{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:26:34Z","timestamp":1790659594678,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2014,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Excipients in various formulations of active drugs occasionally include known contact allergens. Their ingestion may trigger dermatitis or cause it to become widespread or refractory to therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the prevalence of common contact allergens among the excipients of oral antihistamines available in this country.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We gathered the complete ingredient lists of 2119 different preparations of 12 oral antihistamines from the National Library of Medicine data bank and entered them into an electronic database for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>More than half the formulations (55.0%) contained at least 1 member of the 10 allergen families assessed. Most brompheniramine and doxepin preparations included potentially allergenic excipients, whereas fexofenadine was most often free of them. Sorbitan group members, azo dyes, and propylene glycol were the allergens found most frequently in the antihistamines, each present in over 25% of the products. Elixirs, liquids, solutions, suspensions, and syrups were more likely than nonchewable caplets, capsules, and tablets to contain the allergens tabulated (100% vs 39.3%, respectively). Chewable pills frequently contained azo dyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ingestion of antihistamines could precipitate a systemic contact dermatitis in a patient sensitized to an allergen present as an excipient in the medicine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/der.0000000000000028","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T12:01:15Z","timestamp":1397649675000},"page":"83-88","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Contact Allergens in Oral Antihistamines"],"prefix":"10.1177","volume":"25","author":[{"given":"Melissa","family":"McEnery-Stonelake","sequence":"first","affiliation":[{"name":"From the *University of Massachusetts Medical School;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne L.","family":"Silvestri","sequence":"additional","affiliation":[{"name":"UMass Memorial Medical Center, Worcester, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,4,1]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2009.05.005"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e31827658ed"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e318281d87b"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e31828afab2"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2008.08006"},{"issue":"2","key":"e_1_3_1_7_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.0105-1873.2006.00773.x","article-title":"Systemic contact dermatitis after oral exposure to nickel: a review with a modified meta-analysis","volume":"54","author":"Jensen CS","year":"2006","unstructured":"Jensen CS, , Menn\u00e9 T, , Johansen JD. Systemic contact dermatitis after oral exposure to nickel: a review with a modified meta-analysis. Contact Dermatitis, 2006; 54 (2): 79\u201386.","journal-title":"Contact Dermatitis"},{"issue":"1","key":"e_1_3_1_8_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1600-0536.1984.tb00168.x","article-title":"Delayed type allergy to spices","volume":"11","author":"Niinim\u00e4ki A","year":"1984","unstructured":"Niinim\u00e4ki A. Delayed type allergy to spices. Contact Dermatitis, 1984; 11 (1): 34\u201340.","journal-title":"Contact Dermatitis"},{"issue":"2","key":"e_1_3_1_9_2","first-page":"128","article-title":"Pharmaceutical excipients: adverse effects associated with inactive ingredients in drug products (Part I)","volume":"3","author":"Golightly LK","year":"1988","unstructured":"Golightly LK, , Smolinske SS, , Bennett ML, et al. Pharmaceutical excipients: adverse effects associated with inactive ingredients in drug products (Part I). Med Toxicol Adverse Drug Exp, 1988; 3 (2): 128\u2013165.","journal-title":"Med Toxicol Adverse Drug Exp"},{"issue":"8","key":"e_1_3_1_10_2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1398-9995.1987.tb00386.x","article-title":"Hypersensitivity reactions to food additives","volume":"42","author":"Hannuksela M","year":"1987","unstructured":"Hannuksela M, , Haahtela T. Hypersensitivity reactions to food additives. Allergy, 1987; 42 (8): 561\u2013575.","journal-title":"Allergy"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02116.x"},{"issue":"4","key":"e_1_3_1_12_2","first-page":"247","article-title":"Sorbic acid: an unusual cause of systemic contact dermatitis in an infant","volume":"43","author":"Raison-Peyron N","year":"2000","unstructured":"Raison-Peyron N, , Meynadier JM, , Meynadier J. Sorbic acid: an unusual cause of systemic contact dermatitis in an infant. Contact Dermatitis, 2000; 43 (4): 247\u2013248.","journal-title":"Contact Dermatitis"},{"issue":"1","key":"e_1_3_1_13_2","first-page":"99","article-title":"Medication dyes as a source of drug allergy","volume":"12","author":"Swerlick RA","year":"2013","unstructured":"Swerlick RA, , Campbell CF. Medication dyes as a source of drug allergy. J Drugs Dermatol, 2013; 12 (1): 99\u2013102.","journal-title":"J Drugs Dermatol"},{"issue":"3","key":"e_1_3_1_14_2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1398-9995.2006.01287.x","article-title":"Severe skin reaction due to excipients of an oral iron treatment","volume":"62","author":"Rogkakou A","year":"2007","unstructured":"Rogkakou A, , Guerra L, , Scordamaglia A, et al. Severe skin reaction due to excipients of an oral iron treatment. Allergy, 2007; 62 (3): 334\u2013335.","journal-title":"Allergy"},{"issue":"6","key":"e_1_3_1_15_2","first-page":"327","article-title":"Systemic contact dermatitis due to intravenous Valium in a person sensitive to propylene glycol","volume":"55","author":"Fisher AA","year":"1995","unstructured":"Fisher AA. Systemic contact dermatitis due to intravenous Valium in a person sensitive to propylene glycol. Cutis, 1995; 55 (6): 327\u2013328.","journal-title":"Cutis"},{"issue":"1","key":"e_1_3_1_16_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-0536.1978.tb03719.x","article-title":"Reactions to peroral propylene glycol","volume":"4","author":"Hannuksela M","year":"1978","unstructured":"Hannuksela M, , F\u00f6rstr\u00f6m L. Reactions to peroral propylene glycol. 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Letter: systemic eczematous \u201ccontact-type\u201d dermatitis medicamentosa caused by parabens. Arch Dermatol, 1974; 110 (4): 640.","journal-title":"Arch Dermatol"},{"issue":"4","key":"e_1_3_1_19_2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1600-0536.1990.tb01580.x","article-title":"Systemic contact dermatitis due to parabens","volume":"22","author":"Carradori S","year":"1990","unstructured":"Carradori S, , Peluso AM, , Faccioli M. Systemic contact dermatitis due to parabens. Contact Dermatitis, 1990; 22 (4): 238\u2013239.","journal-title":"Contact Dermatitis"},{"issue":"5","key":"e_1_3_1_20_2","first-page":"469","article-title":"Delayed hypersensitivity reaction to orally administered methylparaben","volume":"1","author":"Kaminer Y","year":"1982","unstructured":"Kaminer Y, , Apter A, , Tyano S, et al. Delayed hypersensitivity reaction to orally administered methylparaben. Clin Pharm, 1982; 1 (5): 469\u2013470.","journal-title":"Clin Pharm"},{"issue":"2","key":"e_1_3_1_21_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.0105-1873.2006.0560a.x","article-title":"Allergic and systemic contact dermatitis to methylparaben","volume":"54","author":"S\u00e1nchez-P\u00e9rez J","year":"2006","unstructured":"S\u00e1nchez-P\u00e9rez J, , Diez MB, , P\u00e9rez AA, et al. Allergic and systemic contact dermatitis to methylparaben. Contact Dermatitis, 2006; 54 (2): 117\u2013118.","journal-title":"Contact Dermatitis"},{"issue":"6","key":"e_1_3_1_22_2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1525-1470.2008.00855.x","article-title":"Systematized contact dermatitis and montelukast in an atopic boy","volume":"26","author":"Castanedo-Tardan MP","year":"2009","unstructured":"Castanedo-Tardan MP, , Gonz\u00e1lez ME, , Connelly EA, et al. Systematized contact dermatitis and montelukast in an atopic boy. Pediatr Dermatol, 2009; 26 (6): 739\u2013743.","journal-title":"Pediatr Dermatol"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2003.0225a.x"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01130.x"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02147.x"}],"container-title":["Dermatitis\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1097\/DER.0000000000000028","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1097\/DER.0000000000000028","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1097\/DER.0000000000000028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:08:21Z","timestamp":1777399701000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1097\/DER.0000000000000028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,1]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4,1]]}},"alternative-id":["10.1097\/DER.0000000000000028"],"URL":"https:\/\/doi.org\/10.1097\/der.0000000000000028","relation":{},"ISSN":["1710-3568","2162-5220"],"issn-type":[{"value":"1710-3568","type":"print"},{"value":"2162-5220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,1]]}}}