{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:15:27Z","timestamp":1777554927973,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Potential fragrance allergens used in daily products should have a concentration limited to levels that are at, or below, acceptable exposure levels based on the quantitative risk assessment for the induction of dermal sensitization. To date, there are insufficient data to discern any quantitative relationship between induction and elicitation concentrations for fragrance ingredients that have a potential for dermal sensitization. When available, these data should be used to confirm the effectiveness of quantitative risk assessment\u2013based risk management procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this study, the relationship between the allergen concentration and the time to elicit allergic contact dermatitis in eugenol-sensitized patients was studied. The products used to elicit allergic contact dermatitis had a concentration of eugenol that was equal to, or below, the International Fragrance Association standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Volunteers with and without known sensitization to eugenol were patch tested with various concentrations of eugenol (dilution series) and also underwent repeated open application tests (ROATs). This study model has previously been successfully used with stronger sensitizers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this study, allergic contact dermatitis, as evidenced by a positive ROAT, could not be elicited by any of the concentrations studied, including in those patients where the patch tests were positive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>When tested in a 3-week ROAT at, or below, its current International Fragrance Association Standard, eugenol did not induce reactions even in those known to be sensitized. Whether this represents a false-negative result for a weak allergen is unknown.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/der.0b013e31823d17b8","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T12:05:37Z","timestamp":1397649937000},"page":"32-38","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Does the New Standard for Eugenol Designed to Protect against Contact Sensitization Protect Those Sensitized from Elicitation of the Reaction?"],"prefix":"10.1177","volume":"23","author":[{"given":"Cecilia","family":"Svedman","sequence":"first","affiliation":[{"name":"From the *Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malin","family":"Engfeldt","sequence":"additional","affiliation":[{"name":"From the *Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Marie","family":"Api","sequence":"additional","affiliation":[{"name":"Research Institute for Fragrance Materials, Inc, Woodcliff Lake, NJ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie T.","family":"Politano","sequence":"additional","affiliation":[{"name":"Research Institute for Fragrance Materials, Inc, Woodcliff Lake, NJ;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald V.","family":"Belsito","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Columbia University, New York, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta","family":"Gruvberger","sequence":"additional","affiliation":[{"name":"From the *Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"From the *Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,2,1]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00418.x"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304110-00006"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2007.10.008"},{"key":"e_1_3_1_5_2","first-page":"77","article-title":"Fragrance contact dermatitis: a worldwide multicenter investigation (Part I)","volume":"7","author":"Larsen W","year":"1996","unstructured":"Larsen W, , Nakayama H, , Lindberg M, et al. Fragrance contact dermatitis: a worldwide multicenter investigation (Part I). Am J Contact Dermat, 1996; 7: 77\u201383.","journal-title":"Am J Contact Dermat"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.044006344.x"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00565.x"},{"key":"e_1_3_1_8_2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1053\/ajcd.1998.2918","article-title":"A study of new fragrance mixtures","volume":"9","author":"Larsen W","year":"1998","unstructured":"Larsen W, , Nakayama H, , Fisher T, et al. A study of new fragrance mixtures. Am J Contact Dermatitis, 1998; 9: 202\u2013206.","journal-title":"Am J Contact Dermatitis"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2003.480201.x"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155501750208155"},{"key":"e_1_3_1_11_2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1600-0536.1995.tb02048.x","article-title":"Patch testing with fragrances results of a multicenter study of the European Environmental and Contact Dermatitis Research Group with 48 frequently used constituents of perfumes","volume":"33","author":"Frosch PJ","year":"1995","unstructured":"Frosch PJ, , Pilz B, , Andersen KE, et al. Patch testing with fragrances results of a multicenter study of the European Environmental and Contact Dermatitis Research Group with 48 frequently used constituents of perfumes. 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Textbook of Contact Dermatitis. 3rd ed. Berlin, Hendelberg, Germany: Springer Verlag; 2001.","edition":"3"},{"key":"e_1_3_1_15_2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1600-0536.1986.tb01229.x","article-title":"The repeated open application test (ROAT)","volume":"19","author":"Hannuksela M","year":"1986","unstructured":"Hannuksela M, , Salo H. The repeated open application test (ROAT). Contact Dermatitis, 1986; 19: 221\u2013222.","journal-title":"Contact Dermatitis"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00906.x"},{"key":"e_1_3_1_17_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.0105-1873.2005.00481.x","article-title":"Repeated open application test with methyldibromoglutaronitrile, a multicentre study within the EECDRG","volume":"52","author":"Gruvberger B","year":"2005","unstructured":"Gruvberger B, , Andersen KE, , Brandao FM, et al. 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Contact Dermatitis, 2003; 48: 217\u2013223.","journal-title":"Contact Dermatitis"},{"key":"e_1_3_1_21_2","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.fct.2004.05.009","article-title":"Correlation of patch test reactivity and the repeated open application test (ROAT)\/provocative use test (PUT)","volume":"42","author":"Villarama CD","year":"2004","unstructured":"Villarama CD, , Maibach HI. Correlation of patch test reactivity and the repeated open application test (ROAT)\/provocative use test (PUT). Food Chem Toxicol, 2004; 42: 1719\u20131725.","journal-title":"Food Chem Toxicol"},{"key":"e_1_3_1_22_2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1006\/taap.2000.9095","article-title":"The time-dose-response relationship for elicitation of contact dermatitis in isoeugenol allergic individuals","volume":"170","author":"Andersen KE","year":"2001","unstructured":"Andersen KE, , Johansen JD, , Bruze M, et al. 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