{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:04:59Z","timestamp":1777554299058,"version":"3.51.4"},"reference-count":59,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2019,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>An essential step in ensuring the toxicological safety of cosmetic or personal care products is the evaluation of the skin sensitizing potential of product ingredients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We used a standardized protocol from cosmetic trade industry and consumer safety groups to evaluate the sensitization potential of ingredients in 3 commercially available cleansing conditioners.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 33 ingredients were evaluated. Each ingredient underwent (1) dermatological evaluation, (2) in silico analysis for irritation and sensitization potential, and (3) a literature evaluation to determine risk of sensitization. Consumer exposure level was compared with the weight-of-evidence no-expected sensitization induction level for the constituent. If a no-expected sensitization induction level for a specific ingredient was not available, the dermal sensitization threshold approach was used. A margin of safety was calculated for each constituent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The margins of safety for all evaluated ingredients in the cleansing conditioners were greater than 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This analysis indicates that exposure to the individual ingredients present in these cleansing conditioners would not be expected to induce dermal sensitization in a consumer under the examined exposure scenario.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/der.0000000000000445","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T16:54:54Z","timestamp":1551804894000},"page":"116-128","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Skin Sensitization Induction Risk Assessment of Common Ingredients in Commercially Available Cleansing Conditioners"],"prefix":"10.1177","volume":"30","author":[{"given":"Andrew D.","family":"Monnot","sequence":"first","affiliation":[{"name":"From the, *Cardno ChemRisk, San Francisco, CA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin M.","family":"Towle","sequence":"additional","affiliation":[{"name":"From the, *Cardno ChemRisk, San Francisco, CA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin M.","family":"Warshaw","sequence":"additional","affiliation":[{"name":"Dermatology Department, University of Minnesota;"},{"name":"Park Nicollet, Minneapolis, MN;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest S.","family":"Fung","sequence":"additional","affiliation":[{"name":"Cardno ChemRisk, Aliso Viejo, CA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel M.","family":"Novick","sequence":"additional","affiliation":[{"name":"From the, *Cardno ChemRisk, San Francisco, CA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis J.","family":"Paustenbach","sequence":"additional","affiliation":[{"name":"Cardno ChemRisk, Jackson, WY;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek A.","family":"Drechsel","sequence":"additional","affiliation":[{"name":"Cardno ChemRisk, Boulder, CO."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,1]]},"reference":[{"key":"e_1_3_1_2_2","unstructured":"Sifferlin A. 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