{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T17:44:06Z","timestamp":1785001446837,"version":"3.55.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Atopic dermatitis (AD) is a common chronic inflammatory skin disease.\n                      <jats:italic toggle=\"yes\">Malassezia<\/jats:italic>\n                      , the predominant skin microbiota fungus, is considered to exacerbate AD, especially in a subset of patients with head and neck type AD (HNAD). In the present study, the relationship between AD and sensitization to\n                      <jats:italic toggle=\"yes\">Malassezia<\/jats:italic>\n                      antigens was investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We assessed 173 patients with AD. The severity of eczema was determined with Eczema Area and Severity Index (EASI); the type of AD, namely, head and neck type, was reported as well. The total serum IgE and specific IgE to\n                      <jats:italic toggle=\"yes\">Malassezia<\/jats:italic>\n                      were determined and correlated with clinical picture of AD, sex, age, and the EASI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Total IgE was elevated in 77.7% of patients. Specific IgE to\n                      <jats:italic toggle=\"yes\">Malassezia<\/jats:italic>\n                      was positive (\u22650.35 kU\/L) in 49.1% of patients. Men were significantly more often sensitized to\n                      <jats:italic toggle=\"yes\">Malassezia<\/jats:italic>\n                      antigen (58% of men vs 42% of women;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value, 0.04). Concurrently, 58% of patients with HNAD versus 42% non-HNAD patients had higher levels of specific IgE to\n                      <jats:italic toggle=\"yes\">Malassezia<\/jats:italic>\n                      , this difference being nearly significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value, 0.06). Patients with atopy were also more frequently sensitized to\n                      <jats:italic toggle=\"yes\">Malassezia<\/jats:italic>\n                      . No significant relationship between EASI and the level of total IgE or specific IgE to\n                      <jats:italic toggle=\"yes\">Malassezia<\/jats:italic>\n                      was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In our population, IgE-mediated sensitization was found in up to 49% of all patients with AD, most common in men and in head and neck type.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/der.0000000000000040","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T10:07:25Z","timestamp":1399889245000},"page":"120-126","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":70,"title":["IgE-Mediated Sensitization to\n                    <i>Malassezia<\/i>\n                    in Atopic Dermatitis: More Common in Male Patients and in Head and Neck Type"],"prefix":"10.1177","volume":"25","author":[{"given":"Petra","family":"Brodsk\u00e1","sequence":"first","affiliation":[{"name":"From the *Department of Dermatovenereology, University Hospital in Pilsen, Czech Republic;"},{"name":"Allergy Unit, Department of Dermatology, University Hospital of Zurich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Panzner","sequence":"additional","affiliation":[{"name":"Department of Immunology and Allergology, University Hospital in Pilsen, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Pizinger","sequence":"additional","affiliation":[{"name":"From the *Department of Dermatovenereology, University Hospital in Pilsen, Czech Republic;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schmid-Grendelmeier","sequence":"additional","affiliation":[{"name":"Allergy Unit, Department of Dermatology, University Hospital of Zurich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,6,1]]},"reference":[{"key":"e_1_3_1_2_2","first-page":"645670","article-title":"Anti-Malassezia-specific IgE antibodies production in Japanese patients with head and neck atopic dermatitis: relationship between the level of specific IgE antibody and the colonization frequency of cutaneous Malassezia species and clinical severity","volume":"2011","author":"Zhang E","year":"2011","unstructured":"Zhang E, , Tanaka T, , Tajima M, et al. 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