1177","volume":"25","author":[{"given":"David A.","family":"Basketter","sequence":"first","affiliation":[{"name":"From the *DABMEB Consultancy Ltd, Sharnbrook, Bedford, UK;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Al\u00e9p\u00e9e","sequence":"additional","affiliation":[{"name":"L\u2019Or\u00e9al Research &amp; Innovation, Aulnay Sous Bois, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Ashikaga","sequence":"additional","affiliation":[{"name":"Shiseido Co, Ltd, Quality Assurance Center, Kanagawa, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Barroso","sequence":"additional","affiliation":[{"name":"Cosmetics Europe, The Personal Care Association, Brussels, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Gilmour","sequence":"additional","affiliation":[{"name":"Unilever, Safety and Environmental Assurance Centre, Bedford, Sharnbrook, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Goebel","sequence":"additional","affiliation":[{"name":"The Procter &amp; Gamble Company, Darmstadt, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalila","family":"Hibatallah","sequence":"additional","affiliation":[{"name":"Chanel, Neuilly sur Seine, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Seh Consulting + Services, Paderborn, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Kern","sequence":"additional","affiliation":[{"name":"The Procter &amp; Gamble Company, Strombeek Bever, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Martinozzi-Teissier","sequence":"additional","affiliation":[{"name":"L\u2019Or\u00e9al Research &amp; Innovation, Aulnay Sous Bois, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Unilever, Safety and Environmental Assurance Centre, Bedford, Sharnbrook, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Reisinger","sequence":"additional","affiliation":[{"name":"Henkel AG &amp; Co KGaA, D\u00fcsseldorf, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Kao Corporation, Safety Science Research Laboratories, Tochigi, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schepky","sequence":"additional","affiliation":[{"name":"Beiersdorf, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magalie","family":"Tailhardat","sequence":"additional","affiliation":[{"name":"LVMH Recherche, St Jean De Braye Cedex, Castres, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Templier","sequence":"additional","affiliation":[{"name":"Laboratoire Pierre Fabre, Castres, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,2,1]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/59.2.198"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03827-3_13"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-011-0693-2"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1586\/17469872.2.4.471"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/026119290803600511"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.14573\/altex.2011.1.050"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0846-8"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2012.692135"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/026119290903700313"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/026119290803600211"},{"key":"e_1_3_1_12_2","unstructured":"United Nations. Globally Harmonized System of Classification and Labelling of Chemicals (GHS). Part 3: Health Hazards 2011. Available at: http:\/\/www.unece.org\/fileadmin\/DAM\/trans\/danger\/publi\/ghs\/ghs_rev04\/English\/03e_part3.pdf. Accessed September16 2013."},{"issue":"2","key":"e_1_3_1_13_2","first-page":"24","article-title":"ECVAM: progressing skin sensitization alternatives for hazard identification","volume":"66","author":"Basketter D","year":"2012","unstructured":"Basketter D, , Angers-Loustau A, , Casati S, et al. ECVAM: progressing skin sensitization alternatives for hazard identification. Contact Dermatitis, 2012; 66 (suppl 2): 24.","journal-title":"Contact Dermatitis"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2012.06.003"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000411607"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/10629369408029901"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01206501-200512000-00002"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2009.09038"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(03)00266-X"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1263(199907\/08)19:4<261::AID-JAT572>3.0.CO;2-5"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01141.x"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2000.042006344.x"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2000.043002095.x"},{"key":"e_1_3_1_24_2","first-page":"156","article-title":"Contact allergenic potency: Correlation of human and local lymph node assay data","volume":"12","author":"Gerberick GF","year":"2001","unstructured":"Gerberick GF, , Robinson MK, , Ryan CA, et al. Contact allergenic potency: Correlation of human and local lymph node assay data. Am J Contact Dermatitis, 2001; 12: 156\u2013161.","journal-title":"Am J Contact Dermatitis"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2003.07.001"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2004.02.002"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00707.x"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2007.10.008"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn204"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01952.x"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2007.11.008"},{"key":"e_1_3_1_32_2","unstructured":"ICCVAM 2011. Test Method Evaluation Report: Usefulness and limitations of the murine local lymph node assay for potency categorization of chemicals causing allergic contact dermatitis in humans. NJI publication 11-7709. Available at: http:\/\/iccvam.niehs.nih.gov\/docs\/immunotox_docs\/LLNA-pot\/TMER.pdf. Accessed June26 2012."},{"key":"e_1_3_1_33_2","unstructured":"Cronin E. Contact Dermatitis. Edinburgh: Churchill Livingstone;. 1980."},{"key":"e_1_3_1_34_2","unstructured":"Rietschel RL Fowler JF. Fisher\u2019s Contact Dermatitis. 6th ed. Hamilton: BC Decker;. 2008."},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03827-3"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1080\/15569520902938032"},{"key":"e_1_3_1_37_2","first-page":"393","article-title":"The identification of contact allergens by human assay","volume":"7","author":"Kligman AM.","year":"1966","unstructured":"Kligman AM. The identification of contact allergens by human assay. III. The maximization test: a procedure for screening and rating contact sensitizers. J Invest Dermatol, 1966; 7: 393\u2013409.","journal-title":"III. The maximization test: a procedure for screening and rating contact sensitizers. J Invest Dermatol"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0015-6264(74)90367-8"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1976.tb03069.x"},{"key":"e_1_3_1_40_2","first-page":"399","article-title":"Antimicrobials: experimental contact sensitization in man","volume":"24","author":"Marzulli FN","year":"1973","unstructured":"Marzulli FN, , Maibach HI. Antimicrobials: experimental contact sensitization in man. J Soc Cosmet Chem, 1973; 24: 399\u2013421.","journal-title":"J Soc Cosmet Chem"},{"key":"e_1_3_1_41_2","first-page":"235","article-title":"Contact allergy: predictive testing of fragrance ingredients in humans by Draize and maximization methods","volume":"3","author":"Marzulli FN","year":"1980","unstructured":"Marzulli FN, , Maibach HI. Contact allergy: predictive testing of fragrance ingredients in humans by Draize and maximization methods. J Environ Path Toxic, 1980; 3: 235\u2013245.","journal-title":"J Environ Path Toxic"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1980.tb03921.x"},{"key":"e_1_3_1_43_2","unstructured":"Scientific Committee on Consumer Safety (SCCS). Opinion on fragrance allergens in cosmetic products. 2011. SCCS\/1459\/1 December 13-14 2011. Available at: http:\/\/ec.europa.eu\/health\/scientific_committees\/consumer_safety\/docs\/sccs_o_102.pdf. Accessed September16 2013."},{"key":"e_1_3_1_44_2","first-page":"103","article-title":"Cutaneous allergies","author":"Basketter DA","year":"2012","unstructured":"Basketter DA, , McFadden JP. Cutaneous allergies. In: Dietert R, Luebke R, eds. Immunotoxicity, Immune Dysfunction and Chronic Disease. New York: Springer;, 2012; 103\u2013126.","journal-title":"In: Dietert R, Luebke R, eds. Immunotoxicity, Immune Dysfunction and Chronic Disease. New York: Springer;"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06030.x"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02079.x"},{"key":"e_1_3_1_47_2","volume-title":"Allergic Contact Dermatitis and Metabolic Mechanisms","author":"Smith CM","year":"2001","unstructured":"Smith CM, , Hotchkiss SAM. Allergic Contact Dermatitis and Metabolic Mechanisms. London, UK: Taylor and Francis; 2001."},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01486.x"},{"key":"e_1_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01478.x"},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2009.04.001"},{"key":"e_1_3_1_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70051-1"},{"key":"e_1_3_1_52_2","first-page":"276","article-title":"Frequency of sensitization to 13 common preservatives in Switzerland","volume":"30","author":"Perrenoud D","year":"1994","unstructured":"Perrenoud D, , Bircher A, , Hunziker T. Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group. Contact Dermatitis, 1994; 30: 276\u2013279.","journal-title":"Swiss Contact Dermatitis Research Group. Contact Dermatitis"},{"key":"e_1_3_1_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02846.x"},{"key":"e_1_3_1_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01283.x"},{"key":"e_1_3_1_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01953.x"},{"key":"e_1_3_1_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01904.x"},{"key":"e_1_3_1_57_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina47090072"},{"key":"e_1_3_1_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03827-3_34"},{"key":"e_1_3_1_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01936.x"},{"key":"e_1_3_1_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00693.x"},{"key":"e_1_3_1_61_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx700024w"},{"key":"e_1_3_1_62_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx700338q"},{"key":"e_1_3_1_63_2","first-page":"30","article-title":"The use of human data when conducting dermal sensitization quantitative risk assessments for fragrance ingredients; how well does the LLNA predict human NOELs?","volume":"108","author":"Api A M","year":"2009","unstructured":"Api A M, , Lalko J, , Politano VT. The use of human data when conducting dermal sensitization quantitative risk assessments for fragrance ingredients; how well does the LLNA predict human NOELs?. Toxicologist, 2009; 108: 30\u201332.","journal-title":"Toxicologist"},{"key":"e_1_3_1_64_2","unstructured":"ICCVAM. Recommended Performance Standards: Murine Local Lymph Node Assay. NIH Publication 09-7357. Research Triangle Park NC: National Institute of Environmental Health Sciences; 2009. Available at: http:\/\/iccvam.niehs.nih.gov\/methods\/immunotox\/llna_PerfStds.htm. Accessed July30 2012."},{"key":"e_1_3_1_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12007"}],"container-title":["Dermatitis\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1097\/DER.0000000000000003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1097\/DER.0000000000000003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1097\/DER.0000000000000003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:08:14Z","timestamp":1777399694000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1097\/DER.0000000000000003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,1]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2,1]]}},"alternative-id":["10.1097\/DER.0000000000000003"],"URL":"https:\/\/doi.org\/10.1097\/der.0000000000000003","relation":{},"ISSN":["1710-3568","2162-5220"],"issn-type":[{"value":"1710-3568","type":"print"},{"value":"2162-5220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,1]]}}}